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ppsA ppsA mmpL2 mmpL2 Rv0907 Rv0907 Rv1178 Rv1178 hemZ hemZ rpsA rpsA pncA pncA dlaT dlaT mqo mqo mas mas panD panD Rv3626c Rv3626c glpK glpK
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ppsAPhenolpthiocerol synthesis type-I polyketide synthase PpsA; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. (1876 aa)
mmpL2Rv0507, (MTCY20G9.34), len: 968 aa. Probable mmpL2,conserved transmembrane transport protein (see citations below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. YV34_MYCLE from Mycobacterium leprae (959 aa), FASTA scores: opt: 3699, E(): 0, (58.3% identity in 940 aa overlap); and the Mycobacterium tuberculosis proteins MTV037_14, MTV040_4, MTCY98_8,MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, etc. Also similar to STMACTII_3|SC10A5_9 from Streptomyces coelicolor; and BSUB0|004_12 from Bacillus subtilis. C-terminal half similar to Q50086|U1740AB from Myc [...] (968 aa)
Rv0907Conserved protein; Rv0907, (MTCY21C12.01), len: 532 aa. Conserved protein, possibly involved in cell wall biosynthesis: similar to many beta-lactamases, penicillin-binding proteins and hypothetical proteins e.g. NP_298910.1|NC_002488 beta-lactamase from Xylella fastidiosa (455 aa); Q06317|PBP4_NOCLA penicillin-binding protein 4 (PBP-4) (381 aa), FASTA scores: opt: 299, E(): 8.8e-05, (28.7% identity in 401 aa overlap); etc. N-terminus highly similar to AAA63047.1|U15184 hypothetical protein from Mycobacterium leprae (58 aa). Related to other putative esterases and penicillin binding pro [...] (532 aa)
Rv1178Rv1178, (MTV005.14), len: 362 aa. Probable aminotransferase, weak similarity to many aspartate aminotransferases e.g. Q55679|D64000 SLL0006 aspartate aminotransferase from Synechocystis sp. (394 aa), FASTA scores: opt: 218, E(): 1.3e-25, (32.5% identity in 379 aa overlap). Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. Also similar to Mycobacterium tuberculosis aminotransferases Rv2294,Rv0075, etc. (362 aa)
hemZFerrochelatase HemZ (protoheme ferro-lyase) (heme synthetase); Involved in the biosynthesis of heme. Catalyzes the ferrous insertion into protoporphyrin IX to form protoheme. (344 aa)
rpsA30S ribosomal protein S1 RpsA; Binds mRNA, facilitating recognition of most mRNAs by the 30S ribosomal subunit during translation initiation (By similarity). Probably plays a role in trans-translation; binds tmRNA (the product of the ssrA gene). In trans-translation Ala- aminoacylated transfer-messenger RNA (tmRNA, product of the ssrA gene; the 2 termini fold to resemble tRNA(Ala) while it encodes a short internal open reading frame (the tag peptide)) acts like a tRNA, entering the A-site of the ribosome and displacing the stalled mRNA (which is subsequently degraded). The ribosome the [...] (481 aa)
pncAPyrazinamidase/nicotinamidase PncA (PZase); Catalyzes the deamidation of nicotinamide (NAM) into nicotinate. Likely functions in the cyclical salvage pathway for production of NAD from nicotinamide (By similarity). Belongs to the isochorismatase family. (186 aa)
dlaTDlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Appears to be essential for Mtb pathogenesis. (553 aa)
mqoRv2852c, (MT2918, MTCY24A1.05), len: 493 aa. Probable mqo, malate:quinone oxidoreductase, highly similar to others e.g. O69282|MQO_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (499 aa), FASTA scores: opt: 1701, E(): 1.2e-101, (50.7% identity in 495 aa overlap); Q9Z9Q7|BH3960 from Bacillus halodurans (500 aa),FASTA scores: opt: 1632, E(): 3.3e-97, (48.55% identity in 486 aa overlap); Q9HYF4|MQOA|PA3452 from Pseudomonas aeruginosa (523 aa), FASTA scores: opt: 1604, E(): 2.1e-95,(49.1% identity in 487 aa overlap) (N-terminus longer); P33940|MQO_ECOLI|B2210 from Escherichi [...] (493 aa)
masRv2940c, (MTCY24G1.09, MTCY19H9.08c), len: 2111 aa. Probable mas, mycocerosic acid synthase membrane associated, multifunctional enzyme (see citations below),almost identical to Q02251|MCAS_MYCBO|mas mycocerosic acid synthase from Mycobacterium bovis (2110 aa), FASTA scores: opt: 13226, E(): 0, (95.8% identity in 2115 aa overlap) (see Mathur & Kolattukudy 1992); and equivalent to Q9CD78|mas|ML0139 putative mycocerosic synthase from Mycobacterium leprae (2116 aa), FASTA scores: opt: 12142,E(): 0, (87.95% identity in 2119 aa overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209 probable myc [...] (2111 aa)
panDProbable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase); Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family. (139 aa)
Rv3626cRv3626c, (MTCY15C10.26), len: 350 aa. Conserved hypothetical protein, similar to Q9X8I7|SCE9.14c hypothetical protein from Streptomyces coelicolor (375 aa) FASTA scores: opt: 720, E(): 2.2e-38, (41.55% identity in 361 aa overlap); and shows some similarity to Q9HPS0|VNG1497C hypothetical protein (317 aa) FASTA scores: opt: 226, E(): 4.5e-07, (29.7% identity in 347 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142). (350 aa)
glpKProbable glycerol kinase GlpK (ATP:glycerol 3-phosphotransferase) (glycerokinase) (GK); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (517 aa)
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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