(28 nodes) Positive regulation of isotype switching network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	clcf1-2	Uncharacterized protein. (223 aa)
	A0A1L8EKQ5	Uncharacterized protein. (534 aa)
	A0A1L8EME5	Uncharacterized protein. (328 aa)
	A0A1L8ENC4	AAA domain-containing protein. (1731 aa)
	rif1	Rif1_N domain-containing protein. (2326 aa)
	A0A1L8ES01	Uncharacterized protein. (552 aa)
	cd40	TNFR-Cys domain-containing protein. (280 aa)
	atad5	AAA domain-containing protein. (1740 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	clcf1	Uncharacterized protein. (223 aa)
	kmt5c	SET domain-containing protein. (827 aa)
	exosc3	MGC84934 protein. (250 aa)
	mlh1	DNA mismatch repair protein MutL-homolog 1. (750 aa)
	A0A1L8I2B2	Uncharacterized protein. (248 aa)
	nsd2	Uncharacterized protein. (1300 aa)
	Nsd2.S	Uncharacterized protein. (1300 aa)
	tp53bp1	Uncharacterized protein. (2179 aa)
	A0A1L8GSW6	Uncharacterized protein. (2175 aa)
	Hmces.L	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (365 aa)
	A0A1L8GN98	Uncharacterized protein. (1290 aa)
	A0A1L8GLH9	RNase_PH domain-containing protein. (268 aa)
	kmt5b-2	SET domain-containing protein. (877 aa)
	A0A1L8GGJ1	Uncharacterized protein. (1173 aa)
	kmt5b	SET domain-containing protein. (855 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	A0A1L8G1M7	Uncharacterized protein. (134 aa)
	Kmt5c.L	SET domain-containing protein. (761 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EME5	A0A1L8GGJ1	A0A1L8EME5	A0A1L8GGJ1	Uncharacterized protein.	Uncharacterized protein.	0.400
A0A1L8EME5	A0A1L8GN98	A0A1L8EME5	A0A1L8GN98	Uncharacterized protein.	Uncharacterized protein.	0.400
A0A1L8EME5	cd40	A0A1L8EME5	A0A1L8ETV2	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.901
A0A1L8ENC4	msh2	A0A1L8ENC4	A0A1L8G6D6	AAA domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.474
A0A1L8G1M7	A0A1L8GSW6	A0A1L8G1M7	A0A1L8GSW6	Uncharacterized protein.	Uncharacterized protein.	0.422
A0A1L8G1M7	A0A1L8I2B2	A0A1L8G1M7	A0A1L8I2B2	Uncharacterized protein.	Uncharacterized protein.	0.578
A0A1L8G1M7	Hmces.L	A0A1L8G1M7	A0A1L8GPQ0	Uncharacterized protein.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.433
A0A1L8G1M7	rif1	A0A1L8G1M7	A0A1L8EP28	Uncharacterized protein.	Rif1_N domain-containing protein.	0.566
A0A1L8G1M7	tp53bp1	A0A1L8G1M7	A0A1L8H0P7	Uncharacterized protein.	Uncharacterized protein.	0.422
A0A1L8GGJ1	A0A1L8EME5	A0A1L8GGJ1	A0A1L8EME5	Uncharacterized protein.	Uncharacterized protein.	0.400
A0A1L8GGJ1	cd40	A0A1L8GGJ1	A0A1L8ETV2	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.400
A0A1L8GLH9	exosc3	A0A1L8GLH9	Q58E93	RNase_PH domain-containing protein.	MGC84934 protein.	0.998
A0A1L8GN98	A0A1L8EME5	A0A1L8GN98	A0A1L8EME5	Uncharacterized protein.	Uncharacterized protein.	0.400
A0A1L8GN98	cd40	A0A1L8GN98	A0A1L8ETV2	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.400
A0A1L8GSW6	A0A1L8G1M7	A0A1L8GSW6	A0A1L8G1M7	Uncharacterized protein.	Uncharacterized protein.	0.422
A0A1L8GSW6	Nsd2.S	A0A1L8GSW6	A0A1L8HKN1	Uncharacterized protein.	Uncharacterized protein.	0.615
A0A1L8GSW6	nsd2	A0A1L8GSW6	A0A1L8HT85	Uncharacterized protein.	Uncharacterized protein.	0.615
A0A1L8GSW6	rif1	A0A1L8GSW6	A0A1L8EP28	Uncharacterized protein.	Rif1_N domain-containing protein.	0.809
A0A1L8I2B2	A0A1L8G1M7	A0A1L8I2B2	A0A1L8G1M7	Uncharacterized protein.	Uncharacterized protein.	0.578
A0A1L8I2B2	rif1	A0A1L8I2B2	A0A1L8EP28	Uncharacterized protein.	Rif1_N domain-containing protein.	0.543