(36 nodes) Smooth muscle cell differentiation network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8EMD1	Uncharacterized protein. (162 aa)
	myocd	SAP domain-containing protein. (960 aa)
	A0A1L8EP11	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
	MRTF-B	SAP domain-containing protein. (1066 aa)
	tmem204	Uncharacterized protein. (223 aa)
	Myocd.L	SAP domain-containing protein. (959 aa)
	Acvr1.L	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (624 aa)
	A0A1L8EXH2	SAP domain-containing protein. (1093 aa)
	A0A1L8EXH7	Uncharacterized protein. (72 aa)
	tmem204-2	Uncharacterized protein. (223 aa)
	A0A1L8F1K8	Uncharacterized protein. (572 aa)
	Ednrb2.S	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	ednrb2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (433 aa)
	gata6	Uncharacterized protein. (502 aa)
	A0A1L8FYS5	GATA-type domain-containing protein. (466 aa)
	srf	MADS-box domain-containing protein. (449 aa)
	qki	KH domain-containing protein. (365 aa)
	srf-2	MADS-box domain-containing protein. (448 aa)
	qki-2	KH domain-containing protein. (342 aa)
	mrtfa	SAP domain-containing protein. (1020 aa)
	A0A1L8GNL0	SAP domain-containing protein. (1025 aa)
	A0A1L8H804	TBX domain-containing protein. (642 aa)
	ednrb	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (431 aa)
	ednrb-2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (431 aa)
	nfatc4	RHD domain-containing protein. (1086 aa)
	nfatc4-2	RHD domain-containing protein. (1081 aa)
	A0A310UDT2	Uncharacterized protein. (610 aa)
	ednra	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	tbx3-A	Transcription repression factor Tbx3. (716 aa)
	Tbx2	T-box transcription factor Tbx2. (688 aa)
	mespa	BHLH transcription factor mespa. (283 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	ctnnb1-2	Ctnnb1-prov protein. (781 aa)
	ednra-2	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	tbx3	Transcription factor Tbx3. (711 aa)
	mecp2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (467 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EP11	A0A1L8F1K8	A0A1L8EP11	A0A1L8F1K8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.483
A0A1L8EP11	A0A310UDT2	A0A1L8EP11	A0A310UDT2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.483
A0A1L8EXH2	srf	A0A1L8EXH2	A0A1L8G0Z2	SAP domain-containing protein.	MADS-box domain-containing protein.	0.766
A0A1L8EXH2	srf-2	A0A1L8EXH2	A0A1L8G721	SAP domain-containing protein.	MADS-box domain-containing protein.	0.766
A0A1L8EXH7	srf	A0A1L8EXH7	A0A1L8G0Z2	Uncharacterized protein.	MADS-box domain-containing protein.	0.766
A0A1L8EXH7	srf-2	A0A1L8EXH7	A0A1L8G721	Uncharacterized protein.	MADS-box domain-containing protein.	0.766
A0A1L8F1K8	A0A1L8EP11	A0A1L8F1K8	A0A1L8EP11	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.483
A0A1L8F1K8	Acvr1.L	A0A1L8F1K8	A0A1L8EW46	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.691
A0A1L8GNL0	srf	A0A1L8GNL0	A0A1L8G0Z2	SAP domain-containing protein.	MADS-box domain-containing protein.	0.766
A0A1L8GNL0	srf-2	A0A1L8GNL0	A0A1L8G721	SAP domain-containing protein.	MADS-box domain-containing protein.	0.766
A0A310UDT2	A0A1L8EP11	A0A310UDT2	A0A1L8EP11	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.483
A0A310UDT2	Acvr1.L	A0A310UDT2	A0A1L8EW46	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.483
Acvr1.L	A0A1L8F1K8	A0A1L8EW46	A0A1L8F1K8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Uncharacterized protein.	0.691
Acvr1.L	A0A310UDT2	A0A1L8EW46	A0A310UDT2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Uncharacterized protein.	0.483
Acvr1.L	ctnnb1	A0A1L8EW46	Q63ZT4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Beta-catenin protein.	0.436
Ednrb2.S	ednra	A0A1L8F377	A1L2P6	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	LOC100036912 protein; Belongs to the G-protein coupled receptor 1 family.	0.613
Ednrb2.S	ednra-2	A0A1L8F377	Q7ZXQ5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.613
MRTF-B	srf	A0A1L8EQ79	A0A1L8G0Z2	SAP domain-containing protein.	MADS-box domain-containing protein.	0.883
MRTF-B	srf-2	A0A1L8EQ79	A0A1L8G721	SAP domain-containing protein.	MADS-box domain-containing protein.	0.883
Myocd.L	gata6	A0A1L8EUS1	A0A1L8FSX7	SAP domain-containing protein.	Uncharacterized protein.	0.487