node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2028c | Rv2030c | Rv2028c | Rv2030c | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Conserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008). | 0.986 |
Rv2028c | acg | Rv2028c | Rv2032 | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al., 2008); Belongs to the nitroreductase family. | 0.934 |
Rv2028c | devR | Rv2028c | Rv3133c | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family); Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormancy response. Regulates an approximately 48-member regulon. When phosphorylated binds and activates the promoter of DevR regulon genes in response to hypoxia. The presence of target DNA increases stability of phospho-DevR in vitro. Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters. Accepts [...] | 0.910 |
Rv2028c | hspX | Rv2028c | Rv2031c | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3); Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection. Belongs to the small heat shock protein (HSP20) family. | 0.917 |
Rv2028c | pfkB | Rv2028c | Rv2029c | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.993 |
Rv2030c | Rv2028c | Rv2030c | Rv2028c | Conserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008). | Rv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain. | 0.986 |
Rv2030c | acg | Rv2030c | Rv2032 | Conserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008). | Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al., 2008); Belongs to the nitroreductase family. | 0.963 |
Rv2030c | devR | Rv2030c | Rv3133c | Conserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008). | Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family); Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormancy response. Regulates an approximately 48-member regulon. When phosphorylated binds and activates the promoter of DevR regulon genes in response to hypoxia. The presence of target DNA increases stability of phospho-DevR in vitro. Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters. Accepts [...] | 0.748 |
Rv2030c | hspX | Rv2030c | Rv2031c | Conserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008). | Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3); Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection. Belongs to the small heat shock protein (HSP20) family. | 0.980 |
Rv2030c | pfkB | Rv2030c | Rv2029c | Conserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008). | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.996 |
Rv2034 | devR | Rv2034 | Rv3133c | ArsR repressor protein; Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions. | Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family); Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormancy response. Regulates an approximately 48-member regulon. When phosphorylated binds and activates the promoter of DevR regulon genes in response to hypoxia. The presence of target DNA increases stability of phospho-DevR in vitro. Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters. Accepts [...] | 0.460 |
Rv2037c | Rv2038c | Rv2037c | Rv2038c | Rv2037c, (MTV018.24c), len: 324 aa. Conserved transmembrane protein, similar to many. Alternative nucleotide at position 2282787 (C->T; C312Y) has been observed. Contains IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase motif. | Rv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), similar to many. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). | 0.807 |
Rv2037c | Rv2040c | Rv2037c | Rv2040c | Rv2037c, (MTV018.24c), len: 324 aa. Conserved transmembrane protein, similar to many. Alternative nucleotide at position 2282787 (C->T; C312Y) has been observed. Contains IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase motif. | Rv2040c, (MTV018.27c), len: 300 aa. Probable sugar-transport integral membrane protein ABC transporter (see citation below), similar to many. | 0.785 |
Rv2037c | Rv2041c | Rv2037c | Rv2041c | Rv2037c, (MTV018.24c), len: 324 aa. Conserved transmembrane protein, similar to many. Alternative nucleotide at position 2282787 (C->T; C312Y) has been observed. Contains IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase motif. | Rv2041c, (MTV018.28c), len: 439 aa. Probable sugar-binding lipoprotein component of sugar transport system, similar to many. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.827 |
Rv2037c | lipT | Rv2037c | Rv2045c | Rv2037c, (MTV018.24c), len: 324 aa. Conserved transmembrane protein, similar to many. Alternative nucleotide at position 2282787 (C->T; C312Y) has been observed. Contains IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase motif. | Rv2045c, (MTV018.32c), len: 511 aa. LipT,carboxylesterase, similar to many. Contains PS00941 Carboxylesterases type-B signature 2. Contains PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B carboxylesterase/lipase family. | 0.414 |
Rv2037c | pncA | Rv2037c | Rv2043c | Rv2037c, (MTV018.24c), len: 324 aa. Conserved transmembrane protein, similar to many. Alternative nucleotide at position 2282787 (C->T; C312Y) has been observed. Contains IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase motif. | Pyrazinamidase/nicotinamidase PncA (PZase); Catalyzes the deamidation of nicotinamide (NAM) into nicotinate. Likely functions in the cyclical salvage pathway for production of NAD from nicotinamide (By similarity). Belongs to the isochorismatase family. | 0.674 |
Rv2038c | Rv2037c | Rv2038c | Rv2037c | Rv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), similar to many. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). | Rv2037c, (MTV018.24c), len: 324 aa. Conserved transmembrane protein, similar to many. Alternative nucleotide at position 2282787 (C->T; C312Y) has been observed. Contains IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase motif. | 0.807 |
Rv2038c | Rv2040c | Rv2038c | Rv2040c | Rv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), similar to many. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). | Rv2040c, (MTV018.27c), len: 300 aa. Probable sugar-transport integral membrane protein ABC transporter (see citation below), similar to many. | 0.999 |
Rv2038c | Rv2041c | Rv2038c | Rv2041c | Rv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), similar to many. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). | Rv2041c, (MTV018.28c), len: 439 aa. Probable sugar-binding lipoprotein component of sugar transport system, similar to many. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.998 |
Rv2038c | lipT | Rv2038c | Rv2045c | Rv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), similar to many. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). | Rv2045c, (MTV018.32c), len: 511 aa. LipT,carboxylesterase, similar to many. Contains PS00941 Carboxylesterases type-B signature 2. Contains PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B carboxylesterase/lipase family. | 0.407 |