STRINGSTRING
telo2 telo2 pcna pcna tert tert Hus1 Hus1 mcrs1 mcrs1 apex1 apex1 ruvbl1-2 ruvbl1-2 rad51d rad51d tprkb tprkb ruvbl2 ruvbl2 TRF2 TRF2 fbxo4 fbxo4 LOC100049093 LOC100049093 lto1 lto1 tinf2 tinf2 Xrcc1.S Xrcc1.S A0A1L8I2B2 A0A1L8I2B2 tep1 tep1 A0A1L8HWC1 A0A1L8HWC1 wrn wrn gar1-2 gar1-2 znf827-2 znf827-2 A0A1L8HPV3 A0A1L8HPV3 Apex1.S Apex1.S smc5 smc5 Upf1.S Upf1.S gar1 gar1 znf827 znf827 mre11 mre11 brca2 brca2 Ptges3.L Ptges3.L A0A1L8HG81 A0A1L8HG81 dclre1b dclre1b Rpa1.L Rpa1.L Recql4.L Recql4.L A0A1L8H854 A0A1L8H854 A0A1L8H4R2 A0A1L8H4R2 wrap53 wrap53 A0A1L8H1D5 A0A1L8H1D5 Pot1.L Pot1.L rad50-2 rad50-2 rad50 rad50 A0A1L8GTX6 A0A1L8GTX6 dclre1c dclre1c blm blm ruvbl1 ruvbl1 parp3 parp3 Uchl5.L Uchl5.L Xrcc6.L Xrcc6.L PIF1 PIF1 ccne1 ccne1 uchl5 uchl5 Ccne1.S Ccne1.S terf2 terf2 Pinx1.L Pinx1.L A0A1L8GC51 A0A1L8GC51 Smc6.L Smc6.L Atr.L Atr.L Nsmce2.L Nsmce2.L Ccne2.L Ccne2.L Nbn.L Nbn.L Prkdc.L Prkdc.L A0A1L8FXS7 A0A1L8FXS7 A0A1L8FXH8 A0A1L8FXH8 Ccne2.S Ccne2.S A0A1L8FS70 A0A1L8FS70 Xrcc1.L Xrcc1.L A0A1L8FMY4 A0A1L8FMY4 Zbtb48.L Zbtb48.L A0A1L8FL85 A0A1L8FL85 ercc1 ercc1 znf365-2 znf365-2 Dclre1a.L Dclre1a.L A0A1L8FH84 A0A1L8FH84 A0A1L8FH77 A0A1L8FH77 A0A1L8FH67 A0A1L8FH67 A0A1L8FH58 A0A1L8FH58 A0A1L8FGQ7 A0A1L8FGQ7 A0A1L8FGI0 A0A1L8FGI0 Stn1.S Stn1.S ino80 ino80 rad51 rad51 xrcc3 xrcc3 Dkc1.L Dkc1.L slx4 slx4 Ercc4.L Ercc4.L Ino80d.L Ino80d.L Xrcc5.L Xrcc5.L terf2ip terf2ip ino80d ino80d rif1 rif1 A0A1L8EKP5 A0A1L8EKP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
telo2Telomere_reg-2 domain-containing protein. (835 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1191 aa)
Hus1Checkpoint protein; Belongs to the HUS1 family. (282 aa)
mcrs1Mcrs1-prov protein. (453 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (316 aa)
ruvbl1-2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
rad51dMGC82048 protein. (324 aa)
tprkbMGC80189 protein; Belongs to the CGI121/TPRKB family. (175 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (462 aa)
TRF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (468 aa)
fbxo4LOC100158284 protein. (384 aa)
LOC100049093LOC100049093 protein. (452 aa)
lto1LOC100037152 protein. (137 aa)
tinf2TRF1 interacting nuclear factor 2. (364 aa)
Xrcc1.SUncharacterized protein. (591 aa)
A0A1L8I2B2Uncharacterized protein. (248 aa)
tep1Uncharacterized protein. (2652 aa)
A0A1L8HWC1Uncharacterized protein. (1098 aa)
wrnUncharacterized protein. (1434 aa)
gar1-2H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (223 aa)
znf827-2Uncharacterized protein. (1317 aa)
A0A1L8HPV3Uncharacterized protein. (64 aa)
Apex1.SDNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (349 aa)
smc5AAA_15 domain-containing protein. (1063 aa)
Upf1.SUncharacterized protein. (1098 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (228 aa)
znf827Uncharacterized protein. (1317 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (711 aa)
brca2Tower domain-containing protein. (3177 aa)
Ptges3.LCS domain-containing protein. (218 aa)
A0A1L8HG81RECA_2 domain-containing protein. (375 aa)
dclre1bLactamase_B domain-containing protein. (519 aa)
Rpa1.LReplication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
