(44 nodes) Positive regulation of JUN kinase activity network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8FSE2	TNFR-Cys domain-containing protein. (579 aa)
	ern1	Uncharacterized protein. (990 aa)
	Dusp19.S	Uncharacterized protein. (132 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (961 aa)
	fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	Ern2.S	Uncharacterized protein. (958 aa)
	ern1-2	Uncharacterized protein. (969 aa)
	Dusp19.L	Uncharacterized protein. (216 aa)
	Map3k13.L	Mitogen-activated protein kinase kinase kinase. (961 aa)
	A0A1L8EX74	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
	ern2	Uncharacterized protein. (957 aa)
	tnf	TNF_2 domain-containing protein. (227 aa)
	A0A1L8FDP4	Uncharacterized protein. (1758 aa)
	A0A1L8FHG0	Uncharacterized protein. (581 aa)
	A0A1L8FI35	DH domain-containing protein. (1852 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	ptpn1	Tyrosine-protein phosphatase non-receptor type. (430 aa)
	Traf6.L	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	A0A1L8GRE9	Protein kinase domain-containing protein. (455 aa)
	Map2k7.S	Protein kinase domain-containing protein. (489 aa)
	map3k12	Mitogen-activated protein kinase kinase kinase. (807 aa)
	Fzd4.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
	map3k12-2	Mitogen-activated protein kinase kinase kinase. (808 aa)
	A0A1L8HJF4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (456 aa)
	rps3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)
	ror2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	A0A1L8HS54	SCY domain-containing protein. (97 aa)
	syk	Tyrosine-protein kinase. (605 aa)
	tnf-2	Tumor necrosis factor alpha. (225 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	map3k7	MAP3K7 protein. (616 aa)
	edn1	LOC100158354 protein. (221 aa)
	ptpn1-2	Tyrosine-protein phosphatase non-receptor type. (428 aa)
	rpls3-b	Rpls3-b protein; Belongs to the universal ribosomal protein uS3 family. (246 aa)
	ror2-2	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (930 aa)
	Syk.S	Tyrosine-protein kinase. (632 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	A0A1L8FXM9	TNFR-Cys domain-containing protein. (573 aa)
	A0A1L8G2A9	Uncharacterized protein. (214 aa)
	A0A1L8G2F3	Protein kinase domain-containing protein. (1486 aa)
	Sash1.S	Uncharacterized protein. (954 aa)
	A0A1L8G366	Protein kinase domain-containing protein. (588 aa)
	Traf6.S	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EX74	ror2	A0A1L8EX74	A0A1L8HPI6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.790
A0A1L8EX74	ror2-2	A0A1L8EX74	Q8AV69	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase Xror2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.790
A0A1L8FSE2	A0A1L8FXM9	A0A1L8FSE2	A0A1L8FXM9	TNFR-Cys domain-containing protein.	TNFR-Cys domain-containing protein.	0.901
A0A1L8FSE2	Traf6.L	A0A1L8FSE2	A0A1L8GIM0	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
A0A1L8FSE2	Traf6.S	A0A1L8FSE2	A0A1L8GE35	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
A0A1L8FXM9	A0A1L8FSE2	A0A1L8FXM9	A0A1L8FSE2	TNFR-Cys domain-containing protein.	TNFR-Cys domain-containing protein.	0.901
A0A1L8FXM9	Traf6.L	A0A1L8FXM9	A0A1L8GIM0	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
A0A1L8FXM9	Traf6.S	A0A1L8FXM9	A0A1L8GE35	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
A0A1L8G366	A0A1L8GRE9	A0A1L8G366	A0A1L8GRE9	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.727
A0A1L8G366	Map2k7.S	A0A1L8G366	A0A1L8H2J9	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.727
A0A1L8G366	Traf6.L	A0A1L8G366	A0A1L8GIM0	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.981
A0A1L8G366	Traf6.S	A0A1L8G366	A0A1L8GE35	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.981
A0A1L8GRE9	A0A1L8G366	A0A1L8GRE9	A0A1L8G366	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.727
A0A1L8GRE9	Dusp19.L	A0A1L8GRE9	A0A1L8EWN0	Protein kinase domain-containing protein.	Uncharacterized protein.	0.528
A0A1L8GRE9	Dusp19.S	A0A1L8GRE9	A0A1L8EPF4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.528
A0A1L8GRE9	Map2k7.S	A0A1L8GRE9	A0A1L8H2J9	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.900
A0A1L8GRE9	Map3k13.L	A0A1L8GRE9	A0A1L8EWY9	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase.	0.928
A0A1L8GRE9	Syk.S	A0A1L8GRE9	A0A1L8HPI7	Protein kinase domain-containing protein.	Tyrosine-protein kinase.	0.408
A0A1L8GRE9	Traf6.L	A0A1L8GRE9	A0A1L8GIM0	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.448
A0A1L8GRE9	Traf6.S	A0A1L8GRE9	A0A1L8GE35	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.448