75 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8HET1	Uncharacterized protein. (250 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (316 aa)
	angel2	MGC115586 protein. (536 aa)
	Eri1.L	Uncharacterized protein. (385 aa)
	rad1	Uncharacterized protein. (283 aa)
	A0A1L8I1W2	Uncharacterized protein. (118 aa)
	rad9b	Cell cycle checkpoint control protein; Belongs to the rad9 family. (483 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2285 aa)
	wrn	Uncharacterized protein. (1434 aa)
	cnot6l	Endo/exonuclease/phosphatase domain-containing protein. (550 aa)
	noct	Endo/exonuclease/phosphatase domain-containing protein. (456 aa)
	A0A1L8HUC5	Endo/exonuclease/phosphatase domain-containing protein. (431 aa)
	Apex1.S	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (349 aa)
	A0A1L8HMM6	Uncharacterized protein. (280 aa)
	Cnot6l.S	Endo/exonuclease/phosphatase domain-containing protein. (584 aa)
	Noct.S	Endo/exonuclease/phosphatase domain-containing protein. (462 aa)
	cnot7	Uncharacterized protein. (285 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (711 aa)
	PAN2-2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1200 aa)
	dis3	Uncharacterized protein; Belongs to the RNR ribonuclease family. (953 aa)
	A0A1L8HEN9	Uncharacterized protein. (303 aa)
	A0A1L8H9U4	Uncharacterized protein. (320 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1200 aa)
	A0A1L8H8T5	Uncharacterized protein. (89 aa)
	A0A1L8H388	Uncharacterized protein. (246 aa)
	Dis3l.L	RNB domain-containing protein; Belongs to the RNR ribonuclease family. (1040 aa)
	polg	POLAc domain-containing protein. (1200 aa)
	A0A1L8GWV2	Uncharacterized protein. (289 aa)
	A0A1L8GVN0	Uncharacterized protein. (466 aa)
	A0A1L8GR62	Uncharacterized protein. (289 aa)
	A0A1L8GNX4	AP_endonuc_2 domain-containing protein. (400 aa)
	eri3	Exonuclease domain-containing protein. (321 aa)
	toe1-2	C3H1-type domain-containing protein. (515 aa)
	usb1	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (251 aa)
	pde12	Endo/exonuclease/phosphatase domain-containing protein. (565 aa)
	A0A1L8GFY6	Exonuclease domain-containing protein. (260 aa)
	toe1	C3H1-type domain-containing protein. (520 aa)
	A0A1L8GF12	Uncharacterized protein. (314 aa)
	A0A1L8G7Z8	Uncharacterized protein. (328 aa)
	aplf	Uncharacterized protein. (510 aa)
	A0A1L8G6I4	Endo/exonuclease/phosphatase domain-containing protein. (426 aa)
	dis3l2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1070 aa)
	A0A1L8G2M8	Uncharacterized protein. (132 aa)
	pnpt1	S1 motif domain-containing protein. (785 aa)
	Tatdn1.L	Uncharacterized protein. (297 aa)
	A0A1L8FXG3	Uncharacterized protein. (299 aa)
	A0A1L8FTZ1	Endo/exonuclease/phosphatase domain-containing protein. (844 aa)
	Pold1.L	DNA polymerase. (1109 aa)
	Rexo2.L	Exonuclease domain-containing protein. (219 aa)
	A0A1L8FKZ4	Uncharacterized protein. (77 aa)
	Exosc10.L	HRDC domain-containing protein. (628 aa)
	A0A1L8FKV3	Uncharacterized protein. (141 aa)
	A0A1L8FKH6	Uncharacterized protein. (136 aa)
	A0A1L8FJC0	Uncharacterized protein. (208 aa)
	A0A1L8FJ21	Uncharacterized protein. (448 aa)
	A0A1L8FF98	HRDC domain-containing protein. (717 aa)
	A0A1L8FDR9	Uncharacterized protein. (186 aa)
	exd2-2	3'-5' exonuclease domain-containing protein. (642 aa)
