83 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Dtl.L	WD_REPEATS_REGION domain-containing protein. (711 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	sde2-2	Sde2_N_Ubi domain-containing protein. (447 aa)
	Bre.L	Uncharacterized protein. (404 aa)
	A0A1L8GDE6	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (286 aa)
	rfwd3	RING-type domain-containing protein. (750 aa)
	pidd1	Uncharacterized protein. (909 aa)
	mus81	ERCC4 domain-containing protein. (613 aa)
	Fbxo31.L	F-box domain-containing protein. (523 aa)
	rfwd3-2	RING-type domain-containing protein. (751 aa)
	fancd2	Uncharacterized protein. (1445 aa)
	xpc	Uncharacterized protein. (1062 aa)
	blm	Uncharacterized protein. (1368 aa)
	Tipin.S	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
	ticrr	Treslin_N domain-containing protein. (1968 aa)
	A0A1L8GY09	RAP80_UIM domain-containing protein. (937 aa)
	Gtse1.L	GTSE1_N domain-containing protein. (724 aa)
	Ticrr.L	Treslin_N domain-containing protein. (1985 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	cradd.2	MGC78788 protein. (197 aa)
	Clspn.S	Claspin. (1286 aa)
	rint1	LOC100174798 protein. (785 aa)
	MGC81311	Protein kinase domain-containing protein. (1001 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	A0A1L8I1K3	Uncharacterized protein. (275 aa)
	rad9b	Cell cycle checkpoint control protein; Belongs to the rad9 family. (483 aa)
	Taok3.L	Protein kinase domain-containing protein. (911 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	A0A1L8I081	Uncharacterized protein. (96 aa)
	babam1	Uncharacterized protein. (328 aa)
	A0A1L8HVY7	Uncharacterized protein. (326 aa)
	A0A1L8HVW6	WD_REPEATS_REGION domain-containing protein. (218 aa)
	Fzr1.L	WD_REPEATS_REGION domain-containing protein. (251 aa)
	A0A1L8HRA7	Uncharacterized protein. (177 aa)
	A0A1L8HQX5	Protein kinase domain-containing protein. (905 aa)
	abraxas1	MPN domain-containing protein. (408 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (711 aa)
	A0A1L8H1D5	Uncharacterized protein. (1367 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	A0A1L8H4Q1	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa)
	A0A1L8HF97	Uncharacterized protein. (489 aa)
	donson	Uncharacterized protein. (579 aa)
	taok1	Protein kinase domain-containing protein. (1001 aa)
	Cdk5rap3.S	Uncharacterized protein. (505 aa)
	mfsd11	Uncharacterized protein. (445 aa)
	cdca7	zf-4CXXC_R1 domain-containing protein. (431 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	Cdk5rap3.L	Uncharacterized protein. (532 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	Eme1.L	ERCC4 domain-containing protein. (411 aa)
	A0A1L8EUJ5	Uncharacterized protein. (445 aa)
	eme2	ERCC4 domain-containing protein. (500 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	A0A1L8F0I0	Fork-head domain-containing protein. (462 aa)
	foxo4	Fork-head domain-containing protein. (492 aa)
	muc1	SEA domain-containing protein. (692 aa)
	brcc3	MPN domain-containing protein. (261 aa)
	Foxo4.L	Fork-head domain-containing protein. (485 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (452 aa)
	foxn3	Fork-head domain-containing protein. (487 aa)
	A0A1L8FDU4	Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	Casp2.L	Uncharacterized protein; Belongs to the peptidase C14A family. (423 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	A0A1L8FPV0	Uncharacterized protein. (145 aa)
	wac	WW domain-containing protein. (631 aa)
	Syf2.S	Uncharacterized protein. (249 aa)
	znf830	Uncharacterized protein. (356 aa)
	wac-2	WW domain-containing protein. (652 aa)
	A0A1L8FVY6	Uncharacterized protein. (249 aa)
	A0A1L8FW69	Uncharacterized protein. (279 aa)
	nek11	Protein kinase domain-containing protein. (599 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	A0A1L8FXP8	Uncharacterized protein. (349 aa)
	Prkdc.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
	Nbn.L	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
	sde2	Sde2_N_Ubi domain-containing protein. (454 aa)
	dtl	WD_REPEATS_REGION domain-containing protein. (710 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FDU4	A0A1L8HF97	A0A1L8FDU4	A0A1L8HF97	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.462
A0A1L8FDU4	Casp2.L	A0A1L8FDU4	A0A1L8FIC4	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.901
A0A1L8FDU4	Cdk1.L	A0A1L8FDU4	A0A1L8FIT4	Uncharacterized protein; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.485
A0A1L8FDU4	Clspn.S	A0A1L8FDU4	F8WKR8	Uncharacterized protein; Belongs to the peptidase C14A family.	Claspin.	0.462
A0A1L8FDU4	Plk1.S	A0A1L8FDU4	A0A1L8EQN7	Uncharacterized protein; Belongs to the peptidase C14A family.	Serine/threonine-protein kinase PLK.	0.483
A0A1L8FDU4	Prkdc.L	A0A1L8FDU4	A0A1L8FYZ4	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.476
A0A1L8FDU4	Tp53.L	A0A1L8FDU4	A0A1L8H4M6	Uncharacterized protein; Belongs to the peptidase C14A family.	P53 domain-containing protein.	0.659
A0A1L8FDU4	cdk1	A0A1L8FDU4	A0A1L8FE96	Uncharacterized protein; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.485
A0A1L8FDU4	chek1	A0A1L8FDU4	A0A1L8FFS1	Uncharacterized protein; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.513
A0A1L8FDU4	chek1-2	A0A1L8FDU4	A0A1L8FL95	Uncharacterized protein; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein.	0.513
A0A1L8FDU4	cradd.2	A0A1L8FDU4	Q6GR68	Uncharacterized protein; Belongs to the peptidase C14A family.	MGC78788 protein.	0.996
A0A1L8FDU4	pidd1	A0A1L8FDU4	A0A1L8GJE2	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.989
A0A1L8FDU4	plk1	A0A1L8FDU4	A0A1L8EYC7	Uncharacterized protein; Belongs to the peptidase C14A family.	Serine/threonine-protein kinase PLK.	0.465
A0A1L8FPV0	A0A1L8I081	A0A1L8FPV0	A0A1L8I081	Uncharacterized protein.	Uncharacterized protein.	0.439
A0A1L8FPV0	Brca1.L	A0A1L8FPV0	A0A1L8ETS4	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A1L8FPV0	Bre.L	A0A1L8FPV0	A0A1L8G6S8	Uncharacterized protein.	Uncharacterized protein.	0.960
A0A1L8FPV0	Chek2.L	A0A1L8FPV0	A0A1L8I0A0	Uncharacterized protein.	Uncharacterized protein.	0.439
A0A1L8FPV0	Nbn.L	A0A1L8FPV0	A0A1L8FZE8	Uncharacterized protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.558
A0A1L8FPV0	babam1	A0A1L8FPV0	A0A1L8HXR8	Uncharacterized protein.	Uncharacterized protein.	0.959
A0A1L8FPV0	brcc3	A0A1L8FPV0	A0A1L8F6Q4	Uncharacterized protein.	MPN domain-containing protein.	0.960