(36 nodes) Regulation of peptidyl-threonine phosphorylation network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8HBT4	Protein kinase domain-containing protein. (64 aa)
	A0A1L8HBY8	Protein kinase domain-containing protein. (298 aa)
	App.L	BPTI/Kunitz inhibitor domain-containing protein. (749 aa)
	inpp5k	IPPc domain-containing protein. (476 aa)
	smad7	Mothers against decapentaplegic homolog. (382 aa)
	A0A1L8HTL9	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
	dgkq	Diacylglycerol kinase. (956 aa)
	Stox1.L	Stork_head domain-containing protein. (981 aa)
	ube2k	Ube2k protein; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	smad7-2	Mothers against decapentaplegic homolog. (382 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	A0A1L8ETH9	WD_REPEATS_REGION domain-containing protein. (1350 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	Spred1.S	WH1 domain-containing protein. (223 aa)
	Wnk3.S	Protein kinase domain-containing protein. (2749 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Spred1.L	Uncharacterized protein. (405 aa)
	stox1	Stork_head domain-containing protein. (977 aa)
	ddit4	Uncharacterized protein. (219 aa)
	gsk3a	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (424 aa)
	Sirt2.S	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (402 aa)
	ddit4-2	Uncharacterized protein. (219 aa)
	A0A1L8FN20	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (422 aa)
	Cadm4.L	Uncharacterized protein. (365 aa)
	pard3	Uncharacterized protein. (1369 aa)
	ripk2	Uncharacterized protein. (550 aa)
	pard3-2	Uncharacterized protein. (1332 aa)
	ripk2-2	Uncharacterized protein. (545 aa)
	A0A1L8GKL1	Uncharacterized protein. (495 aa)
	A0A1L8GRT2	HP domain-containing protein. (365 aa)
	dmtn	HP domain-containing protein. (412 aa)
	A0A1L8H564	BPTI/Kunitz inhibitor domain-containing protein. (751 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	A0A1L8H6C5	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (418 aa)
	A0A1L8HBT3	Uncharacterized protein. (28 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ETH9	ddit4	A0A1L8ETH9	A0A1L8FF07	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.525
A0A1L8ETH9	ddit4-2	A0A1L8ETH9	A0A1L8FJV2	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.525
A0A1L8GKL1	ripk2	A0A1L8GKL1	A0A1L8FTF9	Uncharacterized protein.	Uncharacterized protein.	0.909
A0A1L8GKL1	ripk2-2	A0A1L8GKL1	A0A1L8FZI7	Uncharacterized protein.	Uncharacterized protein.	0.908
A0A1L8H564	tgfb1	A0A1L8H564	A0A1L8F3Y7	BPTI/Kunitz inhibitor domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.456
A0A1L8H564	tgfb1-2	A0A1L8H564	A0A1L8F936	BPTI/Kunitz inhibitor domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.456
A0A1L8H5Q6	App.L	A0A1L8H5Q6	A0A1L8HCN6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BPTI/Kunitz inhibitor domain-containing protein.	0.411
App.L	A0A1L8H5Q6	A0A1L8HCN6	A0A1L8H5Q6	BPTI/Kunitz inhibitor domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.411
App.L	tgfb1	A0A1L8HCN6	A0A1L8F3Y7	BPTI/Kunitz inhibitor domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.456
App.L	tgfb1-2	A0A1L8HCN6	A0A1L8F936	BPTI/Kunitz inhibitor domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.456
Plk1.S	plk1	A0A1L8EQN7	A0A1L8EYC7	Serine/threonine-protein kinase PLK.	Serine/threonine-protein kinase PLK.	0.900
ddit4	A0A1L8ETH9	A0A1L8FF07	A0A1L8ETH9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.525
ddit4	ddit4-2	A0A1L8FF07	A0A1L8FJV2	Uncharacterized protein.	Uncharacterized protein.	0.900
ddit4-2	A0A1L8ETH9	A0A1L8FJV2	A0A1L8ETH9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.525
ddit4-2	ddit4	A0A1L8FJV2	A0A1L8FF07	Uncharacterized protein.	Uncharacterized protein.	0.900
dgkq	inpp5k	A0A1L8HXB1	A0A1L8HDR5	Diacylglycerol kinase.	IPPc domain-containing protein.	0.564
inpp5k	dgkq	A0A1L8HDR5	A0A1L8HXB1	IPPc domain-containing protein.	Diacylglycerol kinase.	0.564
plk1	Plk1.S	A0A1L8EYC7	A0A1L8EQN7	Serine/threonine-protein kinase PLK.	Serine/threonine-protein kinase PLK.	0.900
ripk2	A0A1L8GKL1	A0A1L8FTF9	A0A1L8GKL1	Uncharacterized protein.	Uncharacterized protein.	0.909
ripk2	ripk2-2	A0A1L8FTF9	A0A1L8FZI7	Uncharacterized protein.	Uncharacterized protein.	0.900