node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1314c | cobB | Rv1314c | Rv2848c | Conserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap); Belongs to the [...] | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.915 |
Rv1314c | cobD | Rv1314c | Rv2236c | Conserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap); Belongs to the [...] | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.915 |
Rv1314c | cobI | Rv1314c | Rv2066 | Conserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap); Belongs to the [...] | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.505 |
Rv1314c | cobL | Rv1314c | Rv2072c | Conserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap); Belongs to the [...] | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.575 |
Rv1314c | cobQ1 | Rv1314c | Rv0255c | Conserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap); Belongs to the [...] | Probable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.918 |
Rv1314c | cobS | Rv1314c | Rv2208 | Conserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap); Belongs to the [...] | Probable cobalamin 5'-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate (By similarity); Belongs to the CobS family. | 0.920 |
cobB | Rv1314c | Rv2848c | Rv1314c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Conserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap); Belongs to the [...] | 0.915 |
cobB | cobD | Rv2848c | Rv2236c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.899 |
cobB | cobH | Rv2848c | Rv2065 | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.997 |
cobB | cobI | Rv2848c | Rv2066 | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.959 |
cobB | cobK | Rv2848c | Rv2070c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.898 |
cobB | cobL | Rv2848c | Rv2072c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.934 |
cobB | cobM | Rv2848c | Rv2071c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.940 |
cobB | cobQ1 | Rv2848c | Rv0255c | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Probable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.968 |
cobB | cobS | Rv2848c | Rv2208 | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Probable cobalamin 5'-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate (By similarity); Belongs to the CobS family. | 0.964 |
cobB | cobT | Rv2848c | Rv2207 | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.922 |
cobD | Rv1314c | Rv2236c | Rv1314c | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Conserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa), FASTA scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa), FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in 172 aa overlap); Belongs to the [...] | 0.915 |
cobD | cobB | Rv2236c | Rv2848c | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Probable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.899 |
cobD | cobH | Rv2236c | Rv2065 | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.900 |
cobD | cobI | Rv2236c | Rv2066 | Probable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.940 |