83 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8FR84	Uncharacterized protein. (220 aa)
	A0A1L8EJY7	Uncharacterized protein. (68 aa)
	A0A1L8EKH9	STAT_int domain-containing protein. (635 aa)
	A0A1L8ELB7	SEC7 domain-containing protein. (1794 aa)
	Stat3.2.L	Signal transducer and activator of transcription. (760 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	A0A1L8ESK4	SEC7 domain-containing protein. (1791 aa)
	ifih1	Uncharacterized protein. (996 aa)
	rasgrp1	Uncharacterized protein. (814 aa)
	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	A0A1L8F0R1	C-type lectin domain-containing protein. (378 aa)
	card9	CARD domain-containing protein. (527 aa)
	sash3	Uncharacterized protein. (391 aa)
	A0A1L8F4B9	Uncharacterized protein. (1020 aa)
	Arhgef2.S	Uncharacterized protein. (1003 aa)
	card9-2	CARD domain-containing protein. (527 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	rasgrp1-2	Uncharacterized protein. (811 aa)
	Thbs2.L	Uncharacterized protein. (1176 aa)
	arhgef2	Uncharacterized protein. (984 aa)
	A0A1L8FFJ7	Uncharacterized protein. (457 aa)
	A0A1L8FHP3	TIR domain-containing protein. (476 aa)
	A0A1L8FKX7	Uncharacterized protein. (165 aa)
	A0A1L8FL04	TIR domain-containing protein. (213 aa)
	A0A1L8FL21	TIR domain-containing protein. (202 aa)
	A0A1L8FPF3	TIR domain-containing protein. (270 aa)
	Myd88.S	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	nod1	Uncharacterized protein. (946 aa)
	ripk1	Uncharacterized protein. (666 aa)
	A0A1L8FTB8	ML domain-containing protein. (127 aa)
	ripk2	Uncharacterized protein. (550 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (283 aa)
	A0A1L8FW11	Uncharacterized protein. (139 aa)
	A0A1L8FXS1	Uncharacterized protein. (581 aa)
	ripk2-2	Uncharacterized protein. (545 aa)
	Akap12.S	Uncharacterized protein. (2427 aa)
	A0A1L8G7E2	Uncharacterized protein. (2374 aa)
	C1qtnf4.S	Uncharacterized protein. (418 aa)
	A0A1L8GE00	Uncharacterized protein. (1294 aa)
	A0A1L8GG25	Uncharacterized protein. (1252 aa)
	A0A1L8GGJ1	Uncharacterized protein. (1173 aa)
	A0A1L8GI68	Uncharacterized protein. (337 aa)
	A0A1L8GI80	Uncharacterized protein. (1175 aa)
	fadd	Uncharacterized protein. (188 aa)
	A0A1L8GJ05	Uncharacterized protein. (363 aa)
	frmd8	FERM domain-containing protein. (452 aa)
	A0A1L8GKF8	Uncharacterized protein. (1010 aa)
	A0A1L8GKL1	Uncharacterized protein. (495 aa)
	Cyba.L	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (187 aa)
	A0A1L8GMQ0	Uncharacterized protein. (1244 aa)
	A0A1L8GN98	Uncharacterized protein. (1290 aa)
	tlr9	TIR domain-containing protein; Belongs to the Toll-like receptor family. (830 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (316 aa)
	A0A1L8GX03	Uncharacterized protein. (467 aa)
	lrrk2	Uncharacterized protein. (2514 aa)
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	A0A1L8H564	BPTI/Kunitz inhibitor domain-containing protein. (751 aa)
	zbtb20	Uncharacterized protein. (750 aa)
	A0A1L8H5Q5	Ig-like domain-containing protein. (365 aa)
	A0A1L8H5V4	Uncharacterized protein. (271 aa)
	Hspb1.S	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (263 aa)
	A0A1L8HBP4	Ig-like domain-containing protein. (424 aa)
	A0A1L8HBQ1	Uncharacterized protein. (378 aa)
	A0A1L8HBS0	Ig-like domain-containing protein. (381 aa)
	A0A1L8HBY6	Ig-like domain-containing protein. (373 aa)
