STRINGSTRING
sirt6 sirt6 A0A1L8EKH9 A0A1L8EKH9 A0A1L8EKN2 A0A1L8EKN2 A0A1L8EKQ1 A0A1L8EKQ1 Itga4.S Itga4.S A0A1L8EPQ2 A0A1L8EPQ2 A0A1L8EPQ9 A0A1L8EPQ9 Bmpr2.S Bmpr2.S A0A1L8EPT8 A0A1L8EPT8 Stat3.2.L Stat3.2.L stat3.1 stat3.1 med1l med1l grn grn A0A1L8ETH9 A0A1L8ETH9 A0A1L8ETM5 A0A1L8ETM5 itga4 itga4 bmpr2 bmpr2 tnf tnf A0A1L8F4G3 A0A1L8F4G3 nrarp nrarp A0A1L8FBW7 A0A1L8FBW7 A0A1L8FBY0 A0A1L8FBY0 sirt1 sirt1 emc10 emc10 Hpn.S Hpn.S Sirt1.L Sirt1.L Emc10.L Emc10.L A0A1L8FQN9 A0A1L8FQN9 Tgfbr1.S Tgfbr1.S rreb1 rreb1 Bmp6.S Bmp6.S A0A1L8FT81 A0A1L8FT81 osr2 osr2 A0A1L8FTT4 A0A1L8FTT4 Myc.S Myc.S A0A1L8FVD4 A0A1L8FVD4 Dlx5.L Dlx5.L Med1.L Med1.L A0A1L8FX26 A0A1L8FX26 bmp6 bmp6 rreb1-2 rreb1-2 Cyp7b1.L Cyp7b1.L osr2-2 osr2-2 A0A1L8G189 A0A1L8G189 vash2 vash2 bmp2 bmp2 vip vip Tnfaip3.S Tnfaip3.S A0A1L8G3R8 A0A1L8G3R8 tp63 tp63 agtr1 agtr1 Scg2.S Scg2.S adam17 adam17 osr1 osr1 Bmp2.L Bmp2.L vash2-2 vash2-2 A0A1L8G6C6 A0A1L8G6C6 tp63-2 tp63-2 cldn1 cldn1 agtr1-2 agtr1-2 scg2 scg2 osr1-2 osr1-2 A0A1L8GCB2 A0A1L8GCB2 igf2 igf2 mdk mdk Mst1.S Mst1.S Mdk.L Mdk.L igf2-2 igf2-2 A0A1L8GJQ1 A0A1L8GJQ1 Jun.L Jun.L pdgfb pdgfb mst1 mst1 Prok2.L Prok2.L A0A1L8GQ72 A0A1L8GQ72 A0A1L8GQJ5 A0A1L8GQJ5 A0A1L8GRA3 A0A1L8GRA3 nkx2-6 nkx2-6 Tgfa.S Tgfa.S fgf7 fgf7 Smo.S Smo.S A0A1L8GU52 A0A1L8GU52 fgf1 fgf1 A0A1L8GVX6 A0A1L8GVX6 A0A1L8GWS1 A0A1L8GWS1 fgf1-2 fgf1-2 A0A1L8GXP7 A0A1L8GXP7 nkx2-5 nkx2-5 cav2 cav2 A0A1L8GYV6 A0A1L8GYV6 Smo.L Smo.L Map2k5.L Map2k5.L tgfa tgfa Nkx2-6.L Nkx2-6.L il10 il10 Kdm5b.S Kdm5b.S A0A1L8H7W4 A0A1L8H7W4 Nf1.S Nf1.S A0A1L8H9B5 A0A1L8H9B5 Acvrl1.S Acvrl1.S Nr4a1.S Nr4a1.S sp1 sp1 Pdx1.S Pdx1.S A0A1L8HAR8 A0A1L8HAR8 Vegfd.L Vegfd.L A0A1L8HEI9 A0A1L8HEI9 il10-2 il10-2 A0A1L8HF02 A0A1L8HF02 nf1 nf1 nr4a1 nr4a1 acvrl1 acvrl1 sp1-2 sp1-2 pdx1 pdx1 kdr kdr Vegfc.S Vegfc.S A0A1L8HLH7 A0A1L8HLH7 fgf2 fgf2 epgn epgn gas1 gas1 Aplnr.S Aplnr.S A0A1L8HQW3 A0A1L8HQW3 aggf1 aggf1 A0A1L8HTZ2 A0A1L8HTZ2 vegfc vegfc Epgn.L Epgn.L odam odam lrg1 lrg1 mydgf mydgf A0A1L8HYA8 A0A1L8HYA8 gas1-2 gas1-2 aplnr aplnr A0A1L8I199 A0A1L8I199 aggf1-2 aggf1-2 A0A310TLP0 A0A310TLP0 MGC82408 MGC82408 apln apln prok2 prok2 LOC100037190 LOC100037190 tnf-2 tnf-2 fgf2-2 fgf2-2 bmp4 bmp4 nog nog itgb3 itgb3 vegfa vegfa dlx6 dlx6 adam17-2 adam17-2 dlx6-2 dlx6-2 fgf7-2 fgf7-2 ctnnb1 ctnnb1 ccr2 ccr2 pdgfb-2 pdgfb-2 myc myc nkx2-5-2 nkx2-5-2 ctnnb1-2 ctnnb1-2 vip-2 vip-2 cldn1-2 cldn1-2 bmp4-2 bmp4-2 c-Jun c-Jun dlx5 dlx5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sirt6MGC82564 protein. (331 aa)
A0A1L8EKH9STAT_int domain-containing protein. (635 aa)
A0A1L8EKN2Uncharacterized protein. (748 aa)
A0A1L8EKQ1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1570 aa)
Itga4.SIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1073 aa)
A0A1L8EPQ2Uncharacterized protein. (181 aa)
A0A1L8EPQ9Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (130 aa)
Bmpr2.SUncharacterized protein. (383 aa)
A0A1L8EPT8Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (144 aa)
Stat3.2.LSignal transducer and activator of transcription. (760 aa)
stat3.1Signal transducer and activator of transcription. (769 aa)
med1lMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1570 aa)
grnUncharacterized protein. (1107 aa)
A0A1L8ETH9WD_REPEATS_REGION domain-containing protein. (1350 aa)
A0A1L8ETM5Uncharacterized protein. (519 aa)
itga4Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1027 aa)
bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1054 aa)
tnfTNF_2 domain-containing protein. (227 aa)
A0A1L8F4G3Uncharacterized protein. (453 aa)
nrarpANK_REP_REGION domain-containing protein. (114 aa)
A0A1L8FBW7Uncharacterized protein. (306 aa)
A0A1L8FBY0Uncharacterized protein. (453 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (722 aa)
emc10Uncharacterized protein. (277 aa)
Hpn.SPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (386 aa)
Sirt1.LDeacetylase sirtuin-type domain-containing protein. (722 aa)
Emc10.LUncharacterized protein. (267 aa)
A0A1L8FQN9Uncharacterized protein. (1257 aa)
Tgfbr1.SSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (454 aa)
rreb1Uncharacterized protein. (1635 aa)
Bmp6.STGF_BETA_2 domain-containing protein. (448 aa)
A0A1L8FT81Uncharacterized protein; Belongs to the cytochrome P450 family. (361 aa)
osr2Uncharacterized protein. (271 aa)
A0A1L8FTT4BHLH domain-containing protein. (191 aa)
Myc.SMyc_N domain-containing protein. (176 aa)
A0A1L8FVD4Uncharacterized protein. (1265 aa)
Dlx5.LHomeobox domain-containing protein. (298 aa)
Med1.LMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (649 aa)
A0A1L8FX26Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (487 aa)
bmp6TGF_BETA_2 domain-containing protein. (448 aa)
rreb1-2Uncharacterized protein. (1686 aa)
Cyp7b1.LUncharacterized protein; Belongs to the cytochrome P450 family. (499 aa)
osr2-2Uncharacterized protein. (312 aa)
A0A1L8G189Homeobox domain-containing protein. (381 aa)
vash2Uncharacterized protein. (377 aa)
bmp2TGF_BETA_2 domain-containing protein. (398 aa)
vipGLUCAGON domain-containing protein. (201 aa)
Tnfaip3.SUncharacterized protein. (781 aa)
A0A1L8G3R8G_PROTEIN_RECEP_F1_2 domain-containing protein. (459 aa)
tp63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
agtr1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
Scg2.SUncharacterized protein. (621 aa)
adam17Uncharacterized protein. (855 aa)
osr1Uncharacterized protein. (259 aa)
Bmp2.LTGF_BETA_2 domain-containing protein. (398 aa)
vash2-2Uncharacterized protein. (377 aa)
A0A1L8G6C6Homeobox domain-containing protein. (387 aa)
tp63-2Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
cldn1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
agtr1-2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
scg2Uncharacterized protein. (611 aa)
osr1-2Uncharacterized protein. (259 aa)
A0A1L8GCB2Uncharacterized protein. (3837 aa)
igf2IlGF domain-containing protein. (217 aa)
mdkUncharacterized protein. (142 aa)
Mst1.SUncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (716 aa)
Mdk.LUncharacterized protein. (173 aa)
igf2-2IlGF domain-containing protein. (217 aa)
A0A1L8GJQ1Uncharacterized protein. (151 aa)
Jun.LBZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
pdgfbPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (241 aa)
mst1Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa)
Prok2.LProkineticin domain-containing protein. (111 aa)
A0A1L8GQ72Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (264 aa)
A0A1L8GQJ5Uncharacterized protein. (161 aa)
A0A1L8GRA3Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1398 aa)
nkx2-6Homeobox domain-containing protein. (262 aa)
Tgfa.SEGF-like domain-containing protein. (159 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Smo.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
A0A1L8GU52Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (333 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
A0A1L8GVX6Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (329 aa)
A0A1L8GWS1Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
fgf1-2Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
A0A1L8GXP7Uncharacterized protein. (147 aa)
nkx2-5Homeobox domain-containing protein. (300 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
A0A1L8GYV6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Smo.LUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
Map2k5.LUncharacterized protein; Belongs to the protein kinase superfamily. (428 aa)
tgfaEGF-like domain-containing protein. (160 aa)
Nkx2-6.LHomeobox domain-containing protein. (263 aa)
il10Uncharacterized protein. (172 aa)
Kdm5b.SUncharacterized protein. (1585 aa)
A0A1L8H7W4Uncharacterized protein. (139 aa)
Nf1.SUncharacterized protein. (2774 aa)
A0A1L8H9B5Uncharacterized protein. (111 aa)
Acvrl1.SReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
Nr4a1.SUncharacterized protein. (653 aa)
sp1Uncharacterized protein. (732 aa)
Pdx1.SHomeobox domain-containing protein. (271 aa)
A0A1L8HAR8Uncharacterized protein. (139 aa)
Vegfd.LPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (306 aa)
A0A1L8HEI9Uncharacterized protein. (1518 aa)
il10-2Uncharacterized protein. (170 aa)
A0A1L8HF02Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
nf1Uncharacterized protein. (2759 aa)
nr4a1Uncharacterized protein. (584 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
sp1-2Uncharacterized protein. (722 aa)
pdx1Homeobox domain-containing protein. (271 aa)
kdrUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1326 aa)
Vegfc.SPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (407 aa)
A0A1L8HLH7Uncharacterized protein. (54 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
epgnEGF-like domain-containing protein. (139 aa)
gas1Uncharacterized protein. (299 aa)
Aplnr.SG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
A0A1L8HQW3BZIP domain-containing protein. (433 aa)
aggf1Uncharacterized protein. (696 aa)
A0A1L8HTZ2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
vegfcPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (402 aa)
Epgn.LEGF-like domain-containing protein. (139 aa)
odamUncharacterized protein. (211 aa)
lrg1LRRCT domain-containing protein. (362 aa)
mydgfUncharacterized protein. (158 aa)
A0A1L8HYA8BZIP domain-containing protein. (436 aa)
gas1-2Uncharacterized protein. (284 aa)
aplnrG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
A0A1L8I199BZIP domain-containing protein. (390 aa)
aggf1-2Uncharacterized protein. (688 aa)
A0A310TLP0G_PROTEIN_RECEP_F1_2 domain-containing protein. (293 aa)
MGC82408Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
aplnApln-b protein. (76 aa)
prok2LOC100037158 protein. (111 aa)
LOC100037190LOC100037190 protein. (331 aa)
tnf-2Tumor necrosis factor alpha. (225 aa)
fgf2-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
bmp4Bone morphogenetic protein 4. (401 aa)
nogNoggin; Belongs to the noggin family. (222 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
vegfaVascular endothelial growth factor 196; Belongs to the PDGF/VEGF growth factor family. (194 aa)
dlx6LOC443711 protein. (260 aa)
adam17-2Disintegrin metalloproteinase. (839 aa)
dlx6-2MGC130625 protein. (253 aa)
fgf7-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
ctnnb1Beta-catenin protein. (781 aa)
ccr2LOC494705 protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
pdgfb-2Pdgfb protein; Belongs to the PDGF/VEGF growth factor family. (213 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
nkx2-5-2Nkx2.5 protein. (299 aa)
ctnnb1-2Ctnnb1-prov protein. (781 aa)
vip-2Vip-A protein. (202 aa)
cldn1-2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
bmp4-2Bone morphogenetic protein 4. (400 aa)
c-JunC-Jun protein; Belongs to the bZIP family. (312 aa)
dlx5Homeobox domain-containing protein. (297 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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