	angel1	Endo/exonuclease/phosphatase domain-containing protein. (567 aa)
	A0A1L8F6G0	Uncharacterized protein. (261 aa)
	Rexo4.L	Exonuclease domain-containing protein. (417 aa)
	exd3	3'-5' exonuclease domain-containing protein. (862 aa)
	A0A1L8F1Z7	Uncharacterized protein. (121 aa)
	trex2	Exonuclease domain-containing protein. (232 aa)
	rexo4	Exonuclease domain-containing protein. (421 aa)
	A0A1L8F0Z1	Uncharacterized protein. (47 aa)
	A0A1L8F0J3	Uncharacterized protein. (138 aa)
	exd2	3'-5' exonuclease domain-containing protein. (639 aa)
	Meiob.L	Uncharacterized protein. (470 aa)
	Eri2.L	Exonuclease domain-containing protein. (690 aa)
	Parn.L	R3H domain-containing protein. (631 aa)
	parn	R3H domain-containing protein. (632 aa)
	A0A1L8EN92	Endo/exonuclease/phosphatase domain-containing protein. (452 aa)
	A0A1L8EK50	Exonuclease domain-containing protein. (175 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EK50	A0A1L8FF98	A0A1L8EK50	A0A1L8FF98	Exonuclease domain-containing protein.	HRDC domain-containing protein.	0.420
A0A1L8EK50	A0A1L8FKV3	A0A1L8EK50	A0A1L8FKV3	Exonuclease domain-containing protein.	Uncharacterized protein.	0.420
A0A1L8EK50	A0A1L8FKZ4	A0A1L8EK50	A0A1L8FKZ4	Exonuclease domain-containing protein.	Uncharacterized protein.	0.420
A0A1L8EK50	Dis3l.L	A0A1L8EK50	A0A1L8H159	Exonuclease domain-containing protein.	RNB domain-containing protein; Belongs to the RNR ribonuclease family.	0.415
A0A1L8EK50	Exosc10.L	A0A1L8EK50	A0A1L8FKV5	Exonuclease domain-containing protein.	HRDC domain-containing protein.	0.420
A0A1L8EK50	dis3	A0A1L8EK50	A0A1L8HHD6	Exonuclease domain-containing protein.	Uncharacterized protein; Belongs to the RNR ribonuclease family.	0.415
A0A1L8EK50	dis3l2	A0A1L8EK50	A0A1L8G451	Exonuclease domain-containing protein.	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily.	0.415
A0A1L8EK50	mre11	A0A1L8EK50	A0A1L8HJD9	Exonuclease domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.906
A0A1L8EK50	pnpt1	A0A1L8EK50	A0A1L8G1M3	Exonuclease domain-containing protein.	S1 motif domain-containing protein.	0.454
A0A1L8EN92	A0A1L8FDR9	A0A1L8EN92	A0A1L8FDR9	Endo/exonuclease/phosphatase domain-containing protein.	Uncharacterized protein.	0.425
A0A1L8EN92	A0A1L8GNX4	A0A1L8EN92	A0A1L8GNX4	Endo/exonuclease/phosphatase domain-containing protein.	AP_endonuc_2 domain-containing protein.	0.614
A0A1L8EN92	Pold1.L	A0A1L8EN92	A0A1L8FNR6	Endo/exonuclease/phosphatase domain-containing protein.	DNA polymerase.	0.499
A0A1L8EN92	pole	A0A1L8EN92	A0A1L8HZP3	Endo/exonuclease/phosphatase domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.508
A0A1L8F1Z7	A0A1L8GNX4	A0A1L8F1Z7	A0A1L8GNX4	Uncharacterized protein.	AP_endonuc_2 domain-containing protein.	0.614
A0A1L8F1Z7	Pold1.L	A0A1L8F1Z7	A0A1L8FNR6	Uncharacterized protein.	DNA polymerase.	0.499
A0A1L8F1Z7	pole	A0A1L8F1Z7	A0A1L8HZP3	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.508
A0A1L8F6G0	A0A1L8GNX4	A0A1L8F6G0	A0A1L8GNX4	Uncharacterized protein.	AP_endonuc_2 domain-containing protein.	0.614
A0A1L8F6G0	Pold1.L	A0A1L8F6G0	A0A1L8FNR6	Uncharacterized protein.	DNA polymerase.	0.499
A0A1L8F6G0	pole	A0A1L8F6G0	A0A1L8HZP3	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.508
A0A1L8FDR9	A0A1L8EN92	A0A1L8FDR9	A0A1L8EN92	Uncharacterized protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.425