(105 nodes) Endocrine system development network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8EKS1	Homeobox domain-containing protein. (388 aa)
	A0A1L8EPE6	Homeobox domain-containing protein. (412 aa)
	A0A1L8ES19	Homeobox domain-containing protein. (395 aa)
	hoxd3	Homeobox domain-containing protein. (412 aa)
	A0A1L8EX51	Uncharacterized protein. (327 aa)
	armc5	BTB domain-containing protein. (934 aa)
	A0A1L8F0V0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (650 aa)
	A0A1L8F518	Fibronectin type-III domain-containing protein. (433 aa)
	A0A1L8FD41	Uncharacterized protein. (428 aa)
	nkx6-2	Homeobox domain-containing protein. (281 aa)
	A0A1L8FEK1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
	Drd2.S	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	Pax10a	Homeobox domain-containing protein. (281 aa)
	A0A1L8FH29	Uncharacterized protein. (280 aa)
	A0A1L8FJ20	Homeobox domain-containing protein. (259 aa)
	Drd2.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (438 aa)
	mnx1	Homeobox domain-containing protein. (339 aa)
	hoxa5	Homeobox domain-containing protein. (272 aa)
	Tgfbr1.S	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (454 aa)
	slc6a3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
	Bmp6.S	TGF_BETA_2 domain-containing protein. (448 aa)
	gata6	Uncharacterized protein. (502 aa)
	hoxa5-2	Homeobox domain-containing protein. (273 aa)
	A0A1L8FW45	Homeobox domain-containing protein. (405 aa)
	A0A1L8FX26	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (487 aa)
	bmp6	TGF_BETA_2 domain-containing protein. (448 aa)
	Gcm2.L	GCM domain-containing protein. (555 aa)
	A0A1L8FYS5	GATA-type domain-containing protein. (466 aa)
	A0A1L8G058	Uncharacterized protein. (2287 aa)
	srf	MADS-box domain-containing protein. (449 aa)
	nkx2-2	Homeobox domain-containing protein. (271 aa)
	Pax1.S	Paired domain-containing protein. (449 aa)
	cyp1b1	Uncharacterized protein; Belongs to the cytochrome P450 family. (553 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	A0A1L8G3D5	NR LBD domain-containing protein. (268 aa)
	A0A1L8G623	Homeobox domain-containing protein. (242 aa)
	nkx2-2-2	Homeobox domain-containing protein. (271 aa)
	srf-2	MADS-box domain-containing protein. (448 aa)
	A0A1L8G7G5	Paired domain-containing protein. (437 aa)
	cyp1b1-2	Uncharacterized protein; Belongs to the cytochrome P450 family. (552 aa)
	Rfx6.L	RFX-type winged-helix domain-containing protein. (937 aa)
	A0A1L8GDD9	Uncharacterized protein. (414 aa)
	mdk	Uncharacterized protein. (142 aa)
	pax6	Uncharacterized protein. (467 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	A0A1L8GIG9	Dickkopf_N domain-containing protein. (407 aa)
	Mdk.L	Uncharacterized protein. (173 aa)
	pax6-2	Uncharacterized protein. (467 aa)
	A0A1L8GJ35	Uncharacterized protein. (380 aa)
	braf	Uncharacterized protein. (802 aa)
	pax8	Paired domain-containing protein. (467 aa)
	stra6	Uncharacterized protein. (639 aa)
	A0A1L8GTF9	Uncharacterized protein. (645 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	A0A1L8GXP7	Uncharacterized protein. (147 aa)
	nkx2-5	Homeobox domain-containing protein. (300 aa)
	Gata3.L	Uncharacterized protein. (454 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	A0A1L8GZR4	Uncharacterized protein. (318 aa)
	A0A1L8GZU0	Uncharacterized protein. (509 aa)
	stra6-2	Uncharacterized protein. (639 aa)
	pax8-2	Paired domain-containing protein. (465 aa)
	nr0b1	NR LBD domain-containing protein. (280 aa)
	Nf1.S	Uncharacterized protein. (2774 aa)
	gli1	Uncharacterized protein. (1361 aa)
	gsx1	Homeobox domain-containing protein. (235 aa)
	Pdx1.S	Homeobox domain-containing protein. (271 aa)
	nr0b1-2	NR LBD domain-containing protein. (280 aa)
	nf1	Uncharacterized protein. (2759 aa)
	Gli1.L	Uncharacterized protein. (1362 aa)
