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eccE5 eccE5 mak mak esxG esxG esxH esxH eccB5 eccB5 eccC5 eccC5 eccD5 eccD5 PE25 PE25 recA recA ftsK ftsK cfp6 cfp6 espC espC espA espA eccCa1 eccCa1 eccCb1 eccCb1 esxB esxB esxA esxA espB espB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
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eccE5ESX conserved component EccE5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. (406 aa)
makMaltokinase Mak; Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate (By similarity). Is involved in a branched alpha- glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB; Belongs to the aminoglycoside phosphotransferase family. (455 aa)
esxGESAT-6 like protein EsxG (conserved protein TB9.8); EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol. (97 aa)
esxHLow molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4); EsxH, in complex with EsxG, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. Belongs to the WXG100 family. ESAT-6 subfamily. (96 aa)
eccB5ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. (506 aa)
eccC5ESX conserved component EccC5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. (1391 aa)
eccD5ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. (503 aa)
PE25PE family protein PE25; The PE25/PPE41 dimer induces both a strong humoral and cellular immune response. PE25 protein alone induces low response. The dimer induces necrosis, but not apoptosis, in mouse macrophage cells. It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses. (99 aa)
recARecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. (790 aa)
ftsKPossible cell division transmembrane protein FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). (883 aa)
cfp6Rv3004, (MT3084.1, MTV012.18), len: 112 aa. Cfp6,low molecular weight protein antigen 6 (CFP-6) (See Bhaskar et al., 2000). Weak homology with Q9RKZ5|SC6D7.02 putative membrane protein from Streptomyces coelicolor (156 aa),FASTA scores: opt: 109, E(): 0.78, (39.4% identity in 122 aa overlap). Caution: the initiator methionine may be further upstream making the sequence a precursor. Predicted to be an outer membrane protein (See Song et al., 2008). (112 aa)
espCESX-1 secretion-associated protein EspC; Required for ESX-1 function. Required for either stability or expression of EspA. (103 aa)
espAESX-1 secretion-associated protein A, EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP-10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. (392 aa)
eccCa1ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). (747 aa)
eccCb1ESX conserved component EccCb1. ESX-1 type VII secretion system protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). EccCb1 may link the cytosolic components of the system with the membrane components. (591 aa)
esxB10 kDa culture filtrate antigen EsxB (LHP) (CFP10); A secreted protein. Acts as a strong host (human) T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA. EsxA and EsxA-EsxB are cytotoxic to pneumocytes. EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose-depend [...] (100 aa)
esxA6 kDa early secretory antigenic target EsxA (ESAT-6); A secreted protein that plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. Acts as a strong host (human) T-cell antigen. Inhibits IL- 12 p40 (IL12B) and TNF-alpha expression by infected host (mouse) macrophages, reduces the nitric oxide response by about 75%. In mice previously exposed to the bacterium, elicits high level of IFN-gamma production by T-cells upon subsequent challenge by M.tuberculosis, in the first phase of a protecti [...] (95 aa)
espBSecreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. (460 aa)
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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