58 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mcm3	DNA helicase; Belongs to the MCM family. (807 aa)
	mcm6.2	DNA helicase; Belongs to the MCM family. (825 aa)
	Xcdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
	cdca7	zf-4CXXC_R1 domain-containing protein. (431 aa)
	Orc2.S	Uncharacterized protein. (558 aa)
	Dbf4b.L	DBF4-type domain-containing protein. (784 aa)
	Mcm6.2.L	DNA helicase; Belongs to the MCM family. (823 aa)
	orc4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (432 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	Mcmbp.L	Uncharacterized protein. (704 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	Cdc25a.S	Rhodanese domain-containing protein. (172 aa)
	mcm4	DNA helicase; Belongs to the MCM family. (858 aa)
	dbf4	Uncharacterized protein. (661 aa)
	mcm6	DNA helicase; Belongs to the MCM family. (821 aa)
	Mcm4.S	DNA helicase; Belongs to the MCM family. (863 aa)
	A0A1L8FZ43	MCM_lid domain-containing protein. (684 aa)
	Orc5.L	AAA_16 domain-containing protein. (440 aa)
	orc3	ORC_WH_C domain-containing protein. (709 aa)
	A0A1L8G614	MCM domain-containing protein; Belongs to the MCM family. (798 aa)
	mcm9	MCM domain-containing protein; Belongs to the MCM family. (1143 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	A0A1L8GBH4	Uncharacterized protein. (148 aa)
	zmcm3	DNA helicase; Belongs to the MCM family. (806 aa)
	Cdt1.S	CDT1 domain-containing protein. (615 aa)
	mcm5	DNA helicase; Belongs to the MCM family. (735 aa)
	atrip	Uncharacterized protein. (801 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (885 aa)
	gins2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
	Orc6.L	Uncharacterized protein. (252 aa)
	Orc1.L	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (886 aa)
	A0A1L8GMX9	Protein kinase domain-containing protein. (509 aa)
	mcm5-2	DNA helicase; Belongs to the MCM family. (735 aa)
	Rad26	Uncharacterized protein. (798 aa)
	Mcm2.L	DNA helicase; Belongs to the MCM family. (886 aa)
	Rhno1.S	Uncharacterized protein. (252 aa)
	Tipin.S	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
	Cdc25c1	Rhodanese domain-containing protein. (550 aa)
	A0A1L8GWA8	Uncharacterized protein. (209 aa)
	mcm10	Mcm10 domain-containing protein. (860 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa)
	Mrc1.L	C-type lectin domain-containing protein. (220 aa)
	A0A1L8H9R2	Uncharacterized protein. (1288 aa)
	Eln1.L	Uncharacterized protein. (904 aa)
	A0A1L8HF97	Uncharacterized protein. (489 aa)
	A0A1L8HHZ4	Uncharacterized protein. (1214 aa)
	Cdc45.S	Uncharacterized protein. (580 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	cdc45	Uncharacterized protein. (567 aa)
	rad9b	Cell cycle checkpoint control protein; Belongs to the rad9 family. (483 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	rad1	Uncharacterized protein. (283 aa)
	Clspn.S	Claspin. (1286 aa)
	gins1	MGC80254 protein. (196 aa)
	gins4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FZ43	A0A1L8GMX9	A0A1L8FZ43	A0A1L8GMX9	MCM_lid domain-containing protein.	Protein kinase domain-containing protein.	0.934
A0A1L8FZ43	A0A1L8H9R2	A0A1L8FZ43	A0A1L8H9R2	MCM_lid domain-containing protein.	Uncharacterized protein.	0.786
A0A1L8FZ43	A0A1L8HF97	A0A1L8FZ43	A0A1L8HF97	MCM_lid domain-containing protein.	Uncharacterized protein.	0.634
A0A1L8FZ43	A0A1L8HHZ4	A0A1L8FZ43	A0A1L8HHZ4	MCM_lid domain-containing protein.	Uncharacterized protein.	0.786
A0A1L8FZ43	Atr.L	A0A1L8FZ43	A0A1L8GAP7	MCM_lid domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.716
A0A1L8FZ43	Cdc45.S	A0A1L8FZ43	A0A1L8HQF8	MCM_lid domain-containing protein.	Uncharacterized protein.	0.939
A0A1L8FZ43	Cdt1.S	A0A1L8FZ43	A0A1L8GF06	MCM_lid domain-containing protein.	CDT1 domain-containing protein.	0.988
A0A1L8FZ43	Clspn.S	A0A1L8FZ43	F8WKR8	MCM_lid domain-containing protein.	Claspin.	0.634
A0A1L8FZ43	Dbf4b.L	A0A1L8FZ43	A0A1L8ESD2	MCM_lid domain-containing protein.	DBF4-type domain-containing protein.	0.791
A0A1L8FZ43	Eln1.L	A0A1L8FZ43	A0A1L8HDH2	MCM_lid domain-containing protein.	Uncharacterized protein.	0.791
A0A1L8FZ43	MCM7	A0A1L8FZ43	A0A1L8H3C0	MCM_lid domain-containing protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.992
A0A1L8FZ43	Mcm2.L	A0A1L8FZ43	A0A1L8GPN4	MCM_lid domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.940
A0A1L8FZ43	Mcm4.S	A0A1L8FZ43	A0A1L8FYX1	MCM_lid domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.968
A0A1L8FZ43	Mcmbp.L	A0A1L8FZ43	A0A1L8FIA9	MCM_lid domain-containing protein.	Uncharacterized protein.	0.847
A0A1L8FZ43	Orc1.L	A0A1L8FZ43	A0A1L8GMF1	MCM_lid domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.970
A0A1L8FZ43	Orc2.S	A0A1L8FZ43	A0A1L8EPN0	MCM_lid domain-containing protein.	Uncharacterized protein.	0.931
A0A1L8FZ43	Orc5.L	A0A1L8FZ43	A0A1L8FZ86	MCM_lid domain-containing protein.	AAA_16 domain-containing protein.	0.962
A0A1L8FZ43	Orc6.L	A0A1L8FZ43	A0A1L8GLD0	MCM_lid domain-containing protein.	Uncharacterized protein.	0.708
A0A1L8FZ43	Rad26	A0A1L8FZ43	A0A1L8GP12	MCM_lid domain-containing protein.	Uncharacterized protein.	0.417
A0A1L8FZ43	Tipin.S	A0A1L8FZ43	A0A1L8GSF3	MCM_lid domain-containing protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.765