(77 nodes) Negative regulation of innate immune response network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ythdf2.L	YTH domain-containing protein. (495 aa)
	Ythdf2.S	YTH domain-containing protein. (494 aa)
	A0A1L8H2R7	C-type lectin domain-containing protein. (182 aa)
	A0A1L8GYL7	Protein kinase domain-containing protein. (565 aa)
	ttll12	Uncharacterized protein. (636 aa)
	A0A1L8GKK8	NACHT domain-containing protein. (1832 aa)
	banf1-2	Uncharacterized protein. (90 aa)
	A0A1L8GJT0	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (424 aa)
	igf2-2	IlGF domain-containing protein. (217 aa)
	igf2	IlGF domain-containing protein. (217 aa)
	A0A1L8GCV6	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (423 aa)
	banf1	Uncharacterized protein. (90 aa)
	A0A1L8G9F4	Autophagy protein 5; Involved in autophagic vesicle formation. (334 aa)
	Baf-l.L	Uncharacterized protein. (112 aa)
	A0A1L8G6K2	Uncharacterized protein. (474 aa)
	A0A1L8G644	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
	Tnfaip3.S	Uncharacterized protein. (781 aa)
	A0A1L8G129	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa)
	A0A1L8G125	Uncharacterized protein. (474 aa)
	ythdf3	YTH domain-containing protein. (572 aa)
	A0A1L8FYE8	Tyrosine-protein phosphatase non-receptor type. (462 aa)
	A0A1L8FW08	DC_STAMP domain-containing protein. (651 aa)
	A0A1L8FVB1	DC_STAMP domain-containing protein. (719 aa)
	Ythdf3.S	YTH domain-containing protein. (572 aa)
	mul1	RING-type domain-containing protein. (353 aa)
	Drd2.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (438 aa)
	nlrx1	NACHT domain-containing protein. (953 aa)
	Drd2.S	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	A0A1L8FD24	Uncharacterized protein. (1045 aa)
	A0A1L8F749	Uncharacterized protein. (498 aa)
	A0A1L8F742	Uncharacterized protein. (498 aa)
	A0A1L8F737	Uncharacterized protein. (127 aa)
	adar	Uncharacterized protein. (1291 aa)
	A0A1L8F280	IG domain-containing protein. (218 aa)
	Tyro3.S	Uncharacterized protein. (832 aa)
	gfer	Sulfhydryl oxidase. (195 aa)
	Nlrc3.L	Uncharacterized protein. (986 aa)
	Nmi.L	Uncharacterized protein. (383 aa)
	A0A1L8EVD6	Macro domain-containing protein. (1005 aa)
	A0A1L8EV91	Poly [ADP-ribose] polymerase. (1677 aa)
	A0A1L8EV90	Poly [ADP-ribose] polymerase. (1589 aa)
	A0A1L8EV78	Poly [ADP-ribose] polymerase. (1832 aa)
	A0A1L8EV75	Poly [ADP-ribose] polymerase. (1831 aa)
	Parp14	Poly [ADP-ribose] polymerase. (1855 aa)
	A0A1L8EV72	Poly [ADP-ribose] polymerase. (1818 aa)
	dhx58	Uncharacterized protein. (681 aa)
	A0A1L8EKN2	Uncharacterized protein. (748 aa)
	A0A1L8ENF5	Poly [ADP-ribose] polymerase. (1699 aa)
	A0A1L8ENP2	Poly [ADP-ribose] polymerase. (1822 aa)
	nmi	Uncharacterized protein. (431 aa)
	A0A1L8EQY6	Sulfhydryl oxidase. (93 aa)
	Dhx58.L	Uncharacterized protein. (682 aa)
	grn	Uncharacterized protein. (1107 aa)
	A0A1L8EU46	HD domain-containing protein. (476 aa)
	samhd1	Uncharacterized protein. (632 aa)
	A0A1L8EU76	HD domain-containing protein. (270 aa)
	mettl3	MGC81069 protein; Belongs to the MT-A70-like family. (573 aa)
