(42 nodes) Notch signaling pathway network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hes5.4	Hairy and enhancer of split 5. (159 aa)
	rfng	Beta-1,3-N-acetylglucosaminyltransferase. (364 aa)
	Lfng.L	Beta-1,3-N-acetylglucosaminyltransferase. (373 aa)
	jag2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1223 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	A0A1L8F3L0	Uncharacterized protein. (2377 aa)
	nrarp	ANK_REP_REGION domain-containing protein. (114 aa)
	notch1	Uncharacterized protein. (2521 aa)
	jag2-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1227 aa)
	dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (675 aa)
	hes5.7	BHLH domain-containing protein. (155 aa)
	hes5.9	BHLH domain-containing protein. (155 aa)
	hes5.6	BHLH domain-containing protein. (156 aa)
	hes5.8	Uncharacterized protein. (149 aa)
	hes5.5	Uncharacterized protein. (158 aa)
	hes5.9-2	BHLH domain-containing protein. (155 aa)
	hey1	Uncharacterized protein. (294 aa)
	hey1-2	Uncharacterized protein. (298 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	hes1	Uncharacterized protein. (267 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	hey2	Uncharacterized protein. (334 aa)
	hes1-2	Uncharacterized protein. (267 aa)
	A0A1L8GNN6	Uncharacterized protein. (2572 aa)
	A0A1L8GR86	MamL-1 domain-containing protein. (971 aa)
	A0A1L8GRM4	Uncharacterized protein. (2165 aa)
	A0A1L8H2E9	Uncharacterized protein. (2404 aa)
	maml2	MamL-1 domain-containing protein. (994 aa)
	maml2-2	MamL-1 domain-containing protein. (995 aa)
	Rbpj.S	Uncharacterized protein. (485 aa)
	A0A1L8HLU1	MamL-1 domain-containing protein. (1090 aa)
	rbpj	Uncharacterized protein. (487 aa)
	A0A1L8HUL3	Uncharacterized protein. (668 aa)
	LOC397855	Beta-1,3-N-acetylglucosaminyltransferase. (375 aa)
	XMam1	XMam1 protein. (1039 aa)
	hes5.5-2	Uncharacterized protein. (158 aa)
	X-Delta-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
	hes5.7-2	Enhancer of split related protein 9b. (154 aa)
	hes5.6-2	Enhancer of split related 9. (156 aa)
	hes5.3-2	Enhancer of split related 2. (183 aa)
	dll1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F3L0	A0A1L8GR86	A0A1L8F3L0	A0A1L8GR86	Uncharacterized protein.	MamL-1 domain-containing protein.	0.912
A0A1L8F3L0	A0A1L8GRM4	A0A1L8F3L0	A0A1L8GRM4	Uncharacterized protein.	Uncharacterized protein.	0.410
A0A1L8F3L0	A0A1L8H2E9	A0A1L8F3L0	A0A1L8H2E9	Uncharacterized protein.	Uncharacterized protein.	0.410
A0A1L8F3L0	A0A1L8HLU1	A0A1L8F3L0	A0A1L8HLU1	Uncharacterized protein.	MamL-1 domain-containing protein.	0.611
A0A1L8F3L0	A0A1L8HUL3	A0A1L8F3L0	A0A1L8HUL3	Uncharacterized protein.	Uncharacterized protein.	0.611
A0A1L8F3L0	Jag1.L	A0A1L8F3L0	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.988
A0A1L8F3L0	LOC397855	A0A1L8F3L0	B7ZQE6	Uncharacterized protein.	Beta-1,3-N-acetylglucosaminyltransferase.	0.937
A0A1L8F3L0	Lfng.L	A0A1L8F3L0	A0A1L8EXQ9	Uncharacterized protein.	Beta-1,3-N-acetylglucosaminyltransferase.	0.937
A0A1L8F3L0	Rbpj.S	A0A1L8F3L0	A0A1L8HL49	Uncharacterized protein.	Uncharacterized protein.	0.997
A0A1L8F3L0	X-Delta-2	A0A1L8F3L0	P79941	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.927
A0A1L8F3L0	XMam1	A0A1L8F3L0	B7ZQH4	Uncharacterized protein.	XMam1 protein.	0.935
A0A1L8F3L0	dll1	A0A1L8F3L0	A0A1L8G230	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.961
A0A1L8F3L0	dll1-2	A0A1L8F3L0	Q91902	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.961
A0A1L8F3L0	dll4	A0A1L8F3L0	A0A1L8FB19	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.986
A0A1L8F3L0	hes1	A0A1L8F3L0	A0A1L8G421	Uncharacterized protein.	Uncharacterized protein.	0.610
A0A1L8F3L0	hes1-2	A0A1L8F3L0	A0A1L8G9X1	Uncharacterized protein.	Uncharacterized protein.	0.648
A0A1L8F3L0	hes5.3-2	A0A1L8F3L0	Q90Z13	Uncharacterized protein.	Enhancer of split related 2.	0.532
A0A1L8F3L0	hes5.4	A0A1L8F3L0	A0A0U2KF03	Uncharacterized protein.	Hairy and enhancer of split 5.	0.536
A0A1L8F3L0	hes5.5	A0A1L8F3L0	A0A1L8FMI1	Uncharacterized protein.	Uncharacterized protein.	0.533
A0A1L8F3L0	hes5.5-2	A0A1L8F3L0	B7ZQH5	Uncharacterized protein.	Uncharacterized protein.	0.532