(59 nodes) Osteoclast differentiation network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Efna2.L	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (198 aa)
	fam20c	Fam20C domain-containing protein. (571 aa)
	A0A1L8ESH5	DC_STAMP domain-containing protein. (436 aa)
	A0A1L8EX51	Uncharacterized protein. (327 aa)
	Fam20c.L	Fam20C domain-containing protein. (571 aa)
	Atp6ap1.2.S	Uncharacterized protein. (463 aa)
	A0A1L8F0F3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	tnf	TNF_2 domain-containing protein. (227 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	atp6ap1.2	Uncharacterized protein. (463 aa)
	A0A1L8F8T7	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	sh3pxd2a	Uncharacterized protein. (1121 aa)
	G50	Uncharacterized protein. (980 aa)
	Sh3pxd2a.L	Uncharacterized protein. (1113 aa)
	Epha2.L	Uncharacterized protein. (948 aa)
	calcr	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (476 aa)
	Snx10.S	PX domain-containing protein. (205 aa)
	A0A1L8FSE2	TNFR-Cys domain-containing protein. (579 aa)
	tmem64	Uncharacterized protein. (307 aa)
	A0A1L8FVV6	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (535 aa)
	A0A1L8FXM9	TNFR-Cys domain-containing protein. (573 aa)
	tmem64-2	Uncharacterized protein. (315 aa)
	A0A1L8FZS0	DC_STAMP domain-containing protein. (493 aa)
	Glo1.S	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (153 aa)
	ostm1	Uncharacterized protein. (303 aa)
	farp2	FERM domain-containing protein. (712 aa)
	A0A1L8G6G4	VOC domain-containing protein. (108 aa)
	ostm1-2	Uncharacterized protein. (302 aa)
	A0A1L8GB78	Uncharacterized protein. (955 aa)
	Traf6.S	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	Tcta.S	T-cell leukemia translocation-altered gene protein homolog. (103 aa)
	Traf6.L	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	A0A1L8GNQ7	Fam20C domain-containing protein. (525 aa)
	A0A1L8GPC0	Uncharacterized protein. (116 aa)
	A0A1L8GRA0	Protein kinase domain-containing protein. (178 aa)
	A0A1L8GRA4	Ig-like domain-containing protein. (129 aa)
	A0A1L8GRE4	Ig-like domain-containing protein. (163 aa)
	Atp6ap1.1.S	Uncharacterized protein. (454 aa)
	A0A1L8GYX3	Uncharacterized protein. (453 aa)
	lrrk1	Uncharacterized protein. (2003 aa)
	Junb.L	BZIP domain-containing protein. (306 aa)
	Nf1.S	Uncharacterized protein. (2774 aa)
	A0A1L8H9B3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
	gab2	PH domain-containing protein. (673 aa)
	nf1	Uncharacterized protein. (2759 aa)
	A0A1L8HH85	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	Tnfsf11.L	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (290 aa)
	gab2-2	PH domain-containing protein. (677 aa)
	Efna2.S	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (198 aa)
	tnf-2	Tumor necrosis factor alpha. (225 aa)
	fos	BZIP domain-containing protein. (369 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	fos-2	MGC80305 protein. (368 aa)
	snx10	MGC80910 protein. (205 aa)
	mgc69520	MGC81231 protein; Belongs to the G-protein coupled receptor 1 family. (345 aa)
	ctnnb1-2	Ctnnb1-prov protein. (781 aa)
	creb1	Creb1-prov protein. (324 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ESH5	A0A1L8FZS0	A0A1L8ESH5	A0A1L8FZS0	DC_STAMP domain-containing protein.	DC_STAMP domain-containing protein.	0.578
A0A1L8EX51	Junb.L	A0A1L8EX51	A0A1L8H2X9	Uncharacterized protein.	BZIP domain-containing protein.	0.436
A0A1L8EX51	ctnnb1	A0A1L8EX51	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.415
A0A1L8EX51	ctnnb1-2	A0A1L8EX51	Q7ZX35	Uncharacterized protein.	Ctnnb1-prov protein.	0.415
A0A1L8EX51	fos	A0A1L8EX51	A9UMM6	Uncharacterized protein.	BZIP domain-containing protein.	0.574
A0A1L8EX51	fos-2	A0A1L8EX51	Q6AXA4	Uncharacterized protein.	MGC80305 protein.	0.574
A0A1L8FSE2	A0A1L8FXM9	A0A1L8FSE2	A0A1L8FXM9	TNFR-Cys domain-containing protein.	TNFR-Cys domain-containing protein.	0.901
A0A1L8FSE2	Tnfsf11.L	A0A1L8FSE2	A0A1L8HHK6	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.997
A0A1L8FSE2	Traf6.L	A0A1L8FSE2	A0A1L8GIM0	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
A0A1L8FSE2	Traf6.S	A0A1L8FSE2	A0A1L8GE35	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
A0A1L8FSE2	tnfsf11	A0A1L8FSE2	A0A1L8H9C6	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.997
A0A1L8FVV6	A0A1L8FZS0	A0A1L8FVV6	A0A1L8FZS0	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	DC_STAMP domain-containing protein.	0.416
A0A1L8FXM9	A0A1L8FSE2	A0A1L8FXM9	A0A1L8FSE2	TNFR-Cys domain-containing protein.	TNFR-Cys domain-containing protein.	0.901
A0A1L8FXM9	Tnfsf11.L	A0A1L8FXM9	A0A1L8HHK6	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.997
A0A1L8FXM9	Traf6.L	A0A1L8FXM9	A0A1L8GIM0	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
A0A1L8FXM9	Traf6.S	A0A1L8FXM9	A0A1L8GE35	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
A0A1L8FXM9	tnfsf11	A0A1L8FXM9	A0A1L8H9C6	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.997
A0A1L8FZS0	A0A1L8ESH5	A0A1L8FZS0	A0A1L8ESH5	DC_STAMP domain-containing protein.	DC_STAMP domain-containing protein.	0.578
A0A1L8FZS0	A0A1L8FVV6	A0A1L8FZS0	A0A1L8FVV6	DC_STAMP domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.416
A0A1L8FZS0	Tnfsf11.L	A0A1L8FZS0	A0A1L8HHK6	DC_STAMP domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.540