139 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8FKX2	Uncharacterized protein. (305 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (607 aa)
	Q6DJF2_XENLA	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	dnajb11-2	MGC81924 protein. (360 aa)
	syt4-2	MGC84370 protein. (424 aa)
	sema5b	MGC68835 protein. (1088 aa)
	ifrd1-2	MGC69123 protein. (425 aa)
	ctnnb1-2	Ctnnb1-prov protein. (781 aa)
	dlx2-2	MGC80142 protein. (279 aa)
	ifrd2-2	Ifrd2 protein. (434 aa)
	appl2	MGC84621 protein. (662 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	sema6d	Semaphorin 6D4; Belongs to the semaphorin family. (1085 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	nog	Noggin; Belongs to the noggin family. (222 aa)
	nkx6-1	NK6 transcription factor related locus 1. (351 aa)
	dnajb11	LOC100036945 protein. (358 aa)
	A0A310U820	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	A0A310U4L0	Uncharacterized protein. (112 aa)
	sema6a-2	Sema domain-containing protein; Belongs to the semaphorin family. (1018 aa)
	ulk1	Protein kinase domain-containing protein. (1049 aa)
	rnf10-2	RING-type domain-containing protein. (757 aa)
	Rtn4r.L	Uncharacterized protein. (494 aa)
