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yrbE2B yrbE2B pstS3 pstS3 pstS2 pstS2 pstS1 pstS1 sugC sugC lpqZ lpqZ oppA oppA Rv1457c Rv1457c Rv1686c Rv1686c yrbE3A yrbE3A yrbE3B yrbE3B Rv2038c Rv2038c Rv2060 Rv2060 Rv2326c Rv2326c cysA1 cysA1 ugpC ugpC drrB drrB drrC drrC Rv3041c Rv3041c yrbE4B yrbE4B yrbE4A yrbE4A dppA dppA proX proX yrbE1A yrbE1A yrbE1B yrbE1B yrbE2A yrbE2A
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
yrbE2BRv0588, (MTCY19H5.34c), len: 295 aa. YrbE2B,hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa), FASTA scores: opt: 232, E(): 8.4e-08, (22.1 % identity in 267 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical [...] (295 aa)
pstS3Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1); Functions in inorganic phosphate uptake, is probably the main carrier for phosphate uptake, it is the most highly expressed of the 3 PstS proteins under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Probably plays a role in host phagosome maturation arrest. (370 aa)
pstS2Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). (370 aa)
pstS1Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). (374 aa)
sugCProbable sugar-transport ATP-binding protein ABC transporter SugC; Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for energy coupling to the transport system. (393 aa)
lpqZProbable lipoprotein LpqZ; Rv1244, (MTV006.16), len: 286 aa. Probable lipoprotein lpqZ, equivalent toU15180|MLU1518042 protein u1756x from Mycobacterium leprae (228 aa), FASTA scores: opt: 1039, E(): 0, (72.5% identity in 229 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (286 aa)
oppARv1280c, (MTCY50.02), len: 591 aa. Probable oppA,oligopeptide-binding lipoprotein component of peptide transport system (see citation below), sharing some similarity to other periplasmic solute binding proteins e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding protein from Salmonella typhimurium (542 aa), FASTA scores: E(): 5.1e-05, (22.1% identity in 458 aa overlap); etc. Also similar to Rv1166 and Rv2585c from Mycobacterium tuberculosis. Has possible N-terminal signal sequence and prokaryotic lipoprotein lipid attachment site (PS00013). Belongs to the bacterial extracellular so [...] (591 aa)
Rv1457cRv1457c, (MTV007.04c), len: 261 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.32 from Mycobacterium leprae (265 aa), FASTA scores: opt: 1415, E(): 0, (83.1% identity in 260 aa overlap). (261 aa)
Rv1686cRv1686c, (MTCI125.08c), len: 226 aa. Probable conserved integral membrane protein ABC transporter (see citation below), similar to AL049819|SCE7.05 putative integral membrane protein from Streptomyces coelicolor (266 aa), FASTA sacores: opt: 661, E(): 0, (45.1% identity in 226 aa overlap); and Q53627|U43537 membrane protein involved in mithramycin resistance from streptomyces argillaceus (233 aa), FASTA scores: opt: 222, E(): 5.4e-10,(28.7% identity in 216 aa overlap). (226 aa)
yrbE3ARv1964, (MTV051.02), len: 265 aa. YrbE3A,hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa),O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa),Rv3501c|MTV023.08c|yrbE4A (254 aa), etc. Also highly similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. AAD24544.1|AF116213|YrbE1A from Mycobacterium leprae (112 aa); P45392|YRBE_ECOLI from Escherichia coli (260 aa), FASTA scores: opt: 893, E(): 0,(51.4% identity in 2 [...] (265 aa)
yrbE3BRv1965, (MTV051.03), len: 271 aa. YrbE4B,hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa), FASTA scores: opt: 937, E(): 0, (54.3% identity in 254 aa overlap); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. AAD24545.1|AF116213|YrbE1B from Mycobacterium leprae (106 aa); P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichi [...] (271 aa)
Rv2038cRv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), similar to many. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). (357 aa)
Rv2060Rv2060, (MTV019.01), len: 133 aa. Possible conserved integral membrane protein smaller than but similar to several hypothetical bacterial proteins e.g. >emb|CAC29843.1| (AL583918) putative ABC-transporter transmembrane protein [Mycobacterium leprae] Length = 286 and P44691|YEBI_HAEIN (261 aa). FASTA scores: P44691|YEBI_HAEIN hypothetical protein HI0407 (261 aa) opt: 218, E(): 4.2e-08; 31.1% identity in 122 aa overlap. Maybe frameshift upstream at position 3315980 but no error can be found to account for this. (133 aa)
