5 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kremen2	Uncharacterized protein. (420 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	A0A1L8GQT6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GQT6	dkk1	A0A1L8GQT6	A0A1L8FIS6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf_N domain-containing protein.	0.999
A0A1L8GQT6	dkk2	A0A1L8GQT6	A0A1L8HM80	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf_N domain-containing protein.	0.988
A0A1L8GQT6	kremen1	A0A1L8GQT6	A0A1L8I1A4	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.882
A0A1L8GQT6	kremen2	A0A1L8GQT6	A0A1L8EYY0	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Uncharacterized protein.	0.876
dkk1	A0A1L8GQT6	A0A1L8FIS6	A0A1L8GQT6	Dickkopf_N domain-containing protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.999
dkk1	dkk2	A0A1L8FIS6	A0A1L8HM80	Dickkopf_N domain-containing protein.	Dickkopf_N domain-containing protein.	0.591
dkk1	kremen1	A0A1L8FIS6	A0A1L8I1A4	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.997
dkk1	kremen2	A0A1L8FIS6	A0A1L8EYY0	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.953
dkk2	A0A1L8GQT6	A0A1L8HM80	A0A1L8GQT6	Dickkopf_N domain-containing protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.988
dkk2	dkk1	A0A1L8HM80	A0A1L8FIS6	Dickkopf_N domain-containing protein.	Dickkopf_N domain-containing protein.	0.591
dkk2	kremen1	A0A1L8HM80	A0A1L8I1A4	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.979
dkk2	kremen2	A0A1L8HM80	A0A1L8EYY0	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.874
kremen1	A0A1L8GQT6	A0A1L8I1A4	A0A1L8GQT6	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.882
kremen1	dkk1	A0A1L8I1A4	A0A1L8FIS6	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf_N domain-containing protein.	0.997
kremen1	dkk2	A0A1L8I1A4	A0A1L8HM80	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf_N domain-containing protein.	0.979
kremen2	A0A1L8GQT6	A0A1L8EYY0	A0A1L8GQT6	Uncharacterized protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.876
kremen2	dkk1	A0A1L8EYY0	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.953
kremen2	dkk2	A0A1L8EYY0	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.874