(136 nodes) Positive regulation of autophagy network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sesn3	Uncharacterized protein. (484 aa)
	Pip4k2a.S	PIPK domain-containing protein. (412 aa)
	Wipi1.S	Uncharacterized protein. (442 aa)
	snx4	PX domain-containing protein. (485 aa)
	rab3gap1	Uncharacterized protein. (980 aa)
	sh3bp4	Uncharacterized protein. (957 aa)
	A0A1L8EQW8	Rap-GAP domain-containing protein. (1705 aa)
	smcr8	UDENN FLCN/SMCR8-type domain-containing protein. (940 aa)
	Flcn.S	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	Pip4k2b.L	PIPK domain-containing protein. (416 aa)
	A0A1L8ES53	C2H2-type domain-containing protein. (476 aa)
	tp53inp2	Uncharacterized protein. (223 aa)
	Wipi1.L	Uncharacterized protein. (442 aa)
	snx4-2	PX domain-containing protein. (476 aa)
	Rab3gap1.L	Uncharacterized protein. (978 aa)
	sh3bp4-2	Uncharacterized protein. (957 aa)
	A0A1L8EYJ5	Rap-GAP domain-containing protein. (1746 aa)
	smcr8-2	UDENN FLCN/SMCR8-type domain-containing protein. (1010 aa)
	lrsam1	Uncharacterized protein. (726 aa)
	A0A1L8F139	Uncharacterized protein. (660 aa)
	tsc1	Uncharacterized protein. (1104 aa)
	A0A1L8F3P2	Uncharacterized protein. (314 aa)
	Supt5h.S	Transcription elongation factor SPT5. (1078 aa)
	lrsam1-2	Uncharacterized protein. (726 aa)
	gpsm1	Uncharacterized protein. (639 aa)
	tsc1-2	Uncharacterized protein. (1102 aa)
	trim32	Uncharacterized protein. (649 aa)
	bag3	Uncharacterized protein. (527 aa)
	A0A1L8FEJ8	RING-type domain-containing protein. (551 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (722 aa)
	Pafah1b2.S	SGNH_hydro domain-containing protein. (229 aa)
	gsk3a	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (424 aa)
	bnip3	Uncharacterized protein. (196 aa)
	Sirt1.L	Deacetylase sirtuin-type domain-containing protein. (722 aa)
	vps13d	Uncharacterized protein. (4359 aa)
	A0A1L8FN20	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (422 aa)
	wac	WW domain-containing protein. (631 aa)
	A0A1L8FQS5	PIPK domain-containing protein. (405 aa)
	nod1	Uncharacterized protein. (946 aa)
	Rnf152.S	RING-type domain-containing protein. (203 aa)
	Rock1.S	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1367 aa)
	rb1cc1	ATG11 domain-containing protein. (1573 aa)
	ripk2	Uncharacterized protein. (550 aa)
	Tp53inp1.S	Uncharacterized protein. (237 aa)
	wac-2	WW domain-containing protein. (652 aa)
	A0A1L8FVK8	PIPK domain-containing protein. (405 aa)
	rnf152	RING-type domain-containing protein. (203 aa)
	Rock1.L	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
	rb1cc1-2	ATG11 domain-containing protein. (1573 aa)
	A0A1L8FZB6	RING-type domain-containing protein. (643 aa)
	ripk2-2	Uncharacterized protein. (545 aa)
	tp53inp1	Uncharacterized protein. (237 aa)
	A0A1L8G1S4	Uncharacterized protein. (705 aa)
	bcl2l11	Uncharacterized protein. (194 aa)
	A0A1L8G2R0	Uncharacterized protein. (110 aa)
	Sesn1.S	Uncharacterized protein. (481 aa)
	foxo3	Fork-head domain-containing protein. (656 aa)
	rab3gap2	Uncharacterized protein. (1390 aa)
	bcl2l11-2	Uncharacterized protein. (194 aa)
