(98 nodes) Multicellular organism growth network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	stk40	Protein kinase domain-containing protein. (443 aa)
	Pkdcc2	Protein kinase domain containing, cytoplasmic 2. (480 aa)
	A0A1L8EKM7	Uncharacterized protein. (464 aa)
	Sp2.S	Uncharacterized protein. (560 aa)
	en1	Homeobox protein engrailed-like. (228 aa)
	A0A1L8EP59	Anion exchange protein. (812 aa)
	Scnn1b.S	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
	A0A1L8EQR1	PALB2_WD40 domain-containing protein. (1345 aa)
	A0A1L8EQU8	Uncharacterized protein. (1691 aa)
	Rara.L	Uncharacterized protein. (461 aa)
	sp2	Uncharacterized protein. (559 aa)
	Slc4a10.L	Anion exchange protein. (1087 aa)
	palb2	PALB2_WD40 domain-containing protein. (1427 aa)
	Scnn1b.L	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (647 aa)
	A0A1L8EYE3	Uncharacterized protein. (2027 aa)
	Pkdcc.1.S	Protein kinase domain-containing protein. (470 aa)
	A0A1L8F2G2	PHD-type domain-containing protein. (1187 aa)
	atrx	Uncharacterized protein. (2276 aa)
	ercc2	Helicase ATP-binding domain-containing protein. (736 aa)
	ttc8	TPR_REGION domain-containing protein. (505 aa)
	unc79	Uncharacterized protein. (2618 aa)
	Eylp01	Protein kinase domain-containing protein. (462 aa)
	tnks2	Poly [ADP-ribose] polymerase. (1165 aa)
	A0A1L8FGQ0	BZIP domain-containing protein. (308 aa)
	wdr11	WD_REPEATS_REGION domain-containing protein. (1214 aa)
	ercc1	Uncharacterized protein. (297 aa)
	ercc6	Uncharacterized protein. (1370 aa)
	A0A1L8FKW5	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2533 aa)
	A0A1L8FMS5	BZIP domain-containing protein. (308 aa)
	A0A1L8FNJ4	Amino acid transporter. (557 aa)
	A0A1L8FQC3	PID domain-containing protein. (462 aa)
	A0A1L8FQI2	Uncharacterized protein. (76 aa)
	Xrcc2.S	RECA_2 domain-containing protein. (223 aa)
	hoxa5	Homeobox domain-containing protein. (272 aa)
	A0A1L8FRE1	Uncharacterized protein. (447 aa)
	ankrd12	ANK_REP_REGION domain-containing protein. (1985 aa)
	A0A1L8FUT6	PID domain-containing protein. (409 aa)
	A0A1L8FV52	RECA_2 domain-containing protein. (213 aa)
	hoxa5-2	Homeobox domain-containing protein. (273 aa)
	A0A1L8FW99	Uncharacterized protein. (52 aa)
	A0A1L8FWE1	Uncharacterized protein. (395 aa)
	ankrd12-2	ANK_REP_REGION domain-containing protein. (1961 aa)
	Pkdcc1	Protein kinase domain-containing protein. (535 aa)
	sos1	Uncharacterized protein. (1325 aa)
	sos1-2	Uncharacterized protein. (1325 aa)
	Slc1a2.S	Amino acid transporter. (503 aa)
	A0A1L8GEM2	Uncharacterized protein. (659 aa)
	ankrd11	ANK_REP_REGION domain-containing protein. (2741 aa)
	A0A1L8GFU1	Uncharacterized protein. (636 aa)
	ep300	Uncharacterized protein. (2495 aa)
	slc1a2	Amino acid transporter. (568 aa)
	Stil.L	Uncharacterized protein. (1281 aa)
	ep300-2	Uncharacterized protein. (2492 aa)
	A0A1L8GSN7	TPR_REGION domain-containing protein. (282 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	A0A1L8H0S4	Peptidylprolyl isomerase. (452 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	A0A1L8H4Q1	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa)
	Kdm6a.S	Uncharacterized protein. (1455 aa)
	Stk40.S	Protein kinase domain-containing protein. (499 aa)
	A0A1L8H827	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (441 aa)
	slitrk1	Uncharacterized protein. (696 aa)
	Slitrk6.S	Uncharacterized protein. (799 aa)
	Rarg.S	Uncharacterized protein. (442 aa)
	A0A1L8HA90	Uncharacterized protein. (1906 aa)
	A0A1L8HAC0	Uncharacterized protein. (121 aa)
	wdtc1	Uncharacterized protein. (671 aa)
	A0A1L8HFB9	Uncharacterized protein. (1387 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
