STRINGSTRING
top3a top3a trim16 trim16 Sumo1.S Sumo1.S usp7 usp7 ciita ciita tp53inp2 tp53inp2 Sumo1.L Sumo1.L A0A1L8EXF3 A0A1L8EXF3 usp7-2 usp7-2 A0A1L8F2G2 A0A1L8F2G2 A0A1L8F6Y3 A0A1L8F6Y3 atrx atrx Daxx.L Daxx.L rad51 rad51 A0A1L8FEJ8 A0A1L8FEJ8 sirt1 sirt1 Ankrd2.S Ankrd2.S A0A1L8FG23 A0A1L8FG23 ski ski Ankrd2.L Ankrd2.L Sirt1.L Sirt1.L A0A1L8FKW5 A0A1L8FKW5 A0A1L8FLW6 A0A1L8FLW6 ski-2 ski-2 A0A1L8FM62 A0A1L8FM62 A0A1L8FM90 A0A1L8FM90 A0A1L8FM96 A0A1L8FM96 Tdp2.S Tdp2.S Tp53inp1.S Tp53inp1.S eif3e eif3e topbp1 topbp1 A0A1L8FY07 A0A1L8FY07 Nbn.L Nbn.L tp53inp1 tp53inp1 EIF3E EIF3E Nsmce2.L Nsmce2.L A0A1L8G343 A0A1L8G343 A0A1L8G3G8 A0A1L8G3G8 A0A1L8G9L8 A0A1L8G9L8 A0A1L8G9R4 A0A1L8G9R4 Atr.L Atr.L Smc6.L Smc6.L A0A1L8GC51 A0A1L8GC51 hipk3 hipk3 rfwd3 rfwd3 n4bp1 n4bp1 klhl20 klhl20 Arntl.L Arntl.L hipk3-2 hipk3-2 N4bp1.L N4bp1.L rfwd3-2 rfwd3-2 A0A1L8GMU8 A0A1L8GMU8 klhl20-2 klhl20-2 A0A1L8GQN9 A0A1L8GQN9 blm blm Rnf111-b Rnf111-b Nr2c1.S Nr2c1.S Tdg.S Tdg.S nr2c1 nr2c1 rnf111 rnf111 A0A1L8H1D5 A0A1L8H1D5 Tp53.L Tp53.L A0A1L8H4Q1 A0A1L8H4Q1 A0A1L8H4R2 A0A1L8H4R2 Morc3.S Morc3.S A0A1L8H5E2 A0A1L8H5E2 rpain rpain rb1 rb1 Nfe2.S Nfe2.S Morc3.2.L Morc3.2.L A0A1L8HCG3 A0A1L8HCG3 A0A1L8HCI9 A0A1L8HCI9 Rpa1.L Rpa1.L rpain-2 rpain-2 nfe2 nfe2 ppargc1a ppargc1a topors topors smc5 smc5 A0A1L8HQH5 A0A1L8HQH5 Pias2.S Pias2.S Rnf4-a Rnf4-a ppargc1a-2 ppargc1a-2 A0A1L8HVK2 A0A1L8HVK2 A0A1L8HVL5 A0A1L8HVL5 A0A1L8HVM4 A0A1L8HVM4 A0A1L8HVN2 A0A1L8HVN2 A0A1L8HVN6 A0A1L8HVN6 A0A1L8HVP0 A0A1L8HVP0 A0A1L8HVP9 A0A1L8HVP9 A0A1L8HVQ0 A0A1L8HVQ0 A0A1L8HVU3 A0A1L8HVU3 A0A1L8HW02 A0A1L8HW02 A0A1L8HW13 A0A1L8HW13 topors-2 topors-2 A0A1L8I081 A0A1L8I081 Chek2.L Chek2.L chfr chfr Pias2.L Pias2.L Tp53inp2.S Tp53inp2.S trim8 trim8 basp1 basp1 rnf4 rnf4 basp1-2 basp1-2 arntl arntl trim16-2 trim16-2 sqstm1 sqstm1 tert tert
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1022 aa)
trim16Uncharacterized protein. (563 aa)
Sumo1.SUbiquitin-like domain-containing protein. (141 aa)
usp7Uncharacterized protein; Belongs to the peptidase C19 family. (1123 aa)
ciitaNACHT domain-containing protein. (1047 aa)
tp53inp2Uncharacterized protein. (223 aa)
Sumo1.LUbiquitin-like domain-containing protein. (148 aa)
A0A1L8EXF3NACHT domain-containing protein. (1062 aa)
usp7-2Usp7; Belongs to the peptidase C19 family. (1124 aa)
A0A1L8F2G2PHD-type domain-containing protein. (1187 aa)
A0A1L8F6Y3SprT-like domain-containing protein. (596 aa)
atrxUncharacterized protein. (2276 aa)
Daxx.LDaxx domain-containing protein. (911 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
A0A1L8FEJ8RING-type domain-containing protein. (551 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (722 aa)
Ankrd2.SANK_REP_REGION domain-containing protein. (392 aa)
A0A1L8FG23Uncharacterized protein. (658 aa)
skic-SKI_SMAD_bind domain-containing protein. (717 aa)
Ankrd2.LANK_REP_REGION domain-containing protein. (311 aa)
Sirt1.LDeacetylase sirtuin-type domain-containing protein. (722 aa)
A0A1L8FKW5Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2533 aa)
A0A1L8FLW6Uncharacterized protein. (660 aa)
ski-2c-SKI_SMAD_bind domain-containing protein. (717 aa)
A0A1L8FM62RING-type domain-containing protein. (306 aa)
A0A1L8FM90RING-type domain-containing protein. (301 aa)
A0A1L8FM96RING-type domain-containing protein. (289 aa)
Tdp2.SEndo/exonuclease/phosphatase domain-containing protein. (382 aa)
Tp53inp1.SUncharacterized protein. (237 aa)
eif3eEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (446 aa)
topbp1Uncharacterized protein. (1573 aa)
A0A1L8FY07RING-type domain-containing protein. (199 aa)
