(98 nodes) Toll-like receptor signaling pathway network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108896630	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	LOC108896631	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (94 aa)
	LOC108902352	TIR domain-containing protein. (821 aa)
	LOC108891661	Uncharacterized protein. (473 aa)
	LOC108881026	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
	LOC108892325	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	IL12B-2	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (295 aa)
	ENSLCAP00010002551	SH2 domain-containing protein. (123 aa)
	ENSLCAP00010002564	SH2 domain-containing protein. (312 aa)
	LOC108899401	TNF_2 domain-containing protein. (254 aa)
	jun	BZIP domain-containing protein; Belongs to the bZIP family. (322 aa)
	LOC108882620	Mitogen-activated protein kinase. (363 aa)
	tab2	Uncharacterized protein. (761 aa)
	map3k8	Protein kinase domain-containing protein. (477 aa)
	ENSLCAP00010005490	Toll-like receptor 1; Belongs to the Toll-like receptor family. (811 aa)
	Ikbkb	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (746 aa)
	LOC108888278	SCY domain-containing protein. (140 aa)
	LOC108890197	SCY domain-containing protein. (91 aa)
	LOC108888287	Mitogen-activated protein kinase. (464 aa)
	LOC108895835	ANK_REP_REGION domain-containing protein. (307 aa)
	mapk10	Mitogen-activated protein kinase. (476 aa)
	LOC108883170	TIR domain-containing protein. (878 aa)
	ctsk	Uncharacterized protein; Belongs to the peptidase C1 family. (329 aa)
	LOC108899251	SCY domain-containing protein. (110 aa)
	ENSLCAP00010009882	Mitogen-activated protein kinase 9. (411 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1086 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1040 aa)
	LOC108877315	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (401 aa)
	LOC108895804	TIR domain-containing protein; Belongs to the Toll-like receptor family. (890 aa)
	TLR8	Toll like receptor 8. (1037 aa)
	ENSLCAP00010013353	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1047 aa)
	LOC108897837	Uncharacterized protein. (227 aa)
	ENSLCAP00010014491	Mitogen-activated protein kinase. (361 aa)
	il12b	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (353 aa)
	RAC1	Uncharacterized protein. (192 aa)
	pik3r1	Uncharacterized protein. (728 aa)
	LOC108882207	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ENSLCAP00010015481	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
	LOC108889978	TNFR-Cys domain-containing protein. (275 aa)
	tirap	TIR domain-containing protein. (267 aa)
	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (508 aa)
	ENSLCAP00010017630	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (327 aa)
	LOC108895610	BZIP domain-containing protein. (389 aa)
	LOC108895611	BZIP domain-containing protein. (381 aa)
	tollip	CUE domain-containing protein. (275 aa)
	LOC108896372	TNF_2 domain-containing protein. (242 aa)
	LOC108901953	SCY domain-containing protein. (99 aa)
	LOC108880505	Uncharacterized protein. (195 aa)
	LOC108901401	Mitogen-activated protein kinase. (368 aa)
	ENSLCAP00010019583	Uncharacterized protein; Belongs to the peptidase C1 family. (386 aa)
	ENSLCAP00010020135	Uncharacterized protein. (474 aa)
	ripk1	Uncharacterized protein. (684 aa)
	LOC108903099	SCY domain-containing protein. (116 aa)
	ENSLCAP00010021711	V-rel avian reticuloendotheliosis viral oncogene homolog A. (625 aa)
	ENSLCAP00010021874	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (292 aa)
	LOC108882672	Mitogen-activated protein kinase. (364 aa)
	irf5	IRF tryptophan pentad repeat domain-containing protein. (487 aa)
	LOC108888912	Uncharacterized protein. (486 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (419 aa)
	ikbke	Protein kinase domain-containing protein. (725 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
	LOC108891107	Protein kinase domain-containing protein. (770 aa)
	ENSLCAP00010030168	Uncharacterized protein. (718 aa)
	ENSLCAP00010031544	SH2 domain-containing protein. (443 aa)
	LOC108883553	Uncharacterized protein. (573 aa)
	map2k4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (434 aa)
	pik3r3	Uncharacterized protein. (740 aa)
	LOC108883596	Protein kinase domain-containing protein. (395 aa)
	irf7	IRF tryptophan pentad repeat domain-containing protein. (441 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (609 aa)
	ENSLCAP00010041012	Interleukin-1. (240 aa)
	ENSLCAP00010041368	Signal transducer and activator of transcription. (732 aa)
