(75 nodes) Neuron apoptotic process network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MGC80089	Beta-synuclein; Belongs to the synuclein family. (133 aa)
	adnp	Uncharacterized protein. (1093 aa)
	dnajc5	J domain-containing protein. (197 aa)
	A0A1L8EP74	Homeobox domain-containing protein. (251 aa)
	adnp-2	Uncharacterized protein. (1097 aa)
	A0A1L8ET62	J domain-containing protein. (260 aa)
	Pigt.L	Uncharacterized protein. (578 aa)
	A0A1L8EWE8	Homeobox domain-containing protein. (251 aa)
	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	axl	Uncharacterized protein. (890 aa)
	A0A1L8F4K5	Tyrosine-protein kinase receptor. (864 aa)
	nes	IF rod domain-containing protein; Belongs to the intermediate filament family. (1875 aa)
	ncstn	Ncstrn_small domain-containing protein. (713 aa)
	aifm1	Uncharacterized protein. (637 aa)
	axl-2	Uncharacterized protein. (896 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	A0A1L8FC93	Tyrosine-protein kinase receptor. (804 aa)
	nes-2	IF rod domain-containing protein; Belongs to the intermediate filament family. (1954 aa)
	ncstn-2	Ncstrn_small domain-containing protein. (713 aa)
	Casp7.S	Uncharacterized protein; Belongs to the peptidase C14A family. (468 aa)
	A0A1L8FEK1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
	A0A1L8FFM1	Uncharacterized protein. (588 aa)
	Bax.L	Uncharacterized protein. (221 aa)
	Casp9.S	Uncharacterized protein; Belongs to the peptidase C14A family. (399 aa)
	Xcaspase-7	Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
	A0A1L8FKX2	Uncharacterized protein. (305 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	Rock1.S	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1367 aa)
	A0A1L8FT86	J domain-containing protein. (196 aa)
	Oxr1.S	LysM domain-containing protein. (754 aa)
	A0A1L8FXP7	BH4_2 domain-containing protein. (300 aa)
	Rock1.L	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
	A0A1L8FZ58	J domain-containing protein. (196 aa)
	oxr1	LysM domain-containing protein. (857 aa)
	cln8	TLC domain-containing protein. (285 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
	bok	Uncharacterized protein. (214 aa)
	Tnfrsf21.S	Uncharacterized protein. (567 aa)
	Dnajc5g.S	J domain-containing protein. (233 aa)
	tp63-2	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
	bok-2	Uncharacterized protein. (214 aa)
	tnfrsf21	Uncharacterized protein. (618 aa)
	Dnajc5g.L	J domain-containing protein. (235 aa)
	rapsn	Uncharacterized protein. (419 aa)
	Nae1.S	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
	fadd	Uncharacterized protein. (188 aa)
	rapsn-2	Uncharacterized protein. (419 aa)
	AARS	AA_TRNA_LIGASE_II_ALA domain-containing protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (1017 aa)
	nefl	IF rod domain-containing protein; Belongs to the intermediate filament family. (547 aa)
	polb	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (334 aa)
	A0A1L8GY03	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1205 aa)
	spg11	Spatacsin_C domain-containing protein. (2345 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	A0A1L8H4Q1	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa)
	A0A1L8H508	Uncharacterized protein. (135 aa)
	A0A1L8H564	BPTI/Kunitz inhibitor domain-containing protein. (751 aa)
	Nf1.S	Uncharacterized protein. (2774 aa)
	rb1	Uncharacterized protein. (899 aa)
	App.L	BPTI/Kunitz inhibitor domain-containing protein. (749 aa)
	nf1	Uncharacterized protein. (2759 aa)
	tmtc4	TPR_REGION domain-containing protein. (738 aa)
	ppargc1a	RRM domain-containing protein. (784 aa)
	nfatc4	RHD domain-containing protein. (1086 aa)
	Cit.S	Uncharacterized protein. (1714 aa)
	diablo	Uncharacterized protein. (258 aa)
	ppargc1a-2	RRM domain-containing protein. (786 aa)
	nfatc4-2	RHD domain-containing protein. (1081 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	cit	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2068 aa)
	Diablo.L	Uncharacterized protein. (258 aa)
	A0A310TNK6	Uncharacterized protein. (708 aa)
	fadd-2	Fas-associating death domain-containing protein. (188 aa)
	sncb	Beta-synuclein; Belongs to the synuclein family. (134 aa)
	cln8-2	MGC83128 protein. (290 aa)
	lig4	DNA ligase. (911 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EZY9	A0A1L8H564	A0A1L8EZY9	A0A1L8H564	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	BPTI/Kunitz inhibitor domain-containing protein.	0.933
A0A1L8EZY9	App.L	A0A1L8EZY9	A0A1L8HCN6	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	BPTI/Kunitz inhibitor domain-containing protein.	0.964
A0A1L8EZY9	Bcl2.S	A0A1L8EZY9	A0A1L8FSA4	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	BH4_2 domain-containing protein.	0.430
A0A1L8EZY9	ncstn	A0A1L8EZY9	A0A1L8F4M3	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Ncstrn_small domain-containing protein.	0.999
A0A1L8EZY9	ncstn-2	A0A1L8EZY9	A0A1L8FCM9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Ncstrn_small domain-containing protein.	0.999
A0A1L8EZY9	psen1	A0A1L8EZY9	A0A1L8FAH5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.900
A0A1L8F4K5	A0A1L8FC93	A0A1L8F4K5	A0A1L8FC93	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.900
A0A1L8F4K5	Nf1.S	A0A1L8F4K5	A0A1L8H8D7	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.514
A0A1L8F4K5	fgf8	A0A1L8F4K5	Q8AXC5	Tyrosine-protein kinase receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.685
A0A1L8FC93	A0A1L8F4K5	A0A1L8FC93	A0A1L8F4K5	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.900
A0A1L8FC93	Nf1.S	A0A1L8FC93	A0A1L8H8D7	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.514
A0A1L8FC93	fgf8	A0A1L8FC93	Q8AXC5	Tyrosine-protein kinase receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.685
A0A1L8FXP7	A0A1L8GY03	A0A1L8FXP7	A0A1L8GY03	BH4_2 domain-containing protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.722
A0A1L8FXP7	A0A1L8H4Q1	A0A1L8FXP7	A0A1L8H4Q1	BH4_2 domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.845
A0A1L8FXP7	A0A310TNK6	A0A1L8FXP7	A0A310TNK6	BH4_2 domain-containing protein.	Uncharacterized protein.	0.598
A0A1L8FXP7	Bax.L	A0A1L8FXP7	A0A1L8FH04	BH4_2 domain-containing protein.	Uncharacterized protein.	0.996
A0A1L8FXP7	Bcl2.S	A0A1L8FXP7	A0A1L8FSA4	BH4_2 domain-containing protein.	BH4_2 domain-containing protein.	0.900
A0A1L8FXP7	Casp7.S	A0A1L8FXP7	A0A1L8FDQ2	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.422
A0A1L8FXP7	Casp9.S	A0A1L8FXP7	A0A1L8FHM1	BH4_2 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.644
A0A1L8FXP7	Diablo.L	A0A1L8FXP7	A0A1L8I1L4	BH4_2 domain-containing protein.	Uncharacterized protein.	0.492