(20 nodes) Negative regulation of ubiquitin-protein transferase activity network (Xenopus laevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	mad2l1	Mad2l1 protein. (203 aa)
	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	bag5	Uncharacterized protein. (452 aa)
	bag5-2	Uncharacterized protein. (453 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	Bub1b.L	Uncharacterized protein. (890 aa)
	A0A1L8FBI0	RING-type domain-containing protein. (218 aa)
	bub3	Uncharacterized protein. (330 aa)
	Mad2l2.S	HORMA domain-containing protein. (233 aa)
	bub3-2	Uncharacterized protein. (330 aa)
	A0A1L8EV76	RING-type domain-containing protein. (695 aa)
	fbxo5	F-box domain-containing protein. (392 aa)
	bag2	BAG domain-containing protein. (213 aa)
	fbxo5-2	F-box domain-containing protein. (384 aa)
	bag2-2	BAG domain-containing protein. (179 aa)
	usp44	Ubiquitin carboxyl-terminal hydrolase. (704 aa)
	Usp44.L	Ubiquitin carboxyl-terminal hydrolase. (704 aa)
	smad7	Mothers against decapentaplegic homolog. (382 aa)
	Mad2l1.L	HORMA domain-containing protein. (203 aa)
	smad7-2	Mothers against decapentaplegic homolog. (382 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EZY9	psen1	A0A1L8EZY9	A0A1L8FAH5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.900
Bub1b.L	Mad2l1.L	A0A1L8FAZ4	A0A1L8HUW7	Uncharacterized protein.	HORMA domain-containing protein.	0.999
Bub1b.L	Mad2l2.S	A0A1L8FAZ4	A0A1L8FFM5	Uncharacterized protein.	HORMA domain-containing protein.	0.880
Bub1b.L	bub3	A0A1L8FAZ4	A0A1L8FEC6	Uncharacterized protein.	Uncharacterized protein.	0.999
Bub1b.L	bub3-2	A0A1L8FAZ4	A0A1L8FJ17	Uncharacterized protein.	Uncharacterized protein.	0.999
Bub1b.L	fbxo5	A0A1L8FAZ4	A0A1L8G212	Uncharacterized protein.	F-box domain-containing protein.	0.578
Bub1b.L	mad2l1	A0A1L8FAZ4	P79935	Uncharacterized protein.	Mad2l1 protein.	0.999
Mad2l1.L	Bub1b.L	A0A1L8HUW7	A0A1L8FAZ4	HORMA domain-containing protein.	Uncharacterized protein.	0.999
Mad2l1.L	Mad2l2.S	A0A1L8HUW7	A0A1L8FFM5	HORMA domain-containing protein.	HORMA domain-containing protein.	0.963
Mad2l1.L	bub3	A0A1L8HUW7	A0A1L8FEC6	HORMA domain-containing protein.	Uncharacterized protein.	0.998
Mad2l1.L	bub3-2	A0A1L8HUW7	A0A1L8FJ17	HORMA domain-containing protein.	Uncharacterized protein.	0.998
Mad2l1.L	fbxo5	A0A1L8HUW7	A0A1L8G212	HORMA domain-containing protein.	F-box domain-containing protein.	0.687
Mad2l1.L	mad2l1	A0A1L8HUW7	P79935	HORMA domain-containing protein.	Mad2l1 protein.	0.900
Mad2l2.S	Bub1b.L	A0A1L8FFM5	A0A1L8FAZ4	HORMA domain-containing protein.	Uncharacterized protein.	0.880
Mad2l2.S	Mad2l1.L	A0A1L8FFM5	A0A1L8HUW7	HORMA domain-containing protein.	HORMA domain-containing protein.	0.963
Mad2l2.S	bub3	A0A1L8FFM5	A0A1L8FEC6	HORMA domain-containing protein.	Uncharacterized protein.	0.899
Mad2l2.S	bub3-2	A0A1L8FFM5	A0A1L8FJ17	HORMA domain-containing protein.	Uncharacterized protein.	0.899
Mad2l2.S	mad2l1	A0A1L8FFM5	P79935	HORMA domain-containing protein.	Mad2l1 protein.	0.966
bag2	bag2-2	A0A1L8G3E4	A0A1L8G9D9	BAG domain-containing protein.	BAG domain-containing protein.	0.901
bag2	bag5	A0A1L8G3E4	A0A1L8F010	BAG domain-containing protein.	Uncharacterized protein.	0.792