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ugpB ugpB lpqY lpqY Rv2041c Rv2041c uspC uspC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ugpBRv2833c, (MTCY16B7.09), len: 436 aa. Probable ugpB,Sn-glycerol-3-phosphate binding lipoprotein component of Sn-glycerol-3-phosphate transport system (see citation below), similar to various transporters substrate-binding periplasmic proteins e.g. Q9KDY2|BH1079 glycerol-3-phosphate ABC transporter (glycerol-3-phosphate binding protein) from Bacillus halodurans (459 aa), FASTA scores: opt: 357, E(): 3.1e-14, (23.4% identity in 406 aa overlap); P72397|male putative maltose-binding protein from Streptomyces coelicolor (423 aa), FASTA scores: opt: 318,E(): 7e-12, (23.7% identity in 430 aa o [...] (436 aa)
lpqYProbable sugar-binding lipoprotein LpqY; Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence; Belongs to the bacterial solute-binding protein 1 family. (468 aa)
Rv2041cRv2041c, (MTV018.28c), len: 439 aa. Probable sugar-binding lipoprotein component of sugar transport system, similar to many. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (439 aa)
uspCRv2318, (MTCY3G12.16c), len: 440 aa. Probable uspC,sugar-binding lipoprotein component of sugar transport system (see citation below), most similar to Q9CBN6|USPC|ML1770 sugar transport periplasmic binding protein from Mycobacterium leprae (446 aa), FASTA scores: opt: 2294, E(): 8.1e-135, (74.7% identity in 446 aa overlap). Also similar to other substrate-binding proteins e.g. Q9RK89|SCF1.15 putative substrate binding protein (extracellular) (binding-protein-dependent transport) (fragment) from Streptomyces coelicolor (221 aa), FASTA scores: opt: 377, E(): 3e-16, (32.25% identity in 21 [...] (440 aa)
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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