	LOC108875352	Mitogen-activated protein kinase. (362 aa)
	tlr3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (922 aa)
	LOC108892487	BZIP domain-containing protein. (381 aa)
	LOC108873245	Uncharacterized protein. (244 aa)
	tbk1	Uncharacterized protein. (723 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (319 aa)
	pik3r2	Uncharacterized protein. (736 aa)
	ENSLCAP00010046861	Uncharacterized protein. (363 aa)
	LOC108880106	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	nfkbia	ANK_REP_REGION domain-containing protein. (319 aa)
	ENSLCAP00010048298	Mitogen-activated protein kinase. (440 aa)
	LOC108885865	TIR domain-containing protein. (821 aa)
	ENSLCAP00010050445	NEMO domain-containing protein. (371 aa)
	LOC108878374	Interleukin-1. (278 aa)
	irak4	Protein kinase domain-containing protein. (458 aa)
	LOC108883763	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC108878496	SCY domain-containing protein. (118 aa)
	LOC108883804	Uncharacterized protein. (467 aa)
	ENSLCAP00010054907	TNFR-Cys domain-containing protein. (380 aa)
	LOC108876848	Protein kinase domain-containing protein. (359 aa)
	MAP2K6	Protein kinase domain-containing protein. (336 aa)
	LOC108890897	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (412 aa)
	LOC108884442	IRF tryptophan pentad repeat domain-containing protein. (466 aa)
	ENSLCAP00010059112	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (647 aa)
	LOC108882522	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLCAP00010002551	ENSLCAP00010002564	ENSLCAP00010002551	ENSLCAP00010002564	SH2 domain-containing protein.	SH2 domain-containing protein.	0.903
ENSLCAP00010002551	ENSLCAP00010041368	ENSLCAP00010002551	ENSLCAP00010041368	SH2 domain-containing protein.	Signal transducer and activator of transcription.	0.909
ENSLCAP00010002551	ikbke	ENSLCAP00010002551	ENSLCAP00010026935	SH2 domain-containing protein.	Protein kinase domain-containing protein.	0.936
ENSLCAP00010002564	ENSLCAP00010002551	ENSLCAP00010002564	ENSLCAP00010002551	SH2 domain-containing protein.	SH2 domain-containing protein.	0.903
ENSLCAP00010002564	ENSLCAP00010041368	ENSLCAP00010002564	ENSLCAP00010041368	SH2 domain-containing protein.	Signal transducer and activator of transcription.	0.903
ENSLCAP00010002564	ikbke	ENSLCAP00010002564	ENSLCAP00010026935	SH2 domain-containing protein.	Protein kinase domain-containing protein.	0.936
ENSLCAP00010005490	LOC108883170	ENSLCAP00010005490	ENSLCAP00010009400	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein.	0.942
ENSLCAP00010005490	LOC108883553	ENSLCAP00010005490	ENSLCAP00010033885	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Uncharacterized protein.	0.413
ENSLCAP00010005490	LOC108885865	ENSLCAP00010005490	ENSLCAP00010049945	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein.	0.974
ENSLCAP00010005490	LOC108888912	ENSLCAP00010005490	ENSLCAP00010025488	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Uncharacterized protein.	0.611
ENSLCAP00010005490	LOC108895804	ENSLCAP00010005490	ENSLCAP00010013256	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.430
ENSLCAP00010005490	LOC108902352	ENSLCAP00010005490	ENSLCAP00010000854	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein.	0.974
ENSLCAP00010005490	myd88	ENSLCAP00010005490	ENSLCAP00010022073	Toll-like receptor 1; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.617
ENSLCAP00010005490	tirap	ENSLCAP00010005490	ENSLCAP00010016297	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TIR domain-containing protein.	0.543
ENSLCAP00010005490	traf6	ENSLCAP00010005490	ENSLCAP00010039774	Toll-like receptor 1; Belongs to the Toll-like receptor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.502
ENSLCAP00010009882	ENSLCAP00010017630	ENSLCAP00010009882	ENSLCAP00010017630	Mitogen-activated protein kinase 9.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.994
ENSLCAP00010009882	ENSLCAP00010048298	ENSLCAP00010009882	ENSLCAP00010048298	Mitogen-activated protein kinase 9.	Mitogen-activated protein kinase.	0.911
ENSLCAP00010009882	LOC108876848	ENSLCAP00010009882	ENSLCAP00010055253	Mitogen-activated protein kinase 9.	Protein kinase domain-containing protein.	0.628
ENSLCAP00010009882	LOC108878374	ENSLCAP00010009882	ENSLCAP00010051161	Mitogen-activated protein kinase 9.	Interleukin-1.	0.547
ENSLCAP00010009882	LOC108881026	ENSLCAP00010009882	ENSLCAP00010001790	Mitogen-activated protein kinase 9.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.441