(12 nodes) Mixed, incl. Guanylate-binding protein, N-terminal, and Reticulon network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8EZW3	Uncharacterized protein. (777 aa)
	Rtn1.S	Reticulon. (752 aa)
	atl1	GB1/RHD3-type G domain-containing protein. (558 aa)
	atl1-2	GB1/RHD3-type G domain-containing protein. (558 aa)
	A0A1L8FAD2	Uncharacterized protein. (1361 aa)
	Rtn1.L	Reticulon. (768 aa)
	A0A1L8G1T9	GB1/RHD3-type G domain-containing protein. (571 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (600 aa)
	spast	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (595 aa)
	Rtn3.L	Reticulon. (206 aa)
	A0A1L8H267	Uncharacterized protein. (642 aa)
	reep1	Receptor expression-enhancing protein. (224 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EZW3	A0A1L8G1T9	A0A1L8EZW3	A0A1L8G1T9	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.821
A0A1L8EZW3	A0A1L8H267	A0A1L8EZW3	A0A1L8H267	Uncharacterized protein.	Uncharacterized protein.	0.824
A0A1L8EZW3	Rtn1.L	A0A1L8EZW3	A0A1L8FAE3	Uncharacterized protein.	Reticulon.	0.633
A0A1L8EZW3	Rtn1.S	A0A1L8EZW3	A0A1L8F043	Uncharacterized protein.	Reticulon.	0.633
A0A1L8EZW3	Rtn3.L	A0A1L8EZW3	A0A1L8GJY0	Uncharacterized protein.	Reticulon.	0.629
A0A1L8EZW3	SPAST	A0A1L8EZW3	A0A1L8G226	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.688
A0A1L8EZW3	atl1	A0A1L8EZW3	A0A1L8F0B3	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.799
A0A1L8EZW3	atl1-2	A0A1L8EZW3	A0A1L8F9Q3	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.798
A0A1L8EZW3	reep1	A0A1L8EZW3	A0A1L8HT57	Uncharacterized protein.	Receptor expression-enhancing protein.	0.749
A0A1L8EZW3	spast	A0A1L8EZW3	A0A1L8G7L7	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.688
A0A1L8FAD2	A0A1L8G1T9	A0A1L8FAD2	A0A1L8G1T9	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.821
A0A1L8FAD2	A0A1L8H267	A0A1L8FAD2	A0A1L8H267	Uncharacterized protein.	Uncharacterized protein.	0.824
A0A1L8FAD2	Rtn1.L	A0A1L8FAD2	A0A1L8FAE3	Uncharacterized protein.	Reticulon.	0.633
A0A1L8FAD2	Rtn1.S	A0A1L8FAD2	A0A1L8F043	Uncharacterized protein.	Reticulon.	0.633
A0A1L8FAD2	Rtn3.L	A0A1L8FAD2	A0A1L8GJY0	Uncharacterized protein.	Reticulon.	0.629
A0A1L8FAD2	SPAST	A0A1L8FAD2	A0A1L8G226	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.688
A0A1L8FAD2	atl1	A0A1L8FAD2	A0A1L8F0B3	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.799
A0A1L8FAD2	atl1-2	A0A1L8FAD2	A0A1L8F9Q3	Uncharacterized protein.	GB1/RHD3-type G domain-containing protein.	0.798
A0A1L8FAD2	reep1	A0A1L8FAD2	A0A1L8HT57	Uncharacterized protein.	Receptor expression-enhancing protein.	0.749
A0A1L8FAD2	spast	A0A1L8FAD2	A0A1L8G7L7	Uncharacterized protein.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.688