(25 nodes) NOTCH1 Intracellular Domain Regulates Transcription, and N terminus of Notch ligand C2-like domain network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	jag2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1223 aa)
	Notch1.S	Uncharacterized protein. (2524 aa)
	notch1	Uncharacterized protein. (2521 aa)
	jag2-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1227 aa)
	hes5.9	BHLH domain-containing protein. (155 aa)
	hes5.6	BHLH domain-containing protein. (156 aa)
	hes5.9-2	BHLH domain-containing protein. (155 aa)
	hey1	Uncharacterized protein. (294 aa)
	hey1-2	Uncharacterized protein. (298 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	hes1	Uncharacterized protein. (267 aa)
	Jag1.L	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	hey2	Uncharacterized protein. (334 aa)
	hes1-2	Uncharacterized protein. (267 aa)
	A0A1L8GRM4	Uncharacterized protein. (2165 aa)
	A0A1L8H2E9	Uncharacterized protein. (2404 aa)
	maml2	MamL-1 domain-containing protein. (994 aa)
	maml2-2	MamL-1 domain-containing protein. (995 aa)
	Rbpj.S	Uncharacterized protein. (485 aa)
	A0A1L8HLU1	MamL-1 domain-containing protein. (1090 aa)
	rbpj	Uncharacterized protein. (487 aa)
	A0A1L8HUL3	Uncharacterized protein. (668 aa)
	XMam1	XMam1 protein. (1039 aa)
	dll1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GRM4	A0A1L8H2E9	A0A1L8GRM4	A0A1L8H2E9	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A1L8GRM4	A0A1L8HLU1	A0A1L8GRM4	A0A1L8HLU1	Uncharacterized protein.	MamL-1 domain-containing protein.	0.669
A0A1L8GRM4	A0A1L8HUL3	A0A1L8GRM4	A0A1L8HUL3	Uncharacterized protein.	Uncharacterized protein.	0.669
A0A1L8GRM4	Jag1.L	A0A1L8GRM4	A0A1L8G723	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.988
A0A1L8GRM4	Notch1.S	A0A1L8GRM4	A0A1L8F124	Uncharacterized protein.	Uncharacterized protein.	0.590
A0A1L8GRM4	Rbpj.S	A0A1L8GRM4	A0A1L8HL49	Uncharacterized protein.	Uncharacterized protein.	0.997
A0A1L8GRM4	XMam1	A0A1L8GRM4	B7ZQH4	Uncharacterized protein.	XMam1 protein.	0.797
A0A1L8GRM4	dll1	A0A1L8GRM4	A0A1L8G230	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.922
A0A1L8GRM4	dll1-2	A0A1L8GRM4	Q91902	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.922
A0A1L8GRM4	hes1	A0A1L8GRM4	A0A1L8G421	Uncharacterized protein.	Uncharacterized protein.	0.671
A0A1L8GRM4	hes1-2	A0A1L8GRM4	A0A1L8G9X1	Uncharacterized protein.	Uncharacterized protein.	0.669
A0A1L8GRM4	hes5.6	A0A1L8GRM4	A0A1L8FGH4	Uncharacterized protein.	BHLH domain-containing protein.	0.537
A0A1L8GRM4	hes5.9	A0A1L8GRM4	A0A1L8FGG8	Uncharacterized protein.	BHLH domain-containing protein.	0.536
A0A1L8GRM4	hes5.9-2	A0A1L8GRM4	A0A1L8FML0	Uncharacterized protein.	BHLH domain-containing protein.	0.536
A0A1L8GRM4	hey1	A0A1L8GRM4	A0A1L8FTD9	Uncharacterized protein.	Uncharacterized protein.	0.599
A0A1L8GRM4	hey1-2	A0A1L8GRM4	A0A1L8FZB3	Uncharacterized protein.	Uncharacterized protein.	0.599
A0A1L8GRM4	hey2	A0A1L8GRM4	A0A1L8G8T5	Uncharacterized protein.	Uncharacterized protein.	0.601
A0A1L8GRM4	jag1	A0A1L8GRM4	A0A1L8G0P5	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.988
A0A1L8GRM4	jag2	A0A1L8GRM4	A0A1L8EZY8	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.974
A0A1L8GRM4	jag2-2	A0A1L8GRM4	A0A1L8FA43	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.974