61 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MGC81311	Protein kinase domain-containing protein. (1001 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	A0A1L8I1K3	Uncharacterized protein. (275 aa)
	Taok3.L	Protein kinase domain-containing protein. (911 aa)
	chfr	Uncharacterized protein. (625 aa)
	babam1	Uncharacterized protein. (328 aa)
	A0A1L8HVY7	Uncharacterized protein. (326 aa)
	A0A1L8HVW6	WD_REPEATS_REGION domain-containing protein. (218 aa)
	Fzr1.L	WD_REPEATS_REGION domain-containing protein. (251 aa)
	A0A1L8HRA7	Uncharacterized protein. (177 aa)
	A0A1L8HQX5	Protein kinase domain-containing protein. (905 aa)
	A0A1L8HQH5	Uncharacterized protein. (621 aa)
	abraxas1	MPN domain-containing protein. (408 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (711 aa)
	nabp2-2	OB domain-containing protein. (203 aa)
	A0A1L8HF97	Uncharacterized protein. (489 aa)
	donson	Uncharacterized protein. (579 aa)
	nabp2	OB domain-containing protein. (203 aa)
	taok1	Protein kinase domain-containing protein. (1001 aa)
	A0A1L8H1D5	Uncharacterized protein. (1367 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	A0A1L8FW69	Uncharacterized protein. (279 aa)
	A0A1L8FVY6	Uncharacterized protein. (249 aa)
	Xcdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
	Cdk5rap3.S	Uncharacterized protein. (505 aa)
	mfsd11	Uncharacterized protein. (445 aa)
	Plk1.S	Serine/threonine-protein kinase PLK. (598 aa)
	Cdc6.L	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (645 aa)
	Cdk5rap3.L	Uncharacterized protein. (532 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	A0A1L8EUJ5	Uncharacterized protein. (445 aa)
	plk1	Serine/threonine-protein kinase PLK. (598 aa)
	A0A1L8F0I0	Fork-head domain-containing protein. (462 aa)
	foxo4	Fork-head domain-containing protein. (492 aa)
	A0A1L8F537	Uncharacterized protein. (965 aa)
	brcc3	MPN domain-containing protein. (261 aa)
	Foxo4.L	Fork-head domain-containing protein. (485 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (452 aa)
	foxn3	Fork-head domain-containing protein. (487 aa)
	ints3	Uncharacterized protein. (1018 aa)
	cdk1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	Cdk1.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (333 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	A0A1L8FPV0	Uncharacterized protein. (145 aa)
	Syf2.S	Uncharacterized protein. (249 aa)
	znf830	Uncharacterized protein. (356 aa)
	ticrr	Treslin_N domain-containing protein. (1968 aa)
	blm	Uncharacterized protein. (1368 aa)
	Orc1.L	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (886 aa)
	Nae1.S	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
	Bre.L	Uncharacterized protein. (404 aa)
	Dtl.L	WD_REPEATS_REGION domain-containing protein. (711 aa)
	dtl	WD_REPEATS_REGION domain-containing protein. (710 aa)
	Nbn.L	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa)
	A0A1L8FXP8	Uncharacterized protein. (349 aa)
	Ticrr.L	Treslin_N domain-containing protein. (1985 aa)
	A0A1L8GY09	RAP80_UIM domain-containing protein. (937 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	Clspn.S	Claspin. (1286 aa)
	rint1	LOC100174798 protein. (785 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F537	nabp2	A0A1L8F537	A0A1L8H9L5	Uncharacterized protein.	OB domain-containing protein.	0.932
A0A1L8F537	nabp2-2	A0A1L8F537	A0A1L8HHU4	Uncharacterized protein.	OB domain-containing protein.	0.932
A0A1L8FPV0	Brca1.L	A0A1L8FPV0	A0A1L8ETS4	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A1L8FPV0	Bre.L	A0A1L8FPV0	A0A1L8G6S8	Uncharacterized protein.	Uncharacterized protein.	0.960
A0A1L8FPV0	Nbn.L	A0A1L8FPV0	A0A1L8FZE8	Uncharacterized protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.558
A0A1L8FPV0	babam1	A0A1L8FPV0	A0A1L8HXR8	Uncharacterized protein.	Uncharacterized protein.	0.959
A0A1L8FPV0	brcc3	A0A1L8FPV0	A0A1L8F6Q4	Uncharacterized protein.	MPN domain-containing protein.	0.960
A0A1L8FPV0	mre11	A0A1L8FPV0	A0A1L8HJD9	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.625
A0A1L8FVY6	Syf2.S	A0A1L8FVY6	A0A1L8FR32	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A1L8FVY6	Ticrr.L	A0A1L8FVY6	A0A1L8H0X3	Uncharacterized protein.	Treslin_N domain-containing protein.	0.577
A0A1L8FVY6	ticrr	A0A1L8FVY6	A0A1L8GSL4	Uncharacterized protein.	Treslin_N domain-containing protein.	0.577
A0A1L8FW69	Brca1.L	A0A1L8FW69	A0A1L8ETS4	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A1L8FW69	Bre.L	A0A1L8FW69	A0A1L8G6S8	Uncharacterized protein.	Uncharacterized protein.	0.960
A0A1L8FW69	Nbn.L	A0A1L8FW69	A0A1L8FZE8	Uncharacterized protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.558
A0A1L8FW69	babam1	A0A1L8FW69	A0A1L8HXR8	Uncharacterized protein.	Uncharacterized protein.	0.959
A0A1L8FW69	brcc3	A0A1L8FW69	A0A1L8F6Q4	Uncharacterized protein.	MPN domain-containing protein.	0.960
A0A1L8FW69	mre11	A0A1L8FW69	A0A1L8HJD9	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.625
A0A1L8FXP8	Brca1.L	A0A1L8FXP8	A0A1L8ETS4	Uncharacterized protein.	Uncharacterized protein.	0.917
A0A1L8FXP8	Bre.L	A0A1L8FXP8	A0A1L8G6S8	Uncharacterized protein.	Uncharacterized protein.	0.960
A0A1L8FXP8	Nbn.L	A0A1L8FXP8	A0A1L8FZE8	Uncharacterized protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.558