(36 nodes) Synaptic vesicle transport network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ctnnb1-2	Ctnnb1-prov protein. (781 aa)
	A0A1L8EVW1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (958 aa)
	Picalm.2.L	ENTH domain-containing protein. (652 aa)
	picalml	ENTH domain-containing protein. (656 aa)
	A0A1L8F8A0	Uncharacterized protein. (188 aa)
	Bloc1s2.S	Uncharacterized protein. (290 aa)
	kif5b	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (962 aa)
	A0A1L8EP18	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (959 aa)
	A0A1L8FVE2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (962 aa)
	bloc1s5	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (188 aa)
	Dtnbp1.L	Uncharacterized protein. (317 aa)
	Bloc1s4.L	Uncharacterized protein. (217 aa)
	snap91	ENTH domain-containing protein. (909 aa)
	A0A1L8G9T2	ENTH domain-containing protein. (901 aa)
	A0A1L8GS63	Uncharacterized protein. (120 aa)
	Bloc1s6.S	Uncharacterized protein. (225 aa)
	A0A1L8GT81	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1101 aa)
	A0A1L8H071	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1092 aa)
	A0A1L8H0L4	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (168 aa)
	spg11	Spatacsin_C domain-containing protein. (2345 aa)
	Tmem230.L	Uncharacterized protein. (144 aa)
	ap3m2	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (418 aa)
	synj1	SAC domain-containing protein. (1544 aa)
	A0A1L8H9U2	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1028 aa)
	A0A1L8HB72	ENTH domain-containing protein. (623 aa)
	Synj1.L	Uncharacterized protein. (2634 aa)
	A0A1L8HI40	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1028 aa)
	picalm	ENTH domain-containing protein. (700 aa)
	ap3d1	Adaptin_N domain-containing protein. (1236 aa)
	ap3b2	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1096 aa)
	ap3d1-2	Adaptin_N domain-containing protein. (1236 aa)
	Ap3b1.L	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1099 aa)
	bloc1s2	LOC100036972 protein. (152 aa)
	ap3m2-2	LOC496052 protein; Belongs to the adaptor complexes medium subunit family. (418 aa)
	snapin	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (122 aa)
	ctnnb1	Beta-catenin protein. (781 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8F8A0	A0A1L8GT81	A0A1L8F8A0	A0A1L8GT81	Uncharacterized protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.420
A0A1L8F8A0	A0A1L8H071	A0A1L8F8A0	A0A1L8H071	Uncharacterized protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.420
A0A1L8F8A0	A0A1L8H0L4	A0A1L8F8A0	A0A1L8H0L4	Uncharacterized protein.	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	0.929
A0A1L8F8A0	Ap3b1.L	A0A1L8F8A0	A0A1L8I242	Uncharacterized protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.420
A0A1L8F8A0	Bloc1s2.S	A0A1L8F8A0	A0A1L8FEU7	Uncharacterized protein.	Uncharacterized protein.	0.595
A0A1L8F8A0	Bloc1s4.L	A0A1L8F8A0	A0A1L8FY80	Uncharacterized protein.	Uncharacterized protein.	0.893
A0A1L8F8A0	Bloc1s6.S	A0A1L8F8A0	A0A1L8GST9	Uncharacterized protein.	Uncharacterized protein.	0.929
A0A1L8F8A0	Dtnbp1.L	A0A1L8F8A0	A0A1L8FY33	Uncharacterized protein.	Uncharacterized protein.	0.796
A0A1L8F8A0	ap3b2	A0A1L8F8A0	A0A1L8HRF7	Uncharacterized protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.420
A0A1L8F8A0	bloc1s2	A0A1L8F8A0	A1L2W6	Uncharacterized protein.	LOC100036972 protein.	0.595
A0A1L8F8A0	bloc1s5	A0A1L8F8A0	A0A1L8FXX2	Uncharacterized protein.	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).	0.791
A0A1L8F8A0	snapin	A0A1L8F8A0	Q5PPY9	Uncharacterized protein.	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...]	0.765
A0A1L8G9T2	A0A1L8GT81	A0A1L8G9T2	A0A1L8GT81	ENTH domain-containing protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.414
A0A1L8G9T2	A0A1L8H071	A0A1L8G9T2	A0A1L8H071	ENTH domain-containing protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.414
A0A1L8G9T2	Ap3b1.L	A0A1L8G9T2	A0A1L8I242	ENTH domain-containing protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.414
A0A1L8G9T2	ap3b2	A0A1L8G9T2	A0A1L8HRF7	ENTH domain-containing protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.414
A0A1L8G9T2	ap3d1	A0A1L8G9T2	A0A1L8HNG4	ENTH domain-containing protein.	Adaptin_N domain-containing protein.	0.457
A0A1L8G9T2	ap3d1-2	A0A1L8G9T2	A0A1L8HWU3	ENTH domain-containing protein.	Adaptin_N domain-containing protein.	0.457
A0A1L8GT81	A0A1L8F8A0	A0A1L8GT81	A0A1L8F8A0	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	Uncharacterized protein.	0.420
A0A1L8GT81	A0A1L8G9T2	A0A1L8GT81	A0A1L8G9T2	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	ENTH domain-containing protein.	0.414