(33 nodes) Misfolded protein binding network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8HGH4	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (183 aa)
	dnajb9	J domain-containing protein. (221 aa)
	A0A1L8HQD9	Uncharacterized protein. (218 aa)
	dnajb11-2	MGC81924 protein. (360 aa)
	dnajb9-2	Dnajb9-prov protein. (221 aa)
	clu	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (447 aa)
	hspa9	MGC52616 protein; Belongs to the heat shock protein 70 family. (670 aa)
	dnajc3	Cg8286-prov protein. (502 aa)
	hspa1l	Hsc70 protein; Belongs to the heat shock protein 70 family. (650 aa)
	hspa5-2	Hspa5 protein; Belongs to the heat shock protein 70 family. (655 aa)
	Hspa8.L	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	Hspa2.L	Uncharacterized protein; Belongs to the heat shock protein 70 family. (634 aa)
	bag6	Ubiquitin-like domain-containing protein. (1137 aa)
	hspa5	Uncharacterized protein; Belongs to the heat shock protein 70 family. (658 aa)
	Edem1.L	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (620 aa)
	ankrd45-2	ANK_REP_REGION domain-containing protein. (225 aa)
	A0A1L8GHI1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (582 aa)
	ankrd45	ANK_REP_REGION domain-containing protein. (227 aa)
	A0A1L8FZX6	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)
	Hspa9.L	Uncharacterized protein; Belongs to the heat shock protein 70 family. (665 aa)
	Clul1.L	Clusterin; Belongs to the clusterin family. (392 aa)
	A0A1L8FTT2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
	A0A1L8H3W0	Uncharacterized protein. (495 aa)
	sdf2	Uncharacterized protein. (220 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (122 aa)
	hspa13	Uncharacterized protein. (478 aa)
	Dnajc10.S	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (796 aa)
	dnajc10	Uncharacterized protein. (797 aa)
	Bag6.S	Ubiquitin-like domain-containing protein. (1116 aa)
	A0A310U4V1	Uncharacterized protein. (204 aa)
	dnajb11	LOC100036945 protein. (358 aa)
	sdf2l1	LOC496057 protein. (218 aa)
	sdf2-2	LOC494694 protein. (218 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FTT2	A0A1L8GHI1	A0A1L8FTT2	A0A1L8GHI1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.444
A0A1L8FTT2	A0A1L8HGH4	A0A1L8FTT2	A0A1L8HGH4	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.971
A0A1L8FTT2	Edem1.L	A0A1L8FTT2	A0A1L8GPH2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.548
A0A1L8FTT2	Hspa8.L	A0A1L8FTT2	A0A1L8FKY3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.515
A0A1L8FTT2	ankrd45	A0A1L8FTT2	A0A1L8GGB3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ANK_REP_REGION domain-containing protein.	0.654
A0A1L8FTT2	ankrd45-2	A0A1L8FTT2	A0A1L8GN10	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ANK_REP_REGION domain-containing protein.	0.654
A0A1L8FTT2	derl2	A0A1L8FTT2	A0A1L8H8B3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.902
A0A1L8FTT2	dnajc3	A0A1L8FTT2	Q7ZY02	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Cg8286-prov protein.	0.483
A0A1L8FTT2	hspa1l	A0A1L8FTT2	Q8AVE2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Hsc70 protein; Belongs to the heat shock protein 70 family.	0.463
A0A1L8FTT2	hspa5	A0A1L8FTT2	A0A1L8F6I3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.927
A0A1L8FTT2	hspa5-2	A0A1L8FTT2	Q8AVE3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Hspa5 protein; Belongs to the heat shock protein 70 family.	0.942
A0A1L8FZX6	A0A1L8GHI1	A0A1L8FZX6	A0A1L8GHI1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.444
A0A1L8FZX6	A0A1L8HGH4	A0A1L8FZX6	A0A1L8HGH4	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.974
A0A1L8FZX6	Edem1.L	A0A1L8FZX6	A0A1L8GPH2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.548
A0A1L8FZX6	Hspa8.L	A0A1L8FZX6	A0A1L8FKY3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.515
A0A1L8FZX6	ankrd45	A0A1L8FZX6	A0A1L8GGB3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ANK_REP_REGION domain-containing protein.	0.654
A0A1L8FZX6	ankrd45-2	A0A1L8FZX6	A0A1L8GN10	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ANK_REP_REGION domain-containing protein.	0.654
A0A1L8FZX6	dnajc3	A0A1L8FZX6	Q7ZY02	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Cg8286-prov protein.	0.410
A0A1L8FZX6	hspa1l	A0A1L8FZX6	Q8AVE2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Hsc70 protein; Belongs to the heat shock protein 70 family.	0.463
A0A1L8FZX6	hspa5	A0A1L8FZX6	A0A1L8F6I3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.927