Rv2326cRv2326c, (MTC3G12.08), len: 697 aa. Possible transmembrane ATP-binding protein ABC transporter (see citation below). Equivalent to Q9CCF9|ML0848 ABC transporter from Mycobacterium leprae (724 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap) and also to O32971|MLCB22.38c ABC-type transporter from Mycobacterium leprae (726 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap). Similar in part to other ABC transporters e.g. Q9WY65|TM0222 from Thermotoga maritima (266 aa), FASTA scores: opt: 407, E(): 4.2e-15, (38.0% identity in 213 [...] (697 aa)
cysA1Sulfate-transport ATP-binding protein ABC transporter CysA1; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (351 aa)
ugpCRv2832c, (MTCY16B7.10), len: 360 aa. Probable ugpC,Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter (see Braibant et al., 2000), similar to others: CAC48805 probable glycerol-3-phosphate ABC transporter ATP-binding protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (349 aa), FASTA scores: opt: 1018,E(): 4.1e-53, (48.6% identity in 356 aa overlap); Q98G42|MLL3499|UGPC SN-glycerol-3-phosphate transport ATP-binding protein from Rhizobium loti (Mesorhizobium loti) (366 aa), FASTA scores: opt: 1016, E(): 5.6e-53,(48.5% identity in 367 aa overlap). Bu [...] (360 aa)
drrBDaunorubicin-dim-transport integral membrane protein ABC transporter DrrB; Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. (289 aa)
drrCProbable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family. (276 aa)
Rv3041cRv3041c, (MTV012.56c), len: 287 aa. Probable conserved ATP-binding protein ABC transporter (see citation below), equivalent to Q9CBQ7|ML1726 putative ABC transporter protein ATP-binding protein from Mycobacterium leprae (305 aa), FASTA scores: opt: 1576, E(): 8.6e-85,(83.4% identity in 289 aa overlap). Also similar to other putative ATP-binding proteins ABC transporters e.g. Q9X9Z4|SCI5.06C from Streptomyces coelicolor (265 aa),FASTA scores: opt: 893, E(): 4.8e-45, (53.3% identity in 257 aa overlap); Q9L156|SC5C11.16c from Streptomyces coelicolor (279 aa), FASTA scores: opt: 680, E(): [...] (287 aa)
yrbE4BRv3500c, (MTV023.07c), len: 280 aa. YrbE4B,conserved integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa); O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa),FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity in 269 aa overlap); P45030|YRBE_ [...] (280 aa)
yrbE4ARv3501c, (MTV023.08c), len: 254 aa. YrbE4A,conserved integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g. Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa),FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity in 247 aa overlap); P45030|YRBE_ [...] (254 aa)
dppARv3666c, (MTV025.014c), len: 541 aa. Probable dppA,dipeptide-binding lipoprotein component of dipeptide transport system (see citation below), similar to many substrate-binding proteins e.g. Q9F353|SC9E12.02 putative peptide transport system secreted peptide-binding protein from Streptomyces coelicolor (544 aa), FASTA scores: opt: 1200, E(): 9e-67, (39.2% identity in 538 aa overlap); P24141|OPPA_BACSU oligopeptide-binding protein from Bacillus subtilis (545 aa), FASTA scores: opt: 523, E(): 7.9e-25, (26.15% identity in 516 aa overlap); P23843|OPPA_ECOLI periplasmic oligopeptide-binding [...] (541 aa)
proXRv3759c, (MTV025.107c), len: 315 aa. Possible proX,osmoprotectant-binding lipoprotein component of osmoprotectant transport system (see citation below),similar to osmoprotection proteins (proX) involved in glycine betaine/L-proline/choline transport, e.g. AAK79442|CAC1474 proline/glycine betaine ABC transport system periplasmic component from Clostridium acetobutylicum (303 aa), FASTA scores: opt: 308, E(): 1.2e-11, (27.4% identity in 314 aa overlap); Q9X4J2|PROXL|SCE19A.33 PROXL protein from Streptomyces coelicolor (322 aa), FASTA scores: opt: 302, E(): 3e-11,(27.2% identity in 327 aa [...] (315 aa)
yrbE1ARv0167, (MTCI28.07), len: 265 aa. YrbE1A, unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar or similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 328,E(): 1. [...] (265 aa)
yrbE1BRv0168, (MTCI28.08), len: 289 aa. YrbE1B, unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 223,E(): 7.6e-07, [...] (289 aa)
yrbE2ARv0587, (MTCY19H5.35c), len: 265 aa. YrbE2A,hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEA type, e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa), FASTA scores: opt: 287, E(): 6.1e-12, (21.5% identity in 256 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical p [...] (265 aa)
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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