(40 nodes) Protein insertion into ER membrane network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	emc3	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
	tmem111-2	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (252 aa)
	wdr83os	MGC81480 protein. (106 aa)
	emc8-2	LOC495028 protein. (202 aa)
	tmem111	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (252 aa)
	emc9	MGC131176 protein. (206 aa)
	Ccdc47.S	Uncharacterized protein. (489 aa)
	get4	Uncharacterized protein. (325 aa)
	ccdc47	Uncharacterized protein. (488 aa)
	A0A1L8EXT9	Uncharacterized protein. (299 aa)
	emc6-2	LOC100137696 protein. (110 aa)
	A0A310U4M4	Uncharacterized protein. (241 aa)
	A0A310U421	Ubiquitin-like domain-containing protein. (93 aa)
	emc4	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (180 aa)
	Sgta.L	TPR_REGION domain-containing protein. (314 aa)
	A0A1L8HPQ4	Uncharacterized protein. (201 aa)
	A0A1L8HN54	TPR_REGION domain-containing protein. (280 aa)
	Wrb.L	Uncharacterized protein. (178 aa)
	A0A1L8H5D6	Uncharacterized protein. (170 aa)
	emc6	Uncharacterized protein. (110 aa)
	asna1	ATPase asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (342 aa)
	A0A1L8F1M8	Ubiquitin-like domain-containing protein. (148 aa)
	mmgt1	Uncharacterized protein. (132 aa)
	Bag6.S	Ubiquitin-like domain-containing protein. (1116 aa)
	emc7	DUF2012 domain-containing protein. (238 aa)
	mmgt1-2	Uncharacterized protein. (132 aa)
	bag6	Ubiquitin-like domain-containing protein. (1137 aa)
	emc7-2	DUF2012 domain-containing protein. (246 aa)
	emc10	Uncharacterized protein. (277 aa)
	emc1	EMC1_C domain-containing protein. (987 aa)
	Emc10.L	Uncharacterized protein. (267 aa)
	Emc1.L	EMC1_C domain-containing protein. (987 aa)
	A0A1L8FT88	Translocating chain-associated membrane protein; Belongs to the TRAM family. (379 aa)
	emc2	TPR_REGION domain-containing protein. (297 aa)
	emc2-2	TPR_REGION domain-containing protein. (297 aa)
	tram2	Translocating chain-associated membrane protein; Belongs to the TRAM family. (371 aa)
	Tram2.L	Translocating chain-associated membrane protein; Belongs to the TRAM family. (371 aa)
	emc8	MPN domain-containing protein. (202 aa)
	A0A1L8GLV2	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (249 aa)
	camlg	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (276 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EXT9	A0A1L8F1M8	A0A1L8EXT9	A0A1L8F1M8	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.812
A0A1L8EXT9	A0A1L8H5D6	A0A1L8EXT9	A0A1L8H5D6	Uncharacterized protein.	Uncharacterized protein.	0.617
A0A1L8EXT9	A0A1L8HN54	A0A1L8EXT9	A0A1L8HN54	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.854
A0A1L8EXT9	A0A310U421	A0A1L8EXT9	A0A310U421	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.812
A0A1L8EXT9	Bag6.S	A0A1L8EXT9	A0A1L8F3P1	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.961
A0A1L8EXT9	Sgta.L	A0A1L8EXT9	A0A1L8HWF0	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.854
A0A1L8EXT9	Wrb.L	A0A1L8EXT9	A0A1L8HCE0	Uncharacterized protein.	Uncharacterized protein.	0.617
A0A1L8EXT9	asna1	A0A1L8EXT9	A0A1L8H300	Uncharacterized protein.	ATPase asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.981
A0A1L8EXT9	bag6	A0A1L8EXT9	A0A1L8F8H4	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.961
A0A1L8EXT9	camlg	A0A1L8EXT9	A0A1L8GWV0	Uncharacterized protein.	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.	0.591
A0A1L8F1M8	A0A1L8EXT9	A0A1L8F1M8	A0A1L8EXT9	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.812
A0A1L8F1M8	A0A1L8H5D6	A0A1L8F1M8	A0A1L8H5D6	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.428
A0A1L8F1M8	A0A1L8HN54	A0A1L8F1M8	A0A1L8HN54	Ubiquitin-like domain-containing protein.	TPR_REGION domain-containing protein.	0.613
A0A1L8F1M8	Bag6.S	A0A1L8F1M8	A0A1L8F3P1	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.902
A0A1L8F1M8	Sgta.L	A0A1L8F1M8	A0A1L8HWF0	Ubiquitin-like domain-containing protein.	TPR_REGION domain-containing protein.	0.946
A0A1L8F1M8	Wrb.L	A0A1L8F1M8	A0A1L8HCE0	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.428
A0A1L8F1M8	asna1	A0A1L8F1M8	A0A1L8H300	Ubiquitin-like domain-containing protein.	ATPase asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.820
A0A1L8F1M8	bag6	A0A1L8F1M8	A0A1L8F8H4	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.902
A0A1L8F1M8	camlg	A0A1L8F1M8	A0A1L8GWV0	Ubiquitin-like domain-containing protein.	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.	0.503
A0A1L8F1M8	get4	A0A1L8F1M8	A0A1L8EQG4	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.812