(31 nodes) Positive regulation of smoothened signaling pathway network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	dhh-2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	gli1	Uncharacterized protein. (1361 aa)
	dhh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (398 aa)
	Ulk3.L	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (468 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	txndc15	Thioredoxin domain-containing protein. (342 aa)
	A0A1L8GW56	Uncharacterized protein. (978 aa)
	A0A1L8GQK0	Uncharacterized protein. (1478 aa)
	gorab-2	Uncharacterized protein. (365 aa)
	Uchl5.L	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	scube2-2	Uncharacterized protein. (946 aa)
	gorab	Uncharacterized protein. (165 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	Gas8.S	GAS domain-containing protein. (484 aa)
	scube2	Uncharacterized protein. (1003 aa)
	ift172	Uncharacterized protein. (1749 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	A0A1L8FQM4	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (429 aa)
	stk36	Protein kinase domain-containing protein. (1264 aa)
	ihh-2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	fam92a-b	Protein FAM92A-B; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Plays a role in ciliogenesis. (285 aa)
	tubd1	Tubd1-A-prov protein; Belongs to the tubulin family. (451 aa)
	fam92a-a	Protein FAM92A-A; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Plays a role in ciliogenesis (By similarity). (284 aa)
	gas1-2	Uncharacterized protein. (284 aa)
	evc	Uncharacterized protein. (928 aa)
	gas1	Uncharacterized protein. (299 aa)
	Intu.S	PDZ domain-containing protein. (951 aa)
	Dync2h1.L	Uncharacterized protein. (2548 aa)
	Gli1.L	Uncharacterized protein. (1362 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FQM4	Gli1.L	A0A1L8FQM4	A0A1L8HI29	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein.	0.647
A0A1L8FQM4	Smo.L	A0A1L8FQM4	A0A1L8GZN4	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.938
A0A1L8FQM4	Smo.S	A0A1L8FQM4	A0A1L8GTP2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.938
A0A1L8FQM4	gas1	A0A1L8FQM4	A0A1L8HPA8	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein.	0.871
A0A1L8FQM4	gas1-2	A0A1L8FQM4	A0A1L8HYD8	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein.	0.871
A0A1L8FQM4	gli1	A0A1L8FQM4	A0A1L8HA22	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein.	0.647
Dync2h1.L	evc	A0A1L8HJ96	A0A1L8HTF5	Uncharacterized protein.	Uncharacterized protein.	0.581
Dync2h1.L	ift172	A0A1L8HJ96	A0A1L8GCV5	Uncharacterized protein.	Uncharacterized protein.	0.712
Gas8.S	Smo.L	A0A1L8GER3	A0A1L8GZN4	GAS domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.693
Gas8.S	Smo.S	A0A1L8GER3	A0A1L8GTP2	GAS domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.693
Gli1.L	A0A1L8FQM4	A0A1L8HI29	A0A1L8FQM4	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.647
Gli1.L	Intu.S	A0A1L8HI29	A0A1L8HLW4	Uncharacterized protein.	PDZ domain-containing protein.	0.415
Gli1.L	Shh.L	A0A1L8HI29	A0A1L8FV87	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.913
Gli1.L	Smo.L	A0A1L8HI29	A0A1L8GZN4	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.966
Gli1.L	Smo.S	A0A1L8HI29	A0A1L8GTP2	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.966
Gli1.L	Ulk3.L	A0A1L8HI29	A0A1L8H051	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.690
Gli1.L	dhh	A0A1L8HI29	A0A1L8H9I2	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.746
Gli1.L	dhh-2	A0A1L8HI29	A0A1L8HHS2	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.811
Gli1.L	evc	A0A1L8HI29	A0A1L8HTF5	Uncharacterized protein.	Uncharacterized protein.	0.561
Gli1.L	gas1	A0A1L8HI29	A0A1L8HPA8	Uncharacterized protein.	Uncharacterized protein.	0.480