	A0A1L8G7L5	Uncharacterized protein. (708 aa)
	Epm2a.L	Uncharacterized protein. (317 aa)
	sesn1	Uncharacterized protein. (481 aa)
	A0A1L8G9G9	Uncharacterized protein. (111 aa)
	Foxo3.L	Fork-head domain-containing protein. (661 aa)
	ufl1	Uncharacterized protein. (795 aa)
	ambra1	WD_REPEATS_REGION domain-containing protein. (1304 aa)
	svip	Uncharacterized protein. (81 aa)
	plekhf1	Uncharacterized protein. (269 aa)
	A0A1L8GFI4	Non-specific serine/threonine protein kinase. (551 aa)
	Tmem59.S	Uncharacterized protein. (345 aa)
	atf6	BZIP domain-containing protein. (635 aa)
	nprl2	Uncharacterized protein. (383 aa)
	atg2a	Uncharacterized protein. (1997 aa)
	A0A1L8GKF8	Uncharacterized protein. (1010 aa)
	A0A1L8GKL1	Uncharacterized protein. (495 aa)
	A0A1L8GM16	Non-specific serine/threonine protein kinase. (551 aa)
	Tmem59.L	Uncharacterized protein. (342 aa)
	A0A1L8GMI4	Uncharacterized protein. (206 aa)
	snx7	PX domain-containing protein. (442 aa)
	A0A1L8GMU8	Uncharacterized protein. (306 aa)
	atf6-2	BZIP domain-containing protein. (646 aa)
	fbxo7	F-box domain-containing protein. (500 aa)
	larp1	HTH La-type RNA-binding domain-containing protein. (1015 aa)
	A0A1L8GRD3	Uncharacterized protein. (343 aa)
	A0A1L8GRY7	Uncharacterized protein. (183 aa)
	A0A1L8GUI6	Uncharacterized protein. (183 aa)
	ifng	Uncharacterized protein. (182 aa)
	lrrk2	Uncharacterized protein. (2514 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	tfeb	BHLH domain-containing protein. (435 aa)
	A0A1L8H7F6	Uncharacterized protein. (449 aa)
	zc3h12a	C3H1-type domain-containing protein. (637 aa)
	A0A1L8H818	Protein kinase domain-containing protein. (1055 aa)
	atg101	Uncharacterized protein. (218 aa)
	Pip4k2c.S	PIPK domain-containing protein. (481 aa)
	foxo1	Fork-head domain-containing protein. (626 aa)
	A0A1L8HBT3	Uncharacterized protein. (28 aa)
	A0A1L8HBT4	Protein kinase domain-containing protein. (64 aa)
	A0A1L8HBY8	Protein kinase domain-containing protein. (298 aa)
	zc3h12a-2	C3H1-type domain-containing protein. (644 aa)
	ulk2	Protein kinase domain-containing protein. (1073 aa)
	atg101-2	Uncharacterized protein. (218 aa)
	pip4k2c	PIPK domain-containing protein. (475 aa)
	foxo1-2	Fork-head domain-containing protein. (631 aa)
	kdr	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1326 aa)
	Scoc.S	Uncharacterized protein. (172 aa)
	stk11	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	rnf31	Uncharacterized protein. (1057 aa)
	A0A1L8HQ99	DEP domain-containing protein. (1582 aa)
	Ulk1.S	Protein kinase domain-containing protein. (967 aa)
	hspb8	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (203 aa)
	A0A1L8HTA9	Uncharacterized protein. (3120 aa)
	A0A1L8HTZ2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
	A0A1L8HUI7	Uncharacterized protein. (142 aa)
	stk11-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	snx30	PX domain-containing protein. (451 aa)
	Sptlc1.L	Aminotran_1_2 domain-containing protein. (472 aa)
	Tpcn1.L	Uncharacterized protein. (823 aa)
	A0A1L8I0B3	DEP domain-containing protein. (1583 aa)