Recql4.LUncharacterized protein. (1504 aa)
A0A1L8H854Uncharacterized protein. (98 aa)
A0A1L8H4R2Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
wrap53WD_REPEATS_REGION domain-containing protein. (654 aa)
A0A1L8H1D5Uncharacterized protein. (1367 aa)
Pot1.LTelo_bind domain-containing protein. (621 aa)
rad50-2Zinc-hook domain-containing protein. (1312 aa)
rad50Zinc-hook domain-containing protein. (1311 aa)
A0A1L8GTX6Uncharacterized protein; Belongs to the CGI121/TPRKB family. (175 aa)
dclre1cUncharacterized protein. (698 aa)
blmUncharacterized protein. (1368 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
parp3Poly [ADP-ribose] polymerase. (547 aa)
Uchl5.LUbiquitin carboxyl-terminal hydrolase. (329 aa)
Xrcc6.LKu domain-containing protein. (611 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (635 aa)
ccne1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
Ccne1.SCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
terf2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (466 aa)
Pinx1.LG-patch domain-containing protein. (352 aa)
A0A1L8GC51SMC_N domain-containing protein. (1130 aa)
Smc6.LSMC_N domain-containing protein. (1128 aa)
Atr.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
Nsmce2.LSP-RING-type domain-containing protein. (238 aa)
Ccne2.LCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa)
Nbn.LNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
Prkdc.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
A0A1L8FXS7Uncharacterized protein. (705 aa)
A0A1L8FXH8ATP-dependent DNA helicase; Belongs to the helicase family. (1558 aa)
Ccne2.SCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (430 aa)
A0A1L8FS70Uncharacterized protein. (704 aa)
Xrcc1.LUncharacterized protein. (651 aa)
A0A1L8FMY4Uncharacterized protein. (267 aa)
Zbtb48.LUncharacterized protein. (706 aa)
A0A1L8FL85NFRKB_winged domain-containing protein. (1263 aa)
ercc1Uncharacterized protein. (297 aa)
znf365-2Uncharacterized protein. (396 aa)
Dclre1a.LDRMBL domain-containing protein. (932 aa)
A0A1L8FH84RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (54 aa)
A0A1L8FH77RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (108 aa)
A0A1L8FH67RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (122 aa)
A0A1L8FH58RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (47 aa)
A0A1L8FGQ7Uncharacterized protein. (250 aa)
A0A1L8FGI0Uncharacterized protein. (766 aa)
Stn1.SUncharacterized protein. (492 aa)
ino80Uncharacterized protein. (1539 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
xrcc3RECA_2 domain-containing protein. (360 aa)
Dkc1.LPUA domain-containing protein. (558 aa)
slx4BTB domain-containing protein. (1773 aa)
Ercc4.LERCC4 domain-containing protein. (924 aa)
Ino80d.LUncharacterized protein. (1025 aa)
Xrcc5.LX-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (726 aa)
terf2ipUncharacterized protein. (513 aa)
ino80dUncharacterized protein. (1025 aa)
rif1Rif1_N domain-containing protein. (2326 aa)
A0A1L8EKP5Rap1_C domain-containing protein. (136 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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