Nbn.LNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
tp53inp1Uncharacterized protein. (237 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (409 aa)
Nsmce2.LSP-RING-type domain-containing protein. (238 aa)
A0A1L8G343Uncharacterized protein. (1788 aa)
A0A1L8G3G8Uncharacterized protein. (855 aa)
A0A1L8G9L8Uncharacterized protein. (851 aa)
A0A1L8G9R4Uncharacterized protein. (1695 aa)
Atr.LUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
Smc6.LSMC_N domain-containing protein. (1128 aa)
A0A1L8GC51SMC_N domain-containing protein. (1130 aa)
hipk3Protein kinase domain-containing protein. (1222 aa)
rfwd3RING-type domain-containing protein. (750 aa)
n4bp1RNase_Zc3h12a domain-containing protein. (861 aa)
klhl20BTB domain-containing protein. (609 aa)
Arntl.LUncharacterized protein. (627 aa)
hipk3-2Protein kinase domain-containing protein. (1214 aa)
N4bp1.LRNase_Zc3h12a domain-containing protein. (848 aa)
rfwd3-2RING-type domain-containing protein. (751 aa)
A0A1L8GMU8Uncharacterized protein. (306 aa)
klhl20-2BTB domain-containing protein. (604 aa)
A0A1L8GQN9Protein kinase domain-containing protein. (1137 aa)
blmUncharacterized protein. (1368 aa)
Rnf111-bRNF111_N domain-containing protein. (921 aa)
Nr2c1.SUncharacterized protein. (637 aa)
Tdg.SUDG domain-containing protein. (440 aa)
nr2c1Uncharacterized protein. (637 aa)
rnf111RING-type domain-containing protein. (975 aa)
A0A1L8H1D5Uncharacterized protein. (1367 aa)
Tp53.LP53 domain-containing protein. (137 aa)
A0A1L8H4Q1Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa)
A0A1L8H4R2Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
Morc3.SCW-type domain-containing protein. (896 aa)
A0A1L8H5E2CW-type domain-containing protein. (963 aa)
rpainUncharacterized protein. (226 aa)
rb1Uncharacterized protein. (899 aa)
Nfe2.SBZIP domain-containing protein. (370 aa)
Morc3.2.LCW-type domain-containing protein. (903 aa)
A0A1L8HCG3Morc6_S5 domain-containing protein. (586 aa)
A0A1L8HCI9CW-type domain-containing protein. (754 aa)
Rpa1.LReplication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
rpain-2Uncharacterized protein. (220 aa)
nfe2BZIP domain-containing protein. (351 aa)
ppargc1aRRM domain-containing protein. (784 aa)
toporsRING-type domain-containing protein. (1015 aa)
smc5AAA_15 domain-containing protein. (1063 aa)
A0A1L8HQH5Uncharacterized protein. (621 aa)
Pias2.SUncharacterized protein. (616 aa)
Rnf4-aRING-type domain-containing protein. (190 aa)
ppargc1a-2RRM domain-containing protein. (786 aa)
A0A1L8HVK2Uncharacterized protein. (216 aa)
A0A1L8HVL5Uncharacterized protein. (226 aa)
A0A1L8HVM4Uncharacterized protein. (175 aa)
A0A1L8HVN2Uncharacterized protein. (223 aa)
A0A1L8HVN6Uncharacterized protein. (187 aa)
A0A1L8HVP0Uncharacterized protein. (59 aa)
A0A1L8HVP9BEACH domain-containing protein. (215 aa)
A0A1L8HVQ0Uncharacterized protein. (213 aa)
A0A1L8HVU3Uncharacterized protein. (216 aa)
A0A1L8HW02Uncharacterized protein. (335 aa)
A0A1L8HW13Uncharacterized protein. (632 aa)
topors-2RING-type domain-containing protein. (1014 aa)
A0A1L8I081Uncharacterized protein. (96 aa)
Chek2.LUncharacterized protein. (392 aa)
chfrUncharacterized protein. (625 aa)
Pias2.LUncharacterized protein. (584 aa)
Tp53inp2.SUncharacterized protein. (225 aa)
trim8LOC100127258 protein. (551 aa)
basp1MGC132184 protein. (236 aa)
rnf4LOC495944 protein. (190 aa)
basp1-2MGC84072 protein. (235 aa)
arntlARNTL protein. (627 aa)
trim16-2MGC84103 protein. (563 aa)
sqstm1MGC64432 protein. (454 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1191 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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