(15 nodes) Release of cytochrome c from mitochondria network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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Your Input:
	A0A1L8FRI9	Uncharacterized protein. (189 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	A0A1L8H4Q1	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	Dnm1l.L	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (650 aa)
	MGC53884	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (698 aa)
	A0A1L8GJQ1	Uncharacterized protein. (151 aa)
	bok-2	Uncharacterized protein. (214 aa)
	bok	Uncharacterized protein. (214 aa)
	A0A1L8FXP7	BH4_2 domain-containing protein. (300 aa)
	A0A1L8ETJ8	Uncharacterized protein. (188 aa)
	A0A1L8ETS9	Uncharacterized protein. (106 aa)
	timm50	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (368 aa)
	timm50-2	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (368 aa)
	Bax.L	Uncharacterized protein. (221 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ETJ8	A0A1L8FRI9	A0A1L8ETJ8	A0A1L8FRI9	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A1L8FRI9	A0A1L8ETJ8	A0A1L8FRI9	A0A1L8ETJ8	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A1L8FXP7	A0A1L8GJQ1	A0A1L8FXP7	A0A1L8GJQ1	BH4_2 domain-containing protein.	Uncharacterized protein.	0.992
A0A1L8FXP7	A0A1L8H4Q1	A0A1L8FXP7	A0A1L8H4Q1	BH4_2 domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.845
A0A1L8FXP7	Bax.L	A0A1L8FXP7	A0A1L8FH04	BH4_2 domain-containing protein.	Uncharacterized protein.	0.996
A0A1L8FXP7	Bcl2.S	A0A1L8FXP7	A0A1L8FSA4	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.900
A0A1L8FXP7	Tp53.L	A0A1L8FXP7	A0A1L8H4M6	BH4_2 domain-containing protein.	P53 domain-containing protein.	0.845
A0A1L8GJQ1	A0A1L8FXP7	A0A1L8GJQ1	A0A1L8FXP7	Uncharacterized protein.	BH4_2 domain-containing protein.	0.992
A0A1L8GJQ1	Bax.L	A0A1L8GJQ1	A0A1L8FH04	Uncharacterized protein.	Uncharacterized protein.	0.746
A0A1L8GJQ1	Bcl2.S	A0A1L8GJQ1	A0A1L8FSA4	Uncharacterized protein.	BH4_2 domain-containing protein.	0.995
A0A1L8GJQ1	bok	A0A1L8GJQ1	A0A1L8G4M6	Uncharacterized protein.	Uncharacterized protein.	0.806
A0A1L8GJQ1	bok-2	A0A1L8GJQ1	A0A1L8GB63	Uncharacterized protein.	Uncharacterized protein.	0.806
A0A1L8H4Q1	A0A1L8FXP7	A0A1L8H4Q1	A0A1L8FXP7	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BH4_2 domain-containing protein.	0.845
A0A1L8H4Q1	Bax.L	A0A1L8H4Q1	A0A1L8FH04	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.740
A0A1L8H4Q1	Bcl2.S	A0A1L8H4Q1	A0A1L8FSA4	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BH4_2 domain-containing protein.	0.845
Bax.L	A0A1L8FXP7	A0A1L8FH04	A0A1L8FXP7	Uncharacterized protein.	BH4_2 domain-containing protein.	0.996
Bax.L	A0A1L8GJQ1	A0A1L8FH04	A0A1L8GJQ1	Uncharacterized protein.	Uncharacterized protein.	0.746
Bax.L	A0A1L8H4Q1	A0A1L8FH04	A0A1L8H4Q1	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.740
Bax.L	Bcl2.S	A0A1L8FH04	A0A1L8FSA4	Uncharacterized protein.	BH4_2 domain-containing protein.	0.996
Bax.L	Tp53.L	A0A1L8FH04	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.794