STRINGSTRING
phoT phoT mkl mkl Rv0194 Rv0194 Rv0073 Rv0073 modC modC Rv2038c Rv2038c Rv2326c Rv2326c cysA1 cysA1 ettA ettA glnQ glnQ proV proV dppD dppD ftsE ftsE drrA drrA ugpC ugpC bacA bacA Rv1747 Rv1747 Rv1687c Rv1687c Rv1668c Rv1668c uvrA uvrA cydD cydD cydC cydC Rv1473 Rv1473 Rv1458c Rv1458c irtB irtB irtA irtA oppD oppD Rv1273c Rv1273c Rv1272c Rv1272c sugC sugC Rv1218c Rv1218c Rv0986 Rv0986 pstB pstB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
phoTProbable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. (258 aa)
mklPossible ribonucleotide-transport ATP-binding protein ABC transporter Mkl; Not known, could be involved in the transport of ribonucleotides. (359 aa)
Rv0194Probable transmembrane multidrug efflux pump; Overexpression in M. smegmatis increases resistance to erythromycin, ampicillin, novobiocin and vancomycin. It also reduces accumulation of ethidium bromide in the cell. Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. (1194 aa)
Rv0073Probable glutamine-transport ATP-binding protein ABC transporter; Probably part of an ABC transporter complex. Probably responsible for energy coupling to the transport system (By similarity). (330 aa)
modCProbable molybdenum-transport ATP-binding protein ABC transporter ModC; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (369 aa)
Rv2038cRv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), similar to many. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). (357 aa)
Rv2326cRv2326c, (MTC3G12.08), len: 697 aa. Possible transmembrane ATP-binding protein ABC transporter (see citation below). Equivalent to Q9CCF9|ML0848 ABC transporter from Mycobacterium leprae (724 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap) and also to O32971|MLCB22.38c ABC-type transporter from Mycobacterium leprae (726 aa), FASTA scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697 aa overlap). Similar in part to other ABC transporters e.g. Q9WY65|TM0222 from Thermotoga maritima (266 aa), FASTA scores: opt: 407, E(): 4.2e-15, (38.0% identity in 213 [...] (697 aa)
cysA1Sulfate-transport ATP-binding protein ABC transporter CysA1; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (351 aa)
ettAProbable macrolide-transport ATP-binding protein ABC transporter; A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase. (558 aa)
glnQRv2564, (MTCY9C4.04c), len: 330 aa. Probable glnQ,glutamine-transport ATP-binding protein ABC transporter (see citation below), highly similar to many e.g. Q9L0J9|SCD40A.12c putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (246 aa), FASTA scores: opt: 598, E(): 2.5e-26, (46.35% identity in 218 aa overlap); O54136|SC2E9.11 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 592, E(): 5.1e-26, (46.55% identity in 219 aa overlap); O29244|AF1018 from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 580, E(): 2.4e-25,(42.4% identity in 210 aa overlap); P758 [...] (330 aa)
proVRv3758c, (MTV025.106c), len: 376 aa. Possible proV,osmoprotectant transport ATP-binding protein ABC transporter (see citation below), highly similar to osmoprotection proteins (proV) involved in glycine betaine/L-proline/choline transport, e.g. BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 glycine betaine/carnitine/choline ABC transporter (ATP-binding) from Staphylococcus aureus (410 aa), FASTA scores: opt: 816, E(): 8.4e-39, (39.5% identity in 362 aa overlap); O34992|OPCA_BACSU|OPUCA glycine betaine/carnitine/choline transport ATP-binding protein from Bacillus subtilis (380 aa), FASTA scores: [...] (376 aa)
dppDRv3663c, (MTV025.011c), len: 548 aa. Probable dppD,dipeptide-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. AAK65441|SMA1434 probable ABC transporter ATP-binding protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (550 aa), FASTA scores: opt: 1528, E(): 1e-78, (46.25% identity in 545 aa overlap); O50270|MOAD MOAD protein from Agrobacterium radiobacter (588 aa), FASTA scores: opt: 1354, E(): 6.7e-69, (42.9% identity in 541 aa overlap); Q9KM01|VCA0588 putative peptide ABC transporter ATP-binding protein fro [...] (548 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. Has ATPase activity. (229 aa)
drrADaunorubicin-dim-transport ATP-binding protein ABC transporter DrrA; Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP; Belongs to the ABC transporter superfamily. Drug exporter-1 (DrugE1) (TC 3.A.1.105) family. (331 aa)
ugpCRv2832c, (MTCY16B7.10), len: 360 aa. Probable ugpC,Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter (see Braibant et al., 2000), similar to others: CAC48805 probable glycerol-3-phosphate ABC transporter ATP-binding protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (349 aa), FASTA scores: opt: 1018,E(): 4.1e-53, (48.6% identity in 356 aa overlap); Q98G42|MLL3499|UGPC SN-glycerol-3-phosphate transport ATP-binding protein from Rhizobium loti (Mesorhizobium loti) (366 aa), FASTA scores: opt: 1016, E(): 5.6e-53,(48.5% identity in 367 aa overlap). Bu [...] (360 aa)
bacAProbable drug-transport transmembrane ATP-binding protein ABC transporter BacA; ABC transporter involved in uptake of vitamin B12 and related corrinoids. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Contributes to maintenance of chronic infections. (639 aa)
Rv1747Probable conserved transmembrane ATP-binding protein ABC transporter; Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence; In the C-terminal section; belongs to the ABC-2 integral membrane protein family. (865 aa)
