(19 nodes) Amyloid-beta metabolic process network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mgat3-2	Uncharacterized protein. (544 aa)
	bace2	MGC68482 protein; Belongs to the peptidase A1 family. (499 aa)
	psenen-2	LOC494701 protein. (101 aa)
	psenen	LOC495936 protein. (101 aa)
	Bace2.L	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (500 aa)
	Apeh.L	Peptidase_S9 domain-containing protein. (728 aa)
	mgat3	Uncharacterized protein. (502 aa)
	A0A1L8G7M0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (445 aa)
	psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (449 aa)
	bace1-2	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (503 aa)
	Ide.L	Uncharacterized protein; Belongs to the peptidase M16 family. (978 aa)
	bace1	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (503 aa)
	ide	Uncharacterized protein; Belongs to the peptidase M16 family. (1011 aa)
	ncstn-2	Ncstrn_small domain-containing protein. (713 aa)
	aph1a	Uncharacterized protein. (247 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	A0A1L8F4N0	Uncharacterized protein. (219 aa)
	ncstn	Ncstrn_small domain-containing protein. (713 aa)
	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EZY9	A0A1L8F4N0	A0A1L8EZY9	A0A1L8F4N0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.935
A0A1L8EZY9	A0A1L8G7M0	A0A1L8EZY9	A0A1L8G7M0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.977
A0A1L8EZY9	aph1a	A0A1L8EZY9	A0A1L8FCC5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.986
A0A1L8EZY9	bace1	A0A1L8EZY9	A0A1L8FFW8	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.648
A0A1L8EZY9	bace1-2	A0A1L8EZY9	A0A1L8FLK2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.648
A0A1L8EZY9	ncstn	A0A1L8EZY9	A0A1L8F4M3	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Ncstrn_small domain-containing protein.	0.999
A0A1L8EZY9	ncstn-2	A0A1L8EZY9	A0A1L8FCM9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Ncstrn_small domain-containing protein.	0.999
A0A1L8EZY9	psen1	A0A1L8EZY9	A0A1L8FAH5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.900
A0A1L8EZY9	psen2	A0A1L8EZY9	A0A1L8G245	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.977
A0A1L8EZY9	psenen	A0A1L8EZY9	Q5PQA0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	LOC495936 protein.	0.997
A0A1L8EZY9	psenen-2	A0A1L8EZY9	Q640D2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	LOC494701 protein.	0.997
A0A1L8F4N0	A0A1L8EZY9	A0A1L8F4N0	A0A1L8EZY9	Uncharacterized protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.935
A0A1L8F4N0	A0A1L8G7M0	A0A1L8F4N0	A0A1L8G7M0	Uncharacterized protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.927
A0A1L8F4N0	ncstn	A0A1L8F4N0	A0A1L8F4M3	Uncharacterized protein.	Ncstrn_small domain-containing protein.	0.977
A0A1L8F4N0	ncstn-2	A0A1L8F4N0	A0A1L8FCM9	Uncharacterized protein.	Ncstrn_small domain-containing protein.	0.977
A0A1L8F4N0	psen1	A0A1L8F4N0	A0A1L8FAH5	Uncharacterized protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.935
A0A1L8F4N0	psen2	A0A1L8F4N0	A0A1L8G245	Uncharacterized protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.927
A0A1L8F4N0	psenen	A0A1L8F4N0	Q5PQA0	Uncharacterized protein.	LOC495936 protein.	0.975
A0A1L8F4N0	psenen-2	A0A1L8F4N0	Q640D2	Uncharacterized protein.	LOC494701 protein.	0.975
A0A1L8G7M0	A0A1L8EZY9	A0A1L8G7M0	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.977