(5 nodes) Mixed, incl. Sin3, C-terminal, and Catecholamine secretion network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tbl1xr1-2	Uncharacterized protein. (513 aa)
	Hdac3.S	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
	sin3a	HDAC_interact domain-containing protein. (1273 aa)
	Ncor1.L	Uncharacterized protein. (2518 aa)
	mecp2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (467 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hdac3.S	Ncor1.L	A0A1L8GVJ7	A0A1L8HD08	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Uncharacterized protein.	0.991
Hdac3.S	mecp2	A0A1L8GVJ7	Q9YGC6	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.726
Hdac3.S	sin3a	A0A1L8GVJ7	A0A1L8H013	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	HDAC_interact domain-containing protein.	0.921
Hdac3.S	tbl1xr1-2	A0A1L8GVJ7	A0A1L8GAH7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Uncharacterized protein.	0.951
Ncor1.L	Hdac3.S	A0A1L8HD08	A0A1L8GVJ7	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.991
Ncor1.L	mecp2	A0A1L8HD08	Q9YGC6	Uncharacterized protein.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.896
Ncor1.L	sin3a	A0A1L8HD08	A0A1L8H013	Uncharacterized protein.	HDAC_interact domain-containing protein.	0.968
Ncor1.L	tbl1xr1-2	A0A1L8HD08	A0A1L8GAH7	Uncharacterized protein.	Uncharacterized protein.	0.923
mecp2	Hdac3.S	Q9YGC6	A0A1L8GVJ7	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.726
mecp2	Ncor1.L	Q9YGC6	A0A1L8HD08	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	Uncharacterized protein.	0.896
mecp2	sin3a	Q9YGC6	A0A1L8H013	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	HDAC_interact domain-containing protein.	0.995
mecp2	tbl1xr1-2	Q9YGC6	A0A1L8GAH7	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	Uncharacterized protein.	0.751
sin3a	Hdac3.S	A0A1L8H013	A0A1L8GVJ7	HDAC_interact domain-containing protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.921
sin3a	Ncor1.L	A0A1L8H013	A0A1L8HD08	HDAC_interact domain-containing protein.	Uncharacterized protein.	0.968
sin3a	mecp2	A0A1L8H013	Q9YGC6	HDAC_interact domain-containing protein.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.995
sin3a	tbl1xr1-2	A0A1L8H013	A0A1L8GAH7	HDAC_interact domain-containing protein.	Uncharacterized protein.	0.565
tbl1xr1-2	Hdac3.S	A0A1L8GAH7	A0A1L8GVJ7	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.951
tbl1xr1-2	Ncor1.L	A0A1L8GAH7	A0A1L8HD08	Uncharacterized protein.	Uncharacterized protein.	0.923
tbl1xr1-2	mecp2	A0A1L8GAH7	Q9YGC6	Uncharacterized protein.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.751
tbl1xr1-2	sin3a	A0A1L8GAH7	A0A1L8H013	Uncharacterized protein.	HDAC_interact domain-containing protein.	0.565