(78 nodes) Cellular response to glucose starvation network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nuak2-2	LOC495481 protein. (570 aa)
	A0A1L8ENS9	Uncharacterized protein. (305 aa)
	Nfe2l2.S	BZIP domain-containing protein; Belongs to the bZIP family. (590 aa)
	bhlha15	BHLH domain-containing protein. (175 aa)
	Prkag3-b	Uncharacterized protein. (340 aa)
	bhlha15-2	BHLH domain-containing protein. (175 aa)
	hspa5	Uncharacterized protein; Belongs to the heat shock protein 70 family. (658 aa)
	Kptn.L	Uncharacterized protein. (481 aa)
	atg14	Uncharacterized protein. (514 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (722 aa)
	sik2	Uncharacterized protein. (896 aa)
	A0A1L8FH79	Uncharacterized protein. (619 aa)
	Sirt1.L	Deacetylase sirtuin-type domain-containing protein. (722 aa)
	sik2-2	Uncharacterized protein. (901 aa)
	A0A1L8FNM3	Protein kinase domain-containing protein. (837 aa)
	Prkag1.S	Uncharacterized protein. (521 aa)
	pik3r4	Uncharacterized protein. (1363 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	A0A1L8FV68	Uncharacterized protein. (519 aa)
	pik3r4-2	Uncharacterized protein. (1363 aa)
	upp1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (311 aa)
	A0A1L8FXP7	BH4_2 domain-containing protein. (300 aa)
	Impact.L	RWD domain-containing protein. (314 aa)
	A0A1L8G2R0	Uncharacterized protein. (110 aa)
	Sesn1.S	Uncharacterized protein. (481 aa)
	sesn1	Uncharacterized protein. (481 aa)
	A0A1L8G9G9	Uncharacterized protein. (111 aa)
	A0A1L8GDS0	Protein kinase domain-containing protein. (1019 aa)
	A0A1L8GFI4	Non-specific serine/threonine protein kinase. (551 aa)
	Atf4.S	BZIP domain-containing protein. (342 aa)
	A0A1L8GHI4	Uncharacterized protein. (405 aa)
	A0A1L8GHT5	Protein kinase domain-containing protein. (598 aa)
	A0A1L8GJ81	Protein kinase domain-containing protein. (707 aa)
	A0A1L8GM16	Non-specific serine/threonine protein kinase. (551 aa)
	A0A1L8GM41	Uncharacterized protein. (3539 aa)
	Atf4.L	BZIP domain-containing protein. (343 aa)
	A0A1L8GPV5	Protein kinase domain-containing protein. (603 aa)
	C12orf66.S	Uncharacterized protein. (478 aa)
	nuak1	Protein kinase domain-containing protein. (659 aa)
	itfg2	Uncharacterized protein. (444 aa)
	nuak1-2	Protein kinase domain-containing protein. (661 aa)
	C12orf66.L	Uncharacterized protein. (477 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	A0A1L8H4Q1	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa)
	tbl2	WD_REPEATS_REGION domain-containing protein. (436 aa)
	sik1	Protein kinase domain-containing protein. (637 aa)
	A0A1L8H7F6	Uncharacterized protein. (449 aa)
	zc3h12a	C3H1-type domain-containing protein. (637 aa)
	A0A1L8H9N3	Uncharacterized protein. (371 aa)
	sesn3	Uncharacterized protein. (484 aa)
	rrp8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (480 aa)
	Tbl2.L	WD_REPEATS_REGION domain-containing protein. (436 aa)
	nuak2	Protein kinase domain-containing protein. (570 aa)
	zc3h12a-2	C3H1-type domain-containing protein. (644 aa)
	mybbp1a	Uncharacterized protein. (1290 aa)
	Prkag2.L	Uncharacterized protein. (346 aa)
	rrp8-2	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (467 aa)
	eif2ak3	Protein kinase domain-containing protein. (1091 aa)
	mtmr3	Uncharacterized protein. (1209 aa)
	A0A1L8HPZ2	Uncharacterized protein. (1011 aa)
	A0A1L8HQW3	BZIP domain-containing protein. (433 aa)
	nim1k	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
	A0A1L8HS44	Phosphatidylinositol 3-kinase catalytic subunit type 3. (847 aa)
	A0A1L8HT45	Protein kinase domain-containing protein. (1127 aa)
	Mtmr3	Uncharacterized protein. (1224 aa)
	A0A1L8I199	BZIP domain-containing protein. (390 aa)
	nim1k-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	pick1	MGC131295 protein. (405 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (560 aa)
	nfe2l2	MGC53355 protein. (591 aa)
	plin2	Perilipin; Belongs to the perilipin family. (404 aa)
	sesn3-2	MGC80167 protein. (480 aa)
	plin2-2	Perilipin; Belongs to the perilipin family. (428 aa)
	sesn2	MGC81239 protein. (413 aa)
	slc7a5	MGC68975 protein. (507 aa)
	hspa5-2	Hspa5 protein; Belongs to the heat shock protein 70 family. (655 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (560 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENS9	A0A1L8GFI4	A0A1L8ENS9	A0A1L8GFI4	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.825
A0A1L8ENS9	A0A1L8GM16	A0A1L8ENS9	A0A1L8GM16	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.825
A0A1L8ENS9	A0A1L8H7F6	A0A1L8ENS9	A0A1L8H7F6	Uncharacterized protein.	Uncharacterized protein.	0.411
A0A1L8ENS9	A0A1L8HS44	A0A1L8ENS9	A0A1L8HS44	Uncharacterized protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.567
A0A1L8ENS9	nim1k	A0A1L8ENS9	A0A1L8HRQ1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.587
A0A1L8ENS9	nim1k-2	A0A1L8ENS9	A0A1L8I2G5	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.587
A0A1L8ENS9	pik3c3	A0A1L8ENS9	A0A1L8I323	Uncharacterized protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.567
A0A1L8ENS9	pik3r4	A0A1L8ENS9	A0A1L8FRJ7	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENS9	pik3r4-2	A0A1L8ENS9	A0A1L8FWE8	Uncharacterized protein.	Uncharacterized protein.	0.558
A0A1L8ENS9	prkaa1	A0A1L8ENS9	Q5U5E3	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.843
A0A1L8ENS9	prkaa2	A0A1L8ENS9	Q8UVW8	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.843
A0A1L8ENS9	sesn2	A0A1L8ENS9	Q6NU55	Uncharacterized protein.	MGC81239 protein.	0.411
A0A1L8FV68	A0A1L8GFI4	A0A1L8FV68	A0A1L8GFI4	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.825
A0A1L8FV68	A0A1L8GM16	A0A1L8FV68	A0A1L8GM16	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.825
A0A1L8FV68	A0A1L8H7F6	A0A1L8FV68	A0A1L8H7F6	Uncharacterized protein.	Uncharacterized protein.	0.411
A0A1L8FV68	A0A1L8HS44	A0A1L8FV68	A0A1L8HS44	Uncharacterized protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.567
A0A1L8FV68	nim1k	A0A1L8FV68	A0A1L8HRQ1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.587
A0A1L8FV68	nim1k-2	A0A1L8FV68	A0A1L8I2G5	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.587
A0A1L8FV68	pik3c3	A0A1L8FV68	A0A1L8I323	Uncharacterized protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.567
A0A1L8FV68	pik3r4	A0A1L8FV68	A0A1L8FRJ7	Uncharacterized protein.	Uncharacterized protein.	0.558