	ulk1	Protein kinase domain-containing protein. (1049 aa)
	Hspb8.L	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (203 aa)
	Tp53inp2.S	Uncharacterized protein. (225 aa)
	LOC496290	LOC496290 protein. (461 aa)
	trim8	LOC100127258 protein. (551 aa)
	larp1-2	MGC98945 protein. (1021 aa)
	pafah1b2	LOC495446 protein. (229 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (560 aa)
	dcn	Decorin; May affect the rate of fibrils formation. (364 aa)
	dcn-2	Decorin; May affect the rate of fibrils formation. (364 aa)
	sesn3-2	MGC80167 protein. (480 aa)
	snx7-2	MGC80047 protein. (435 aa)
	sesn2	MGC81239 protein. (413 aa)
	bnip3-2	MGC68574 protein. (202 aa)
	nprl3	MGC68624 protein. (580 aa)
	bag3-2	Bag3-A protein. (597 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (560 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EQW8	A0A1L8EYJ5	A0A1L8EQW8	A0A1L8EYJ5	Rap-GAP domain-containing protein.	Rap-GAP domain-containing protein.	0.900
A0A1L8EQW8	A0A1L8FN20	A0A1L8EQW8	A0A1L8FN20	Rap-GAP domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.458
A0A1L8EQW8	A0A1L8GFI4	A0A1L8EQW8	A0A1L8GFI4	Rap-GAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.965
A0A1L8EQW8	A0A1L8GM16	A0A1L8EQW8	A0A1L8GM16	Rap-GAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.965
A0A1L8EQW8	A0A1L8H5Q6	A0A1L8EQW8	A0A1L8H5Q6	Rap-GAP domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.943
A0A1L8EQW8	A0A1L8HBT3	A0A1L8EQW8	A0A1L8HBT3	Rap-GAP domain-containing protein.	Uncharacterized protein.	0.458
A0A1L8EQW8	A0A1L8HBT4	A0A1L8EQW8	A0A1L8HBT4	Rap-GAP domain-containing protein.	Protein kinase domain-containing protein.	0.458
A0A1L8EQW8	A0A1L8HBY8	A0A1L8EQW8	A0A1L8HBY8	Rap-GAP domain-containing protein.	Protein kinase domain-containing protein.	0.458
A0A1L8EQW8	Flcn.S	A0A1L8EQW8	A0A1L8EQZ5	Rap-GAP domain-containing protein.	UDENN FLCN/SMCR8-type domain-containing protein.	0.554
A0A1L8EQW8	Sirt1.L	A0A1L8EQW8	A0A1L8FJP8	Rap-GAP domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.444
A0A1L8EQW8	gsk3a	A0A1L8EQW8	A0A1L8FGT4	Rap-GAP domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.458
A0A1L8EQW8	nprl2	A0A1L8EQW8	A0A1L8GHF2	Rap-GAP domain-containing protein.	Uncharacterized protein.	0.563
A0A1L8EQW8	nprl3	A0A1L8EQW8	Q6PB11	Rap-GAP domain-containing protein.	MGC68624 protein.	0.564
A0A1L8EQW8	prkaa1	A0A1L8EQW8	Q5U5E3	Rap-GAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.968
A0A1L8EQW8	prkaa2	A0A1L8EQW8	Q8UVW8	Rap-GAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.968
A0A1L8EQW8	rb1cc1	A0A1L8EQW8	A0A1L8FT26	Rap-GAP domain-containing protein.	ATG11 domain-containing protein.	0.447
A0A1L8EQW8	rb1cc1-2	A0A1L8EQW8	A0A1L8FYZ6	Rap-GAP domain-containing protein.	ATG11 domain-containing protein.	0.447
A0A1L8EQW8	sirt1	A0A1L8EQW8	A0A1L8FEV8	Rap-GAP domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.444
A0A1L8EQW8	stk11	A0A1L8EQW8	A0A1L8HNA4	Rap-GAP domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.840
A0A1L8EQW8	stk11-2	A0A1L8EQW8	A0A1L8HWM5	Rap-GAP domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.840