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mtlR mtlR marC_2 marC_2 FabR_1 FabR_1 yvoA yvoA CspG CspG rutR_2 rutR_2 yccA yccA sulA sulA adrA_2 adrA_2 ANJ96211.1 ANJ96211.1 ANJ91909.1 ANJ91909.1 ANJ91938.1 ANJ91938.1 yvdT yvdT qorA_1 qorA_1 ybhL ybhL ANJ92322.1 ANJ92322.1 yqjI yqjI seqA seqA fur fur ybeB ybeB adrA adrA yfiR yfiR CspE_1 CspE_1 ANJ92451.1 ANJ92451.1 ANJ92490.1 ANJ92490.1 acrR_1 acrR_1 nrdR_1 nrdR_1 ANJ92749.1 ANJ92749.1 ANJ92763.1 ANJ92763.1 rsmA rsmA sgrR_1 sgrR_1 trpR trpR yjjK_1 yjjK_1 ANJ92947.1 ANJ92947.1 ycdT_1 ycdT_1 badR badR rraB rraB treR treR nsrR nsrR ANJ93357.1 ANJ93357.1 ANJ93358.1 ANJ93358.1 rbsR_1 rbsR_1 phoU phoU slmA slmA rraA rraA metJ metJ fabR fabR gltC_2 gltC_2 ANJ93676.1 ANJ93676.1 yhgN_1 yhgN_1 lexA lexA ANJ93890.1 ANJ93890.1 qorA_2 qorA_2 yhdH yhdH gutB_4 gutB_4 ANJ94196.1 ANJ94196.1 CspJ CspJ betI betI ANJ96345.1 ANJ96345.1 ratA ratA rseA rseA LapB_2 LapB_2 hda hda yffB yffB napD napD yfbV yfbV IcaR IcaR ydaM_3 ydaM_3 ANJ95184.1 ANJ95184.1 glgS glgS paaX paaX CspC_2 CspC_2 cnu cnu flgM flgM fliT fliT CspC_1 CspC_1 marC_4 marC_4 ANJ95882.1 ANJ95882.1 NemR_2 NemR_2 nemR_1 nemR_1 purR_2 purR_2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mtlRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
marC_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
FabR_1TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
yvoAGntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
CspGCold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (70 aa)
rutR_2TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
yccAMembrane protein; Binds to the HflBKC complex which modulates FtsH activity; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the BI1 family. (219 aa)
sulACell division protein; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (168 aa)
adrA_2Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
ANJ96211.1Sensory transduction regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
ANJ91909.1Tail fiber assembly protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
ANJ91938.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
yvdTBetI family transcriptional regulator; Repressor involved in choline regulation of the bet genes. (198 aa)
qorA_1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
ybhLMembrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the BI1 family. (236 aa)
ANJ92322.13',5'-cyclic-nucleotide phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
yqjIPadR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
seqAReplication initiation regulator SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. (179 aa)
furFerric uptake regulator; Negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (148 aa)
ybeBRibosome-associated protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (105 aa)
adrADiguanylate cyclase; Catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
yfiRTetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
CspE_1Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (69 aa)
ANJ92451.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
ANJ92490.1Conjugal transfer protein TraB; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
acrR_1Transcriptional regulator; Regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
nrdR_1NrdR family transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa)
ANJ92749.1Repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
ANJ92763.1Tail assembly protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
rsmACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
sgrR_1Transcriptional regulator SgrR; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain. (553 aa)
trpRTrp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. (109 aa)
yjjK_1ABC transporter ATP-binding protein; ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)
ANJ92947.1NADPH:quinone reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (333 aa)
ycdT_1Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
badRHomoprotocatechuate degradative operon repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
rraBRegulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
treRRegulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
nsrRTranscriptional repressor NsrR; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa)
ANJ93357.1Cell division protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
ANJ93358.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
rbsR_1LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
phoUTranscriptional regulator PhoU; Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. (244 aa)
slmADivision inhibitor protein; FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
rraARibonuclease activity regulator protein RraA; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. (161 aa)
metJTranscriptional repressor protein MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa)
fabRTranscriptional regulator; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (210 aa)
gltC_2Transcriptional regulator HdfR; Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon. (275 aa)
ANJ93676.1TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
yhgN_1Antibiotic transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
lexALexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response). (202 aa)
ANJ93890.1Anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
qorA_2Quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
yhdHQuinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
gutB_4Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
ANJ94196.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
CspJCold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (70 aa)
betIBetI family transcriptional regulator; Repressor involved in choline regulation of the bet genes. (207 aa)
ANJ96345.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
ratACyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
rseAanti-RNA polymerase sigma factor SigE; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic protea [...] (217 aa)
LapB_2Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
hdaControls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DnaA family. (233 aa)
yffBReductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (121 aa)
napDNitrate reductase; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export. (87 aa)
yfbVHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
IcaRAcrR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
ydaM_3Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
ANJ95184.1NADPH:quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
glgSGlycogen synthesis protein; Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides. (71 aa)
paaXPhenylacetic acid degradation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
CspC_2Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (70 aa)
cnuoriC-binding nucleoid-associated protein; YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
flgMFlagellar biosynthesis anti-sigma factor FlgM; Regulates the flagellar specific sigma28 transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
fliTFlagellar biosynthesis protein FliT; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus. (122 aa)
CspC_1Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (69 aa)
marC_4Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
ANJ95882.1TetR-family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
NemR_2TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
nemR_1Transcriptional repressor NemR; Represses nemA which is involved in degradation of N-ethylmaleimide; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
purR_2Transcriptional regulator; Binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
Your Current Organism:
Serratia plymuthica
NCBI taxonomy Id: 82996
Other names: ATCC 183, Bacterium plymuthicum, CCUG 14509, CIP 103239, DSM 4540, LMG 7886, LMG:7886, NBRC 102599, NCTC 12961, S. plymuthica, Serratia sp. DBLH13
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