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vapB45 vapB45 vapC1 vapC1 vapB25 vapB25 vapC25 vapC25 Rv0298 Rv0298 Rv0299 Rv0299 vapC3 vapC3 vapC30 vapC30 vapC6 vapC6 tuf tuf vapB31 vapB31 vapC31 vapC31 mazF3 mazF3 mazE3 mazE3 vapC10 vapC10 vapC12 vapC12 higB higB higA higA vapC45 vapC45 higA2 higA2 higB2 higB2 mazF7 mazF7 vapC37 vapC37 mazE8 mazE8 mazF8 mazF8 vapC38 vapC38 vapB17 vapB17 Rv2653c Rv2653c vapB42 vapB42 vapC49 vapC49 vapB49 vapB49 higB3 higB3 higA3 higA3 relJ relJ relK relK vapC46 vapC46 vapC47 vapC47 vapC50 vapC50 vapB50 vapB50
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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vapB45Conserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC45. (239 aa)
vapC1Possible toxin VapC1; Toxic component of a type II toxin-antitoxin (TA) system. The cognate antitoxin is VapB1 (By similarity). Has ribonuclease activity. (133 aa)
vapB25Rv0277A, len: 85 aa. Possible vapB25, antitoxin,part of toxin-antitoxin (TA) operon with Rv0277c, see Arcus et al. 2005. Has in-frame stop codon so may not be expressed. Very similar to others in Mycobacterium tuberculosis e.g. Rv0748 (85 aa). Fasta score E(): 4e-24; 88.2% identity in 85 aa overlap. (85 aa)
vapC25Possible toxin VapC25. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB25.; Belongs to the PINc/VapC protein family. (142 aa)
Rv0298Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299. (75 aa)
Rv0299Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv0298/MT0312. (100 aa)
vapC3Possible toxin VapC3; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB3. (137 aa)
vapC30Possible toxin VapC30. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB30.; Belongs to the PINc/VapC protein family. (131 aa)
vapC6Possible toxin VapC6; Toxic component of a type II type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB6 (By similarity). Belongs to the PINc/VapC protein family. (127 aa)
tufProbable iron-regulated elongation factor TU Tuf (EF-TU); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa)
vapB31Possible antitoxin VapB31; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC31. (85 aa)
vapC31Possible toxin VapC31. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB31 (By similarity). (142 aa)
mazF3Toxin MazF3; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes. Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. It dramatically increases per [...] (103 aa)
mazE3Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. (106 aa)
vapC10Possible toxin VapC10; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB10 (By similarity). Belongs to the PINc/VapC protein family. (133 aa)
vapC12Possible toxin VapC12; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB12 (By similarity). Belongs to the PINc/VapC protein family. (129 aa)
higBPossible toxin HigB; Toxic component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Upon expression in M.smegmatis inhibits colony formation and cell growth. Ectopic expression in wild-type M.tuberculosis has no effect on cell growth; ectopic expression in a triple higB1-higA1-Rv1957 (delta TAC) disruption mutant causes growth arrest, killing a considerable proportion of the cells. Increased ectopic expression leads to decreased levels of IdeR- and Zur-regulated genes as well as cleavage within the mRNA region of tmRNA (transfer-mRNA), strongly suggesting it is an endo [...] (125 aa)
higAPossible antitoxin HigA; Antitoxin component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin HigB1. Neutralization of HigB1 toxin in E.coli or M.marinum also requires SecB-like chaperone Rv1957, making this the first toxin-antitoxin chaperone (TAC) system. Antitoxin aggregation and degradation are prevented by the chaperone. (149 aa)
vapC45Conserved protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB45. (138 aa)
higA2Transcriptional regulatory protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin would be HigB2. (101 aa)
higB2Conserved protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA2. Belongs to the mycobacterial HigB family. (201 aa)
mazF7Possible toxin MazF7; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE7. Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. (136 aa)
vapC37Possible toxin VapC37. Contains PIN domain; Probable toxic component of a type II toxin-antitoxin (TA) system. An RNase. Upon expression in M.smegmatis inhibits colony formation. The putative cognate antitoxin is VapB37. (144 aa)
mazE8Possible antitoxin MazE8; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is MazF8. (82 aa)
mazF8Possible toxin MazF8; Putative toxic component of a type II toxin-antitoxin (TA) system, its cognate toxin is MaZE8. Probably an endoribonuclease (By similarity). (105 aa)
vapC38Possible toxin VapC38. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB38 (By similarity). (141 aa)
vapB17Possible antitoxin VapB17; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC17. (75 aa)
Rv2653cPossible PhiRv2 prophage protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin Rv2654c. (107 aa)
vapB42Possible antitoxin VapB42; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC42. (89 aa)
vapC49Hypothetical alanine rich protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB49 (By similarity). (144 aa)
vapB49Conserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC49 (Potential). (150 aa)
higB3Conserved hypothetical protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA3. Not toxic upon expression in M.smegmatis. (114 aa)
higA3Possible transcriptional regulatory protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin would be HigB3. (109 aa)
relJAntitoxin RelJ; Antitoxin component of a type II toxin-antitoxin (TA) system. A probable antitoxin for the putative mRNA interferase RelK. Upon expression in E.coli but not in M.smegmatis this protein neutralizes E.coli YoeB. (91 aa)
relKToxin RelK; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with antitoxin RelJ (shown only for M.smegmatis). Overexpression also increases the number of rifampcin-tolerant persister cells. Belongs to the YoeB family. (85 aa)
vapC46Possible toxin VapC46. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB46.; Belongs to the PINc/VapC protein family. (130 aa)
vapC47Possible toxin VapC47. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits translation and colony formation. Its toxic effect on colony formation is neutralized by coexpression with cognate antitoxin VapB47; the effect on translation has not been tested but is probably neutralized also.; Belongs to the PINc/VapC protein family. (136 aa)
vapC50Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB50. (169 aa)
vapB50Possible excisionase; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC50. (130 aa)
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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