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| | Eya3.L | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (566 aa) |
| | A0A1L8EL88 | Protein kinase domain-containing protein. (697 aa) |
| | mfsd11 | Uncharacterized protein. (445 aa) |
| | nhej1 | Uncharacterized protein. (362 aa) |
| | tank | TBD domain-containing protein. (486 aa) |
| | A0A1L8EP79 | Uncharacterized protein. (788 aa) |
| | cdca7 | zf-4CXXC_R1 domain-containing protein. (431 aa) |
| | A0A1L8EPM6 | ANK_REP_REGION domain-containing protein. (400 aa) |
| | A0A1L8EQI7 | DCN1-like protein. (301 aa) |
| | A0A1L8ESG3 | Protein kinase domain-containing protein. (697 aa) |
| | Brca1.L | Uncharacterized protein. (1582 aa) |
| | A0A1L8EUJ5 | Uncharacterized protein. (445 aa) |
| | Xrcc5.L | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (726 aa) |
| | A0A1L8EVP6 | Uncharacterized protein. (289 aa) |
| | itgb6 | Integrin beta; Belongs to the integrin beta chain family. (780 aa) |
| | A0A1L8EW93 | Uncharacterized protein. (793 aa) |
| | bard1 | Uncharacterized protein. (839 aa) |
| | brat1 | Uncharacterized protein. (823 aa) |
| | dcun1d3 | DCN1-like protein. (341 aa) |
| | Elk1.S | ETS domain-containing protein. (469 aa) |
| | tgfb1 | Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa) |
| | A0A1L8F537 | Uncharacterized protein. (965 aa) |
| | A0A1L8F5L4 | ETS domain-containing protein. (412 aa) |
| | brcc3 | MPN domain-containing protein. (261 aa) |
| | tgfb1-2 | Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa) |
| | ino80 | Uncharacterized protein. (1539 aa) |
| | ints3 | Uncharacterized protein. (1018 aa) |
| | sirt1 | Deacetylase sirtuin-type domain-containing protein. (722 aa) |
| | Lzic.S | ICAT domain-containing protein. (182 aa) |
| | Cryab.S | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (167 aa) |
| | Bax.L | Uncharacterized protein. (221 aa) |
| | Sirt1.L | Deacetylase sirtuin-type domain-containing protein. (722 aa) |
| | ercc1 | Uncharacterized protein. (297 aa) |
| | ercc6 | Uncharacterized protein. (1370 aa) |
| | lzic | ICAT domain-containing protein. (190 aa) |
| | A0A1L8FLS9 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (194 aa) |
| | A0A1L8FPV0 | Uncharacterized protein. (145 aa) |
| | A0A1L8FQI2 | Uncharacterized protein. (76 aa) |
| | Xrcc2.S | RECA_2 domain-containing protein. (223 aa) |
| | Bcl2.S | BH4_2 domain-containing protein. (253 aa) |
| | A0A1L8FTT4 | BHLH domain-containing protein. (191 aa) |
| | Myc.S | Myc_N domain-containing protein. (176 aa) |
| | A0A1L8FV52 | RECA_2 domain-containing protein. (213 aa) |
| | A0A1L8FW69 | Uncharacterized protein. (279 aa) |
| | topbp1 | Uncharacterized protein. (1573 aa) |
| | A0A1L8FXP7 | BH4_2 domain-containing protein. (300 aa) |
| | A0A1L8FXP8 | Uncharacterized protein. (349 aa) |
| | Spidr.L | Uncharacterized protein. (866 aa) |
| | A0A1L8FZI8 | Uncharacterized protein. (855 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa) |
| | Ints7.S | Uncharacterized protein. (978 aa) |
| | Abcg5.S | ABC transporter domain-containing protein. (657 aa) |
| | Ect2.S | Uncharacterized protein. (987 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa) |
| | Bre.L | Uncharacterized protein. (404 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (532 aa) |
| | ect2 | Uncharacterized protein. (986 aa) |
| | Atr.L | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa) |
| | rnf168-2 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa) |
| | rfwd3 | RING-type domain-containing protein. (750 aa) |
| | kars | Lysine--tRNA ligase. (611 aa) |
| | A0A1L8GFT3 | Uncharacterized protein. (791 aa) |
| | cop1 | Uncharacterized protein. (681 aa) |
