(23 nodes) Rough endoplasmic reticulum membrane network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	plod1	Fe2OG dioxygenase domain-containing protein. (722 aa)
	sec61b	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	sec61a1-2	Sec61a1 protein. (476 aa)
	sec63	MGC80164 protein. (755 aa)
	rps28p9	MGC85550 protein. (69 aa)
	maco1	Uncharacterized protein. (661 aa)
	zc3h12a-2	C3H1-type domain-containing protein. (644 aa)
	A0A1L8HCM3	Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (171 aa)
	Tmem57.S	Uncharacterized protein. (661 aa)
	zc3h12a	C3H1-type domain-containing protein. (637 aa)
	sec61a1	Plug_translocon domain-containing protein. (476 aa)
	A0A1L8GN21	SUN domain-containing protein. (1388 aa)
	suco	SUN domain-containing protein. (1235 aa)
	Sec63.L	J domain-containing protein. (737 aa)
	Epm2a.L	Uncharacterized protein. (317 aa)
	srprb	Uncharacterized protein. (265 aa)
	sec61g	Uncharacterized protein. (68 aa)
	srpra	SRP54 domain-containing protein. (651 aa)
	Plod1.L	Fe2OG dioxygenase domain-containing protein. (755 aa)
	pi4kb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (819 aa)
	Pi4kb.S	PIK helical domain-containing protein; Belongs to the PI3/PI4-kinase family. (573 aa)
	ccdc47	Uncharacterized protein. (488 aa)
	Ccdc47.S	Uncharacterized protein. (489 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccdc47.S	Sec63.L	A0A1L8EL63	A0A1L8G8W1	Uncharacterized protein.	J domain-containing protein.	0.422
Ccdc47.S	sec61a1	A0A1L8EL63	A0A1L8GPS0	Uncharacterized protein.	Plug_translocon domain-containing protein.	0.801
Ccdc47.S	sec61a1-2	A0A1L8EL63	Q7ZX87	Uncharacterized protein.	Sec61a1 protein.	0.801
Ccdc47.S	sec61b	A0A1L8EL63	Q8AVT7	Uncharacterized protein.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.842
Ccdc47.S	sec61g	A0A1L8EL63	A0A1L8FWK5	Uncharacterized protein.	Uncharacterized protein.	0.840
Ccdc47.S	sec63	A0A1L8EL63	Q6GQC5	Uncharacterized protein.	MGC80164 protein.	0.422
Pi4kb.S	pi4kb	A0A1L8F577	A0A1L8FDA7	PIK helical domain-containing protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
Sec63.L	Ccdc47.S	A0A1L8G8W1	A0A1L8EL63	J domain-containing protein.	Uncharacterized protein.	0.422
Sec63.L	ccdc47	A0A1L8G8W1	A0A1L8ESF0	J domain-containing protein.	Uncharacterized protein.	0.422
Sec63.L	sec61a1	A0A1L8G8W1	A0A1L8GPS0	J domain-containing protein.	Plug_translocon domain-containing protein.	0.997
Sec63.L	sec61a1-2	A0A1L8G8W1	Q7ZX87	J domain-containing protein.	Sec61a1 protein.	0.997
Sec63.L	sec61b	A0A1L8G8W1	Q8AVT7	J domain-containing protein.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.995
Sec63.L	sec61g	A0A1L8G8W1	A0A1L8FWK5	J domain-containing protein.	Uncharacterized protein.	0.992
Sec63.L	sec63	A0A1L8G8W1	Q6GQC5	J domain-containing protein.	MGC80164 protein.	0.900
Sec63.L	srpra	A0A1L8G8W1	A0A1L8FLC6	J domain-containing protein.	SRP54 domain-containing protein.	0.690
Sec63.L	srprb	A0A1L8G8W1	A0A1L8G4Y8	J domain-containing protein.	Uncharacterized protein.	0.634
ccdc47	Sec63.L	A0A1L8ESF0	A0A1L8G8W1	Uncharacterized protein.	J domain-containing protein.	0.422
ccdc47	sec61a1	A0A1L8ESF0	A0A1L8GPS0	Uncharacterized protein.	Plug_translocon domain-containing protein.	0.801
ccdc47	sec61a1-2	A0A1L8ESF0	Q7ZX87	Uncharacterized protein.	Sec61a1 protein.	0.801
ccdc47	sec61b	A0A1L8ESF0	Q8AVT7	Uncharacterized protein.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.842