(19 nodes) Multicellular organism aging network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
	ednra-2	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	sec63	MGC80164 protein. (755 aa)
	gna13-2	Heterotrimeric guanine nucleotide binding protein subunit alpha-13. (377 aa)
	edn1	LOC100158354 protein. (221 aa)
	ednra	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	Rnf165.L	RING-type domain-containing protein. (348 aa)
	wrn	Uncharacterized protein. (1434 aa)
	helt	Uncharacterized protein. (252 aa)
	Rnf165.S	RING-type domain-containing protein. (348 aa)
	A0A1L8H1B6	G_PROTEIN_RECEP_F1_2 domain-containing protein. (489 aa)
	A0A1L8GS75	G_PROTEIN_RECEP_F1_2 domain-containing protein. (489 aa)
	slc1a2	Amino acid transporter. (568 aa)
	Slc1a2.S	Amino acid transporter. (503 aa)
	tp63-2	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
	Sec63.L	J domain-containing protein. (737 aa)
	A0A1L8FNJ4	Amino acid transporter. (557 aa)
	ercc1	Uncharacterized protein. (297 aa)
	gna13	Uncharacterized protein. (377 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8GS75	edn1	A0A1L8GS75	Q08B43	G_PROTEIN_RECEP_F1_2 domain-containing protein.	LOC100158354 protein.	0.644
A0A1L8GS75	gna13	A0A1L8GS75	A0A1L8EV46	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.960
A0A1L8GS75	gna13-2	A0A1L8GS75	Q5HZN4	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Heterotrimeric guanine nucleotide binding protein subunit alpha-13.	0.960
A0A1L8H1B6	edn1	A0A1L8H1B6	Q08B43	G_PROTEIN_RECEP_F1_2 domain-containing protein.	LOC100158354 protein.	0.644
A0A1L8H1B6	gna13	A0A1L8H1B6	A0A1L8EV46	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.960
A0A1L8H1B6	gna13-2	A0A1L8H1B6	Q5HZN4	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Heterotrimeric guanine nucleotide binding protein subunit alpha-13.	0.960
Sec63.L	sec63	A0A1L8G8W1	Q6GQC5	J domain-containing protein.	MGC80164 protein.	0.900
edn1	A0A1L8GS75	Q08B43	A0A1L8GS75	LOC100158354 protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.644
edn1	A0A1L8H1B6	Q08B43	A0A1L8H1B6	LOC100158354 protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.644
edn1	ednra	Q08B43	A1L2P6	LOC100158354 protein.	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family.	0.999
edn1	ednra-2	Q08B43	Q7ZXQ5	LOC100158354 protein.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
ednra	edn1	A1L2P6	Q08B43	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family.	LOC100158354 protein.	0.999
ednra	ednra-2	A1L2P6	Q7ZXQ5	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.900
ednra	gna13	A1L2P6	A0A1L8EV46	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.933
ednra	gna13-2	A1L2P6	Q5HZN4	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family.	Heterotrimeric guanine nucleotide binding protein subunit alpha-13.	0.933
ednra-2	edn1	Q7ZXQ5	Q08B43	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	LOC100158354 protein.	0.999
ednra-2	ednra	Q7ZXQ5	A1L2P6	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family.	0.900
ednra-2	gna13	Q7ZXQ5	A0A1L8EV46	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.933
ednra-2	gna13-2	Q7ZXQ5	Q5HZN4	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Heterotrimeric guanine nucleotide binding protein subunit alpha-13.	0.933
ercc1	wrn	A0A1L8FKK3	A0A1L8HWA9	Uncharacterized protein.	Uncharacterized protein.	0.909