28 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8EMT3	BTB domain-containing protein. (239 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	Sumo1.S	Ubiquitin-like domain-containing protein. (141 aa)
	ube2i	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	A0A1L8EUE2	BTB domain-containing protein. (245 aa)
	sumo2-2	Ubiquitin-like domain-containing protein. (98 aa)
	Sumo1.L	Ubiquitin-like domain-containing protein. (148 aa)
	A0A1L8EXX7	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	sae1	ThiF domain-containing protein. (344 aa)
	A0A1L8FRI6	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1695 aa)
	A0A1L8G0C9	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (1129 aa)
	Senp6.S	ULP_PROTEASE domain-containing protein. (1103 aa)
	senp5	ULP_PROTEASE domain-containing protein. (710 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (641 aa)
	pias1	Uncharacterized protein. (640 aa)
	Pias1.L	Uncharacterized protein. (649 aa)
	Ranbp2.S	Uncharacterized protein. (2843 aa)
	A0A1L8H9E8	Uncharacterized protein. (145 aa)
	Senp1.S	ULP_PROTEASE domain-containing protein. (546 aa)
	ranbp2	Uncharacterized protein. (2905 aa)
	Senp1.L	ULP_PROTEASE domain-containing protein. (616 aa)
	Pias2.S	Uncharacterized protein. (616 aa)
	Rnf4-a	RING-type domain-containing protein. (190 aa)
	Pias4.L	Uncharacterized protein. (544 aa)
	Pias2.L	Uncharacterized protein. (584 aa)
	A0A310U5D8	Rad60-SLD domain-containing protein. (67 aa)
	senp7	Sentrin/SUMO-specific protease 7. (901 aa)
	rnf4	LOC495944 protein. (190 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EMT3	A0A1L8FRI6	A0A1L8EMT3	A0A1L8FRI6	BTB domain-containing protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.676
A0A1L8EMT3	A0A1L8G0C9	A0A1L8EMT3	A0A1L8G0C9	BTB domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.623
A0A1L8EMT3	A0A1L8H9E8	A0A1L8EMT3	A0A1L8H9E8	BTB domain-containing protein.	Uncharacterized protein.	0.878
A0A1L8EMT3	A0A310U5D8	A0A1L8EMT3	A0A310U5D8	BTB domain-containing protein.	Rad60-SLD domain-containing protein.	0.905
A0A1L8EMT3	Pias1.L	A0A1L8EMT3	A0A1L8H180	BTB domain-containing protein.	Uncharacterized protein.	0.769
A0A1L8EMT3	Pias2.L	A0A1L8EMT3	A0A1L8I3K5	BTB domain-containing protein.	Uncharacterized protein.	0.769
A0A1L8EMT3	Pias2.S	A0A1L8EMT3	A0A1L8HS10	BTB domain-containing protein.	Uncharacterized protein.	0.769
A0A1L8EMT3	Pias4.L	A0A1L8EMT3	A0A1L8HW74	BTB domain-containing protein.	Uncharacterized protein.	0.769
A0A1L8EMT3	Ranbp2.S	A0A1L8EMT3	A0A1L8H8R8	BTB domain-containing protein.	Uncharacterized protein.	0.956
A0A1L8EMT3	Rnf4-a	A0A1L8EMT3	A0A1L8HT51	BTB domain-containing protein.	RING-type domain-containing protein.	0.470
A0A1L8EMT3	Senp1.L	A0A1L8EMT3	A0A1L8HIA0	BTB domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.431
A0A1L8EMT3	Senp1.S	A0A1L8EMT3	A0A1L8H9Y3	BTB domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.431
A0A1L8EMT3	Senp6.S	A0A1L8EMT3	A0A1L8G3E0	BTB domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.494
A0A1L8EMT3	Sumo1.L	A0A1L8EMT3	A0A1L8EWZ5	BTB domain-containing protein.	Ubiquitin-like domain-containing protein.	0.914
A0A1L8EMT3	Sumo1.S	A0A1L8EMT3	A0A1L8EPQ0	BTB domain-containing protein.	Ubiquitin-like domain-containing protein.	0.914
A0A1L8EMT3	pias1	A0A1L8EMT3	A0A1L8GSB5	BTB domain-containing protein.	Uncharacterized protein.	0.769
A0A1L8EMT3	ranbp2	A0A1L8EMT3	A0A1L8HGL2	BTB domain-containing protein.	Uncharacterized protein.	0.956
A0A1L8EMT3	rnf4	A0A1L8EMT3	Q5PQ91	BTB domain-containing protein.	LOC495944 protein.	0.470
A0A1L8EMT3	sae1	A0A1L8EMT3	A0A1L8F8T2	BTB domain-containing protein.	ThiF domain-containing protein.	0.978
A0A1L8EMT3	senp7	A0A1L8EMT3	B7TYL2	BTB domain-containing protein.	Sentrin/SUMO-specific protease 7.	0.494