(43 nodes) Mixed, incl. Reticulon, and Endoplasmic reticulum tubular network network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Vapb.L	MSP domain-containing protein. (289 aa)
	A0A1L8EZW3	Uncharacterized protein. (777 aa)
	Rtn1.S	Reticulon. (752 aa)
	atl1	GB1/RHD3-type G domain-containing protein. (558 aa)
	rtn2	Reticulon. (322 aa)
	rtn2-2	Reticulon. (321 aa)
	atl1-2	GB1/RHD3-type G domain-containing protein. (558 aa)
	A0A1L8FAD2	Uncharacterized protein. (1361 aa)
	Rtn1.L	Reticulon. (768 aa)
	pdzd8	Uncharacterized protein. (1074 aa)
	A0A1L8FEX2	FYVE-type domain-containing protein. (355 aa)
	A0A1L8FHW0	Uncharacterized protein. (480 aa)
	reep3	Receptor expression-enhancing protein. (263 aa)
	A0A1L8FJG2	FYVE-type domain-containing protein. (423 aa)
	vps13d	Uncharacterized protein. (4359 aa)
	Mag.L	Uncharacterized protein. (625 aa)
	Acbd5.L	Acyl-CoA-binding domain-containing protein 5; Binds medium- and long-chain acyl-CoA esters. (464 aa)
	rtn4	Reticulon. (1043 aa)
	A0A1L8G1T9	GB1/RHD3-type G domain-containing protein. (571 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (600 aa)
	rtn4-2	Reticulon. (1024 aa)
	atl2	GB1/RHD3-type G domain-containing protein. (569 aa)
	spast	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (595 aa)
	RTN3	Reticulon. (214 aa)
	tmcc1	Uncharacterized protein. (644 aa)
	A0A1L8GJR8	GB1/RHD3-type G domain-containing protein. (522 aa)
	Rtn3.L	Reticulon. (206 aa)
	tmcc1-2	Uncharacterized protein. (644 aa)
	lingo1	Ig-like domain-containing protein. (606 aa)
	lingo1-2	Ig-like domain-containing protein. (606 aa)
	reep4-2	Receptor expression-enhancing protein. (261 aa)
	A0A1L8H267	Uncharacterized protein. (642 aa)
	s1pr2-2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (349 aa)
	omg	LRRNT domain-containing protein. (427 aa)
	omg-2	LRRNT domain-containing protein. (427 aa)
	Rtn4r.S	Uncharacterized protein. (494 aa)
	prr16	Uncharacterized protein. (302 aa)
	reep1	Receptor expression-enhancing protein. (224 aa)
	Reep6.L	Receptor expression-enhancing protein. (254 aa)
	Vps13a.L	Uncharacterized protein. (3184 aa)
	Rtn4r.L	Uncharacterized protein. (494 aa)
	A0A310TP71	Uncharacterized protein. (440 aa)
	tmem33-2	Tmem33-prov protein. (247 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EZW3	A0A1L8G1T9	A0A1L8EZW3	A0A1L8G1T9	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.821
A0A1L8EZW3	A0A1L8GJR8	A0A1L8EZW3	A0A1L8GJR8	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.821
A0A1L8EZW3	A0A1L8H267	A0A1L8EZW3	A0A1L8H267	Uncharacterized protein.	Uncharacterized protein.	0.824
A0A1L8EZW3	RTN3	A0A1L8EZW3	A0A1L8GD96	Uncharacterized protein.	Reticulon.	0.632
A0A1L8EZW3	Rtn1.L	A0A1L8EZW3	A0A1L8FAE3	Uncharacterized protein.	Reticulon.	0.633
A0A1L8EZW3	Rtn1.S	A0A1L8EZW3	A0A1L8F043	Uncharacterized protein.	Reticulon.	0.633
A0A1L8EZW3	Rtn3.L	A0A1L8EZW3	A0A1L8GJY0	Uncharacterized protein.	Reticulon.	0.629
A0A1L8EZW3	SPAST	A0A1L8EZW3	A0A1L8G226	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.688
A0A1L8EZW3	Vapb.L	A0A1L8EZW3	A0A1L8ELN1	Uncharacterized protein.	MSP domain-containing protein.	0.541
A0A1L8EZW3	atl1	A0A1L8EZW3	A0A1L8F0B3	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.799
A0A1L8EZW3	atl1-2	A0A1L8EZW3	A0A1L8F9Q3	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.798
A0A1L8EZW3	atl2	A0A1L8EZW3	A0A1L8G7A9	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.793
A0A1L8EZW3	pdzd8	A0A1L8EZW3	A0A1L8FDT8	Uncharacterized protein.	Uncharacterized protein.	0.582
A0A1L8EZW3	reep1	A0A1L8EZW3	A0A1L8HT57	Uncharacterized protein.	Receptor expression-enhancing protein.	0.749
A0A1L8EZW3	rtn2	A0A1L8EZW3	A0A1L8F3E9	Uncharacterized protein.	Reticulon.	0.548
A0A1L8EZW3	rtn2-2	A0A1L8EZW3	A0A1L8F838	Uncharacterized protein.	Reticulon.	0.549
A0A1L8EZW3	rtn4	A0A1L8EZW3	A0A1L8G1I6	Uncharacterized protein.	Reticulon.	0.534
A0A1L8EZW3	rtn4-2	A0A1L8EZW3	A0A1L8G5R6	Uncharacterized protein.	Reticulon.	0.442
A0A1L8EZW3	spast	A0A1L8EZW3	A0A1L8G7L7	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.688
A0A1L8FAD2	A0A1L8G1T9	A0A1L8FAD2	A0A1L8G1T9	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.821