	gsx1-2	Homeobox domain-containing protein. (242 aa)
	pdx1	Homeobox domain-containing protein. (271 aa)
	eif2ak3	Protein kinase domain-containing protein. (1091 aa)
	anxa1.2	Annexin. (338 aa)
	pcsk1	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (741 aa)
	otp	Uncharacterized protein. (321 aa)
	A0A1L8HT45	Protein kinase domain-containing protein. (1127 aa)
	A0A1L8HY95	Annexin. (338 aa)
	A0A1L8HYC9	Annexin. (242 aa)
	A0A1L8I1P1	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (832 aa)
	otp-2	Uncharacterized protein. (320 aa)
	A0A310U4L0	Uncharacterized protein. (112 aa)
	gip	Glucose-dependent insulinotropic polypeptide. (150 aa)
	ednra	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	nkx6-1	NK6 transcription factor related locus 1. (351 aa)
	nog	Noggin; Belongs to the noggin family. (222 aa)
	H6D7E8_XENLA	Cytochrome P450 CYP1C; Belongs to the cytochrome P450 family. (522 aa)
	X-Delta-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
	edn1	LOC100158354 protein. (221 aa)
	gata3	XGATA-3 protein. (435 aa)
	mnx1-2	Hlxb9 protein. (333 aa)
	crkl	MGC84382 protein. (302 aa)
	anxa1.3	Annexin. (363 aa)
	anxa1.1	Annexin. (343 aa)
	crkl-2	MGC81407 protein. (302 aa)
	hnf1b	MGC68543 protein. (561 aa)
	anxa1.1-2	Annexin. (343 aa)
	nkx2-5-2	Nkx2.5 protein. (299 aa)
	hnf1b-2	Tcf2 protein. (561 aa)
	ednra-2	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	hoxa3	Hoxa3a-prov protein. (406 aa)
	creb1	Creb1-prov protein. (324 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	dll1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
	Pax10b	Paired box 10b. (281 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EX51	srf	A0A1L8EX51	A0A1L8G0Z2	Uncharacterized protein.	MADS-box domain-containing protein.	0.489
A0A1L8EX51	srf-2	A0A1L8EX51	A0A1L8G721	Uncharacterized protein.	MADS-box domain-containing protein.	0.489
A0A1L8F518	A0A1L8FD41	A0A1L8F518	A0A1L8FD41	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.901
A0A1L8FD41	A0A1L8F518	A0A1L8FD41	A0A1L8F518	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.901
A0A1L8FEK1	edn1	A0A1L8FEK1	Q08B43	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LOC100158354 protein.	0.475
A0A1L8FW45	hoxa5	A0A1L8FW45	A0A1L8FR89	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.669
A0A1L8FW45	hoxa5-2	A0A1L8FW45	A0A1L8FW27	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.669
A0A1L8FX26	Tgfbr1.S	A0A1L8FX26	A0A1L8FRZ0	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.900
A0A1L8FYS5	A0A1L8GXP7	A0A1L8FYS5	A0A1L8GXP7	GATA-type domain-containing protein.	Uncharacterized protein.	0.648
A0A1L8FYS5	nkx2-5	A0A1L8FYS5	A0A1L8GXU4	GATA-type domain-containing protein.	Homeobox domain-containing protein.	0.648
A0A1L8FYS5	nkx2-5-2	A0A1L8FYS5	Q7T0T3	GATA-type domain-containing protein.	Nkx2.5 protein.	0.648
A0A1L8G058	braf	A0A1L8G058	A0A1L8GQP3	Uncharacterized protein.	Uncharacterized protein.	0.536
A0A1L8G058	pax8	A0A1L8G058	A0A1L8GS54	Uncharacterized protein.	Paired domain-containing protein.	0.792
A0A1L8G058	pax8-2	A0A1L8G058	A0A1L8H1M7	Uncharacterized protein.	Paired domain-containing protein.	0.791
A0A1L8G3D5	A0A1L8GDD9	A0A1L8G3D5	A0A1L8GDD9	NR LBD domain-containing protein.	Uncharacterized protein.	0.402
A0A1L8G3D5	A0A1L8GJ35	A0A1L8G3D5	A0A1L8GJ35	NR LBD domain-containing protein.	Uncharacterized protein.	0.402
A0A1L8GDD9	A0A1L8G3D5	A0A1L8GDD9	A0A1L8G3D5	Uncharacterized protein.	NR LBD domain-containing protein.	0.402
A0A1L8GDD9	nr0b1	A0A1L8GDD9	A0A1L8H4N5	Uncharacterized protein.	NR LBD domain-containing protein.	0.402
A0A1L8GDD9	nr0b1-2	A0A1L8GDD9	A0A1L8HDG1	Uncharacterized protein.	NR LBD domain-containing protein.	0.402
A0A1L8GJ35	A0A1L8G3D5	A0A1L8GJ35	A0A1L8G3D5	Uncharacterized protein.	NR LBD domain-containing protein.	0.402