	ptpn2	Tyrosine-protein phosphatase non-receptor type. (468 aa)
	timd4	MGC99322 protein. (224 aa)
	MGC131013	MGC131013 protein. (230 aa)
	atg12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (132 aa)
	A0A310U122	A to I editase domain-containing protein. (118 aa)
	A0A1L8I1A6	Uncharacterized protein. (606 aa)
	cactin-2	Uncharacterized protein. (789 aa)
	lyar-2	zf-LYAR domain-containing protein. (357 aa)
	otop1-2	Uncharacterized protein. (589 aa)
	A0A1L8HTB1	Uncharacterized protein. (583 aa)
	trafd1	Uncharacterized protein. (752 aa)
	cactin	Uncharacterized protein. (796 aa)
	cnot7	Uncharacterized protein. (285 aa)
	A0A1L8HKV4	Uncharacterized protein. (576 aa)
	otop1	Uncharacterized protein. (588 aa)
	lyar	zf-LYAR domain-containing protein. (353 aa)
	A0A1L8HJU8	Uncharacterized protein. (1056 aa)
	A0A1L8HJS1	Uncharacterized protein. (314 aa)
	acod1	Uncharacterized protein. (474 aa)
	Irg1.S	Uncharacterized protein. (474 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8G9F4	Dhx58.L	A0A1L8G9F4	A0A1L8ERQ4	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.482
A0A1L8G9F4	atg12	A0A1L8G9F4	A8E622	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.997
A0A1L8G9F4	dhx58	A0A1L8G9F4	A0A1L8EKI0	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.482
A0A1L8G9F4	nlrx1	A0A1L8G9F4	A0A1L8FLE8	Autophagy protein 5; Involved in autophagic vesicle formation.	NACHT domain-containing protein.	0.578
A0A1L8GKK8	Dhx58.L	A0A1L8GKK8	A0A1L8ERQ4	NACHT domain-containing protein.	Uncharacterized protein.	0.557
A0A1L8GKK8	dhx58	A0A1L8GKK8	A0A1L8EKI0	NACHT domain-containing protein.	Uncharacterized protein.	0.557
A0A1L8GKK8	nlrx1	A0A1L8GKK8	A0A1L8FLE8	NACHT domain-containing protein.	NACHT domain-containing protein.	0.578
Dhx58.L	A0A1L8G9F4	A0A1L8ERQ4	A0A1L8G9F4	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.482
Dhx58.L	A0A1L8GKK8	A0A1L8ERQ4	A0A1L8GKK8	Uncharacterized protein.	NACHT domain-containing protein.	0.557
Dhx58.L	atg12	A0A1L8ERQ4	A8E622	Uncharacterized protein.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.486
Dhx58.L	dhx58	A0A1L8ERQ4	A0A1L8EKI0	Uncharacterized protein.	Uncharacterized protein.	0.900
Dhx58.L	nlrx1	A0A1L8ERQ4	A0A1L8FLE8	Uncharacterized protein.	NACHT domain-containing protein.	0.407
Drd2.L	Drd2.S	A0A1L8FLX5	A0A1L8FG13	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.900
Drd2.S	Drd2.L	A0A1L8FG13	A0A1L8FLX5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.900
Tnfaip3.S	Tyro3.S	A0A1L8G2B0	A0A1L8EZQ6	Uncharacterized protein.	Uncharacterized protein.	0.556
Tyro3.S	Tnfaip3.S	A0A1L8EZQ6	A0A1L8G2B0	Uncharacterized protein.	Uncharacterized protein.	0.556
Ythdf2.L	cnot7	A0A1L8HEE7	A0A1L8HLG5	YTH domain-containing protein.	Uncharacterized protein.	0.738
Ythdf2.L	mettl3	A0A1L8HEE7	Q6NUC3	YTH domain-containing protein.	MGC81069 protein; Belongs to the MT-A70-like family.	0.605
Ythdf2.S	cnot7	A0A1L8H7F2	A0A1L8HLG5	YTH domain-containing protein.	Uncharacterized protein.	0.442
Ythdf2.S	mettl3	A0A1L8H7F2	Q6NUC3	YTH domain-containing protein.	MGC81069 protein; Belongs to the MT-A70-like family.	0.604