(10 nodes) Mixed, incl. Chaperonin Cpn60/GroEL, and GroES chaperonin family network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hspe1	Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
	hspd1	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (576 aa)
	grpel2	Uncharacterized protein; Belongs to the GrpE family. (212 aa)
	Clpx.L	Uncharacterized protein. (624 aa)
	A0A1L8HJG3	ANK_REP_REGION domain-containing protein. (598 aa)
	Grpel1.L	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (216 aa)
	lonp1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (970 aa)
	clpp	ATP-dependent Clp protease proteolytic subunit. (247 aa)
	hspd1-2	Hspd1 protein; Belongs to the chaperonin (HSP60) family. (579 aa)
	hspe1-2	MGC79030 protein; Belongs to the GroES chaperonin family. (102 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8HJG3	Clpx.L	A0A1L8HJG3	A0A1L8H1C6	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.658
A0A1L8HJG3	Grpel1.L	A0A1L8HJG3	A0A1L8HT70	ANK_REP_REGION domain-containing protein.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.955
A0A1L8HJG3	clpp	A0A1L8HJG3	Q3KQF3	ANK_REP_REGION domain-containing protein.	ATP-dependent Clp protease proteolytic subunit.	0.997
A0A1L8HJG3	grpel2	A0A1L8HJG3	A0A1L8GV88	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the GrpE family.	0.954
A0A1L8HJG3	hspd1	A0A1L8HJG3	A0A1L8EX90	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.758
A0A1L8HJG3	hspd1-2	A0A1L8HJG3	Q6IP60	ANK_REP_REGION domain-containing protein.	Hspd1 protein; Belongs to the chaperonin (HSP60) family.	0.758
A0A1L8HJG3	hspe1	A0A1L8HJG3	A0A1L8EPX5	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the GroES chaperonin family.	0.905
A0A1L8HJG3	hspe1-2	A0A1L8HJG3	Q6NUG0	ANK_REP_REGION domain-containing protein.	MGC79030 protein; Belongs to the GroES chaperonin family.	0.905
A0A1L8HJG3	lonp1	A0A1L8HJG3	A0A1L8HXB6	ANK_REP_REGION domain-containing protein.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.931
Clpx.L	A0A1L8HJG3	A0A1L8H1C6	A0A1L8HJG3	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.658
Clpx.L	Grpel1.L	A0A1L8H1C6	A0A1L8HT70	Uncharacterized protein.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.707
Clpx.L	clpp	A0A1L8H1C6	Q3KQF3	Uncharacterized protein.	ATP-dependent Clp protease proteolytic subunit.	0.999
Clpx.L	grpel2	A0A1L8H1C6	A0A1L8GV88	Uncharacterized protein.	Uncharacterized protein; Belongs to the GrpE family.	0.876
Clpx.L	hspd1	A0A1L8H1C6	A0A1L8EX90	Uncharacterized protein.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.661
Clpx.L	hspd1-2	A0A1L8H1C6	Q6IP60	Uncharacterized protein.	Hspd1 protein; Belongs to the chaperonin (HSP60) family.	0.660
Clpx.L	hspe1	A0A1L8H1C6	A0A1L8EPX5	Uncharacterized protein.	Uncharacterized protein; Belongs to the GroES chaperonin family.	0.586
Clpx.L	hspe1-2	A0A1L8H1C6	Q6NUG0	Uncharacterized protein.	MGC79030 protein; Belongs to the GroES chaperonin family.	0.586
Clpx.L	lonp1	A0A1L8H1C6	A0A1L8HXB6	Uncharacterized protein.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.772
Grpel1.L	A0A1L8HJG3	A0A1L8HT70	A0A1L8HJG3	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	ANK_REP_REGION domain-containing protein.	0.955
Grpel1.L	Clpx.L	A0A1L8HT70	A0A1L8H1C6	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	Uncharacterized protein.	0.707