	slitrk1-2	Uncharacterized protein. (695 aa)
	slitrk6	Uncharacterized protein. (825 aa)
	A0A1L8HII8	Uncharacterized protein. (130 aa)
	A0A1L8HIJ2	Uncharacterized protein. (442 aa)
	A0A1L8HIK2	Uncharacterized protein. (1874 aa)
	fkbp8	Peptidylprolyl isomerase. (383 aa)
	A0A1L8HNZ8	BHLH domain-containing protein. (115 aa)
	apba1	Uncharacterized protein. (826 aa)
	A0A1L8HPD7	Uncharacterized protein. (341 aa)
	A0A1L8HPT4	Sep15_SelM domain-containing protein. (121 aa)
	tmed2	GOLD domain-containing protein. (201 aa)
	A0A1L8HRF5	Uncharacterized protein. (426 aa)
	helt	Uncharacterized protein. (252 aa)
	A0A1L8HXZ2	BHLH domain-containing protein. (115 aa)
	apba1-2	Uncharacterized protein. (820 aa)
	A0A1L8HYF4	DUF1767 domain-containing protein. (512 aa)
	A0A1L8HZS4	Sep15_SelM domain-containing protein. (124 aa)
	A0A1L8I318	Uncharacterized protein. (173 aa)
	Taf10.L	Uncharacterized protein. (107 aa)
	Ccdc151.L	Uncharacterized protein. (600 aa)
	fkbp8-2	Peptidylprolyl isomerase. (408 aa)
	en1-2	Homeobox protein engrailed-like. (229 aa)
	smpd3	MGC115457 protein. (659 aa)
	atf5.2	Atf5-prov protein. (308 aa)
	clic4	MGC83873 protein. (252 aa)
	clic4-2	CLIC4 protein. (252 aa)
	wdtc1-2	MGC68614 protein. (668 aa)
	tmed2-2	Rnp24-prov protein. (201 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EQR1	A0A1L8FQI2	A0A1L8EQR1	A0A1L8FQI2	PALB2_WD40 domain-containing protein.	Uncharacterized protein.	0.567
A0A1L8EQR1	A0A1L8FV52	A0A1L8EQR1	A0A1L8FV52	PALB2_WD40 domain-containing protein.	RECA_2 domain-containing protein.	0.567
A0A1L8EQR1	A0A1L8HFB9	A0A1L8EQR1	A0A1L8HFB9	PALB2_WD40 domain-containing protein.	Uncharacterized protein.	0.406
A0A1L8EQR1	A0A1L8HPD7	A0A1L8EQR1	A0A1L8HPD7	PALB2_WD40 domain-containing protein.	Uncharacterized protein.	0.536
A0A1L8EQR1	A0A1L8HRF5	A0A1L8EQR1	A0A1L8HRF5	PALB2_WD40 domain-containing protein.	Uncharacterized protein.	0.455
A0A1L8EQR1	A0A1L8HYF4	A0A1L8EQR1	A0A1L8HYF4	PALB2_WD40 domain-containing protein.	DUF1767 domain-containing protein.	0.536
A0A1L8EQR1	Kdm6a.S	A0A1L8EQR1	A0A1L8H6C8	PALB2_WD40 domain-containing protein.	Uncharacterized protein.	0.454
A0A1L8EQR1	Xrcc2.S	A0A1L8EQR1	A0A1L8FQL1	PALB2_WD40 domain-containing protein.	RECA_2 domain-containing protein.	0.567
A0A1L8EQR1	ankrd11	A0A1L8EQR1	A0A1L8GEN1	PALB2_WD40 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.455
A0A1L8EQR1	ankrd12	A0A1L8EQR1	A0A1L8FSP2	PALB2_WD40 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.455
A0A1L8EQR1	ankrd12-2	A0A1L8EQR1	A0A1L8FYG8	PALB2_WD40 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.455
A0A1L8EQR1	ercc2	A0A1L8EQR1	A0A1L8F8A3	PALB2_WD40 domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.401
A0A1L8EQR1	palb2	A0A1L8EQR1	A0A1L8EY82	PALB2_WD40 domain-containing protein.	PALB2_WD40 domain-containing protein.	0.900
A0A1L8EQU8	A0A1L8H4Q1	A0A1L8EQU8	A0A1L8H4Q1	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.549
A0A1L8EQU8	Tp53.L	A0A1L8EQU8	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.549
A0A1L8EYE3	A0A1L8H4Q1	A0A1L8EYE3	A0A1L8H4Q1	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.549
A0A1L8EYE3	Tp53.L	A0A1L8EYE3	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.549
A0A1L8F2G2	A0A1L8H4Q1	A0A1L8F2G2	A0A1L8H4Q1	PHD-type domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.598
A0A1L8F2G2	Tp53.L	A0A1L8F2G2	A0A1L8H4M6	PHD-type domain-containing protein.	P53 domain-containing protein.	0.598
A0A1L8FKW5	A0A1L8GSN7	A0A1L8FKW5	A0A1L8GSN7	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	TPR_REGION domain-containing protein.	0.578