36 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8EPM6	ANK_REP_REGION domain-containing protein. (400 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	recql5	Uncharacterized protein. (1090 aa)
	bard1	Uncharacterized protein. (839 aa)
	rmi2	Uncharacterized protein. (152 aa)
	palb2	PALB2_WD40 domain-containing protein. (1427 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa)
	xrcc3	RECA_2 domain-containing protein. (360 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	Xrcc2.S	RECA_2 domain-containing protein. (223 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	Nbn.L	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
	Rad52.S	Uncharacterized protein. (429 aa)
	blm	Uncharacterized protein. (1368 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	A0A1L8H1D5	Uncharacterized protein. (1367 aa)
	A0A1L8H4R2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
	rpa2	RPA_C domain-containing protein. (274 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	rpa2-2	RPA_C domain-containing protein. (276 aa)
	A0A1L8HFV8	Helicase ATP-binding domain-containing protein. (92 aa)
	brip1	Helicase ATP-binding domain-containing protein. (1231 aa)
	A0A1L8HG81	RECA_2 domain-containing protein. (375 aa)
	Tdrd3.L	Uncharacterized protein. (775 aa)
	brca2	Tower domain-containing protein. (3177 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (711 aa)
	A0A1L8HPD7	Uncharacterized protein. (341 aa)
	A0A1L8HYF4	DUF1767 domain-containing protein. (512 aa)
	Top3b.L	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (824 aa)
	slf1	ANK_REP_REGION domain-containing protein. (904 aa)
	rpa3	LOC495401 protein. (121 aa)
	rpa3-2	Rpa3-prov protein. (121 aa)
	rad51d	MGC82048 protein. (324 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EPM6	A0A1L8H1D5	A0A1L8EPM6	A0A1L8H1D5	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.666
A0A1L8EPM6	A0A1L8H4R2	A0A1L8EPM6	A0A1L8H4R2	ANK_REP_REGION domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.716
A0A1L8EPM6	A0A1L8HFV8	A0A1L8EPM6	A0A1L8HFV8	ANK_REP_REGION domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.874
A0A1L8EPM6	A0A1L8HG81	A0A1L8EPM6	A0A1L8HG81	ANK_REP_REGION domain-containing protein.	RECA_2 domain-containing protein.	0.834
A0A1L8EPM6	A0A1L8HPD7	A0A1L8EPM6	A0A1L8HPD7	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.624
A0A1L8EPM6	A0A1L8HYF4	A0A1L8EPM6	A0A1L8HYF4	ANK_REP_REGION domain-containing protein.	DUF1767 domain-containing protein.	0.624
A0A1L8EPM6	Brca1.L	A0A1L8EPM6	A0A1L8ETS4	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.994
A0A1L8EPM6	Nbn.L	A0A1L8EPM6	A0A1L8FZE8	ANK_REP_REGION domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.981
A0A1L8EPM6	Rad52.S	A0A1L8EPM6	A0A1L8GQQ7	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.753
A0A1L8EPM6	Rbbp8.L	A0A1L8EPM6	A0A1L8FYP2	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.970
A0A1L8EPM6	Rpa1.L	A0A1L8EPM6	A0A1L8HDB4	ANK_REP_REGION domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.716
A0A1L8EPM6	Tdrd3.L	A0A1L8EPM6	A0A1L8HHG2	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.615
A0A1L8EPM6	Top3b.L	A0A1L8EPM6	A0A1L8I0K8	ANK_REP_REGION domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.655
A0A1L8EPM6	Xrcc2.S	A0A1L8EPM6	A0A1L8FQL1	ANK_REP_REGION domain-containing protein.	RECA_2 domain-containing protein.	0.676
A0A1L8EPM6	bard1	A0A1L8EPM6	A0A1L8EWU9	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.505
A0A1L8EPM6	blm	A0A1L8EPM6	A0A1L8GSC3	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.666
A0A1L8EPM6	brca2	A0A1L8EPM6	A0A1L8HIX3	ANK_REP_REGION domain-containing protein.	Tower domain-containing protein.	0.966
A0A1L8EPM6	brip1	A0A1L8EPM6	A0A1L8HG08	ANK_REP_REGION domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.874
A0A1L8EPM6	mre11	A0A1L8EPM6	A0A1L8HJD9	ANK_REP_REGION domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.990
A0A1L8EPM6	palb2	A0A1L8EPM6	A0A1L8EY82	ANK_REP_REGION domain-containing protein.	PALB2_WD40 domain-containing protein.	0.914