Rv1687cRv1687c, (MTCI125.09c), len: 255 aa. Probable conserved ATP-binding protein ABC transporter (see citation below), similar to many ABC-type transporters e.g. P55476|NODI_RHISN nodulation ATP-binding protein I from Rhizobium sp. (343 aa), FASTA scores: opt: 479, E(): 3.7e-23, (34.6% identity in 243 aa overlap); etc. Also similar to many other Mycobacterium tuberculosis ABC-type transporters e.g. MTCY19H9.04 (34.5% identity in 238 aa overlap). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein [...] (255 aa)
Rv1668cRv1668c, (MTV047.04c), len: 372 aa. Probable first part of macrolide-transport ATP-binding protein ABC transporter (see citation below), similar to many ATP-binding proteins ABC transporter e.g. X80735|SEABCT_1|Q54072 Saccharopolyspora erythraea ertX gene (481 aa), FASTA scores: opt: 938, E(): 0, (45.6% identity in 353 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no error found, also same sequence in Mycobacterium tuberculosis CSU93 and Mycobacterium bovis. Contain [...] (372 aa)
uvrAProbable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange. Belongs to the ABC transporter superfamily. UvrA family. (972 aa)
cydDRv1621c, (MTCY01B2.13c), len: 527 aa. Probable cydD,transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. P94366|CYDC_BACSU transport ATP-binding protein from Bacillus subtilis (567 aa), FASTA scores: opt: 784, E(): 0,(30.1% identity in 535 aa overlap); N-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa),FASTA scores: opt: 1295, E(): 0, (44.6% identity in 534 aa overlap); etc. Also similar to Q11019|Y07D_MYCTU from Mycobacterium tuberculosis (579 aa [...] (527 aa)
cydCRv1620c, (MTCY01B2.12c), len: 576 aa. Probable cydC,transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. CYDC_ECOLI|P23886 transport ATP-binding protein from Escherichia coli (573 aa), FASTA scores: opt: 631, E(): 1.6e-30, (28.5% identity in 569 aa overlap); C-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa), FASTA scores: opt: 956, E(): 0, (38.8% identity in 554 aa overlap); etc. Contains (PS00211) ABC transporters family signature, and (PS00017) [...] (576 aa)
Rv1473Rv1473, (MTV007.20), len: 542 aa. Possible macrolide-transport ATP-binding protein ABC transporter (see citation below), possibly in EF-3 subfamily. Similar to many ABC-transporters e.g. D90909_48|YHES_HAEIN from Synechocystis sp. strain PCC6803 (574 aa), FASTA scores: opt: 870, E(): 0, (33.3% identity in 525 aa overlap); P44808|YHES_HAEIN from Haemophilus influenzae (638 aa),FASTA scores: opt: 706, E(): 0, (33.7% identity in 517 aa overlap); etc. Contains two PS00017 ATP/GTP-binding site motif A (P-loop), and two PS00211 ABC transporter family signatures. Belongs to the ATP-binding tr [...] (542 aa)
Rv1458cRv1458c, (MTV007.05c), len: 313 aa. Possible unidentified antibiotic-transport ATP-binding protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.31 from Mycobacterium leprae (315 aa), FASTA scores: opt: 1812, E(): 0, (88.0% identity in 308 aa overlap). Similar to AF027770|AF027770_7 ABC-type transporter in FxbA region in Mycobacterium smegmatis (284 aa), FASTA scores: opt: 1412, E(): 0, (85.1% identity in 248 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protei [...] (313 aa)
irtBIron-regulated transporter IrtB; Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for replication in human macrophages and in mouse lungs. Belongs to the ABC transporter superfamily. Siderophore- Fe(3+) uptake transporter (SIUT) (TC 3.A.1.21) family. (579 aa)
irtAIron-regulated transporter IrtA; Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for replication in human macrophages and in mouse lungs. (859 aa)
oppDRv1281c, (MTCY50.01), len: 612 aa. Probable oppD,oligopeptide-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. DPPD_BACSU|P26905 dipeptide transport ATP-binding protein from Bacillus subtilis (335 aa), FASTA scores: opt: 983,E(): 0, (48.6% identity in 319 aa overlap); etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); 2 x PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters). (612 aa)
Rv1273cRv1273c, (MTCY50.09), len: 582 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), similar to e.g. YWJA_BACSU|P45861 hypothetical abc transporter from B. subtilis (575 aa), FASTA scores: opt: 810, E(): 0, (27.0% identity in 578 aa overlap); etc. Contains PS00136 Serine proteases, subtilase family, aspartic acid active site; 2 x PS00211 ABC transporters family signature; and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters),MSBA subfamily. (582 aa)
Rv1272cProbable drugs-transport transmembrane ATP-binding protein ABC transporter; ABC transporter involved in fatty acid import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable). (631 aa)
sugCProbable sugar-transport ATP-binding protein ABC transporter SugC; Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for energy coupling to the transport system. (393 aa)
Rv1218cProbable tetronasin-transport ATP-binding protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs. Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones. Probably responsible for energy coupling to the transport system (Probable). (311 aa)
Rv0986Rv0986, (MTV044.14), len: 248 aa. Probable ATP-binding protein ABC transporter supposedly involved in transport of adhesion component (see citation below),highly similar to many ATP-binding proteins e.g. AE0010|AE001033_8 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 669,E(): 0, (45.7% identity in 219 aa overlap); CAB81857.1|AL161691 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (246 aa); X84019|ZMDNAGRP_4 glutamate uptake regulatory protein (grp) from Z.mobilis (232 aa), FASTA score: (44.4% identity in 225 aa o [...] (248 aa)
pstBPhosphate-transport ATP-binding protein ABC transporter PstB; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. (276 aa)
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.