	zbtb20-2	Uncharacterized protein. (768 aa)
	Setd4.L	SET domain-containing protein. (456 aa)
	App.L	BPTI/Kunitz inhibitor domain-containing protein. (749 aa)
	Hspb1.L	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (272 aa)
	A0A1L8HKI7	CARD_2 domain-containing protein. (384 aa)
	spon2	Spondin domain-containing protein. (345 aa)
	Syk.S	Tyrosine-protein kinase. (632 aa)
	nfatc4	RHD domain-containing protein. (1086 aa)
	spon2-2	Spondin domain-containing protein. (345 aa)
	A0A1L8HTX4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (896 aa)
	syk	Tyrosine-protein kinase. (605 aa)
	nfatc4-2	RHD domain-containing protein. (1081 aa)
	sash3-2	LOC100049772 protein. (386 aa)
	lep-2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	fadd-2	Fas-associating death domain-containing protein. (188 aa)
	LOC495118	LOC495118 protein; Belongs to the protein kinase superfamily. (374 aa)
	timd4	MGC99322 protein. (224 aa)
	mapkapk2	MGC78852 protein; Belongs to the protein kinase superfamily. (377 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EJY7	A0A1L8HKI7	A0A1L8EJY7	A0A1L8HKI7	Uncharacterized protein.	CARD_2 domain-containing protein.	0.556
A0A1L8EJY7	Myd88.S	A0A1L8EJY7	A0A1L8FQF6	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.734
A0A1L8EJY7	myd88	A0A1L8EJY7	A0A1L8FV26	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.734
A0A1L8EKH9	A0A1L8FR84	A0A1L8EKH9	A0A1L8FR84	STAT_int domain-containing protein.	Uncharacterized protein.	0.655
A0A1L8EKH9	A0A1L8FW11	A0A1L8EKH9	A0A1L8FW11	STAT_int domain-containing protein.	Uncharacterized protein.	0.769
A0A1L8EKH9	IL12B	A0A1L8EKH9	A0A1L8GR16	STAT_int domain-containing protein.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.518
A0A1L8EKH9	Syk.S	A0A1L8EKH9	A0A1L8HPI7	STAT_int domain-containing protein.	Tyrosine-protein kinase.	0.666
A0A1L8EKH9	ifih1	A0A1L8EKH9	A0A1L8EW28	STAT_int domain-containing protein.	Uncharacterized protein.	0.452
A0A1L8EKH9	lep	A0A1L8EKH9	A0A1L8GZQ3	STAT_int domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.529
A0A1L8EKH9	lep-2	A0A1L8EKH9	Q563I5	STAT_int domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.529
A0A1L8EKH9	syk	A0A1L8EKH9	A0A1L8HYI7	STAT_int domain-containing protein.	Tyrosine-protein kinase.	0.666
A0A1L8EZY9	A0A1L8H564	A0A1L8EZY9	A0A1L8H564	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	BPTI/Kunitz inhibitor domain-containing protein.	0.933
A0A1L8EZY9	App.L	A0A1L8EZY9	A0A1L8HCN6	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	BPTI/Kunitz inhibitor domain-containing protein.	0.964
A0A1L8EZY9	psen1	A0A1L8EZY9	A0A1L8FAH5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.900
A0A1L8F0R1	tlr9	A0A1L8F0R1	A0A1L8GPC9	C-type lectin domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.490
A0A1L8FHP3	A0A1L8FTB8	A0A1L8FHP3	A0A1L8FTB8	TIR domain-containing protein.	ML domain-containing protein.	0.436
A0A1L8FHP3	A0A1L8HTX4	A0A1L8FHP3	A0A1L8HTX4	TIR domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.601
A0A1L8FHP3	Myd88.S	A0A1L8FHP3	A0A1L8FQF6	TIR domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.784
A0A1L8FHP3	myd88	A0A1L8FHP3	A0A1L8FV26	TIR domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.784
A0A1L8FHP3	tlr9	A0A1L8FHP3	A0A1L8GPC9	TIR domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.506