(14 nodes) Chloride channel inhibitor activity network (Xenopus laevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	Stx8.S	t-SNARE coiled-coil homology domain-containing protein. (236 aa)
	vamp8-2	LOC496218 protein. (105 aa)
	Vti1b.L	t-SNARE coiled-coil homology domain-containing protein. (189 aa)
	vti1b	t-SNARE coiled-coil homology domain-containing protein. (221 aa)
	A0A1L8H1M3	V-SNARE coiled-coil homology domain-containing protein. (95 aa)
	vamp8	V-SNARE coiled-coil homology domain-containing protein. (107 aa)
	cftr-2	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
	vamp5	V-SNARE coiled-coil homology domain-containing protein. (99 aa)
	A0A1L8GQX6	Protein kinase domain-containing protein. (2191 aa)
	Wnk1.S	Uncharacterized protein. (265 aa)
	Wnk3.S	Protein kinase domain-containing protein. (2749 aa)
	wnk4-2	Protein kinase domain-containing protein. (1575 aa)
	wnk4	Protein kinase domain-containing protein. (1573 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8H1M3	Stx8.S	A0A1L8H1M3	A0A1L8EN61	V-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.672
A0A1L8H1M3	Vti1b.L	A0A1L8H1M3	A0A1L8HEQ7	V-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.643
A0A1L8H1M3	vamp8	A0A1L8H1M3	A0A1L8H1L5	V-SNARE coiled-coil homology domain-containing protein.	V-SNARE coiled-coil homology domain-containing protein.	0.536
A0A1L8H1M3	vamp8-2	A0A1L8H1M3	Q5M7F0	V-SNARE coiled-coil homology domain-containing protein.	LOC496218 protein.	0.536
A0A1L8H1M3	vti1b	A0A1L8H1M3	A0A1L8H759	V-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.643
Stx8.S	A0A1L8H1M3	A0A1L8EN61	A0A1L8H1M3	t-SNARE coiled-coil homology domain-containing protein.	V-SNARE coiled-coil homology domain-containing protein.	0.672
Stx8.S	Vti1b.L	A0A1L8EN61	A0A1L8HEQ7	t-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.994
Stx8.S	vamp5	A0A1L8EN61	A0A1L8GRY9	t-SNARE coiled-coil homology domain-containing protein.	V-SNARE coiled-coil homology domain-containing protein.	0.672
Stx8.S	vamp8	A0A1L8EN61	A0A1L8H1L5	t-SNARE coiled-coil homology domain-containing protein.	V-SNARE coiled-coil homology domain-containing protein.	0.995
Stx8.S	vamp8-2	A0A1L8EN61	Q5M7F0	t-SNARE coiled-coil homology domain-containing protein.	LOC496218 protein.	0.995
Stx8.S	vti1b	A0A1L8EN61	A0A1L8H759	t-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.999
Vti1b.L	A0A1L8H1M3	A0A1L8HEQ7	A0A1L8H1M3	t-SNARE coiled-coil homology domain-containing protein.	V-SNARE coiled-coil homology domain-containing protein.	0.643
Vti1b.L	Stx8.S	A0A1L8HEQ7	A0A1L8EN61	t-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.994
Vti1b.L	vamp5	A0A1L8HEQ7	A0A1L8GRY9	t-SNARE coiled-coil homology domain-containing protein.	V-SNARE coiled-coil homology domain-containing protein.	0.643
Vti1b.L	vamp8	A0A1L8HEQ7	A0A1L8H1L5	t-SNARE coiled-coil homology domain-containing protein.	V-SNARE coiled-coil homology domain-containing protein.	0.902
Vti1b.L	vamp8-2	A0A1L8HEQ7	Q5M7F0	t-SNARE coiled-coil homology domain-containing protein.	LOC496218 protein.	0.902
Vti1b.L	vti1b	A0A1L8HEQ7	A0A1L8H759	t-SNARE coiled-coil homology domain-containing protein.	t-SNARE coiled-coil homology domain-containing protein.	0.901
Wnk1.S	Wnk3.S	A0A1L8GQQ4	A0A1L8F1U7	Uncharacterized protein.	Protein kinase domain-containing protein.	0.693
Wnk1.S	cftr	A0A1L8GQQ4	A0A1L8GU84	Uncharacterized protein.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.477
Wnk1.S	cftr-2	A0A1L8GQQ4	A0A1L8GYY2	Uncharacterized protein.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.478