| | A0A1L8GGJ1 | Uncharacterized protein. (1173 aa) |
| | Men1.L | Uncharacterized protein. (675 aa) |
| | Kars.L | Lysine--tRNA ligase. (605 aa) |
| | rfwd3-2 | RING-type domain-containing protein. (751 aa) |
| | cop1-2 | Uncharacterized protein. (682 aa) |
| | A0A1L8GN98 | Uncharacterized protein. (1290 aa) |
| | Xrcc6.L | Ku domain-containing protein. (611 aa) |
| | fancd2 | Uncharacterized protein. (1445 aa) |
| | ikbip | Uncharacterized protein. (388 aa) |
| | Rhno1.S | Uncharacterized protein. (252 aa) |
| | Tigar.S | Uncharacterized protein. (275 aa) |
| | polb | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (334 aa) |
| | blm | Uncharacterized protein. (1368 aa) |
| | ticrr | Treslin_N domain-containing protein. (1968 aa) |
| | A0A1L8GSW6 | Uncharacterized protein. (2175 aa) |
| | net1 | Uncharacterized protein. (584 aa) |
| | A0A1L8GWA8 | Uncharacterized protein. (209 aa) |
| | A0A1L8GY09 | RAP80_UIM domain-containing protein. (937 aa) |
| | net1-2 | Uncharacterized protein. (583 aa) |
| | tp53bp1 | Uncharacterized protein. (2179 aa) |
| | Ticrr.L | Treslin_N domain-containing protein. (1985 aa) |
| | A0A1L8H1D5 | Uncharacterized protein. (1367 aa) |
| | Tp53.L | P53 domain-containing protein. (137 aa) |
| | A0A1L8H4Q1 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa) |
| | A0A1L8H7I8 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | A0A1L8H7W7 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (739 aa) |
| | A0A1L8H827 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (441 aa) |
| | nabp2 | OB domain-containing protein. (203 aa) |
| | tankl | TBD domain-containing protein. (271 aa) |
| | kdm1a | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (830 aa) |
| | zmpste24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa) |
| | nabp2-2 | OB domain-containing protein. (203 aa) |
| | brca2 | Tower domain-containing protein. (3177 aa) |
| | smpd1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (581 aa) |
| | xrra1 | Uncharacterized protein. (713 aa) |
| | stk11 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa) |
| | anxa1.2 | Annexin. (338 aa) |
| | abraxas1 | MPN domain-containing protein. (408 aa) |
| | A0A1L8HRR4 | Nipped-B protein. (1728 aa) |
| | sfrp2 | Uncharacterized protein. (295 aa) |
| | A0A1L8HVY7 | Uncharacterized protein. (326 aa) |
| | wrn | Uncharacterized protein. (1434 aa) |
| | stk11-2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa) |
| | babam1 | Uncharacterized protein. (328 aa) |
| | A0A1L8HY95 | Annexin. (338 aa) |
| | A0A1L8HYC9 | Annexin. (242 aa) |
| | A0A1L8I081 | Uncharacterized protein. (96 aa) |
| | Chek2.L | Uncharacterized protein. (392 aa) |
| | rad9b | Cell cycle checkpoint control protein; Belongs to the rad9 family. (483 aa) |
| | A0A1L8I1K3 | Uncharacterized protein. (275 aa) |
| | A0A1L8I1T7 | Uncharacterized protein. (335 aa) |
| | rad1 | Uncharacterized protein. (283 aa) |
| | nipbl | Nipped-B protein. (2844 aa) |
| | fbxo4 | LOC100158284 protein. (384 aa) |
| | tank-2 | TRAF family member-associated NF-kappaB activator. (484 aa) |
| | nucks1 | Uncharacterized protein. (291 aa) |
| | nucks1-2 | JC7 protein. (293 aa) |
| | ercc8 | LOC496353 protein. (399 aa) |
| | prkaa1 | Non-specific serine/threonine protein kinase. (560 aa) |
| | anxa1.3 | Annexin. (363 aa) |
| | anxa1.1 | Annexin. (343 aa) |
| | lig4 | DNA ligase. (911 aa) |
| | myc | Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa) |
| | anxa1.1-2 | Annexin. (343 aa) |
| | sfrp2-2 | Sfrp2-prov protein. (298 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa) |
| | prkaa2 | Non-specific serine/threonine protein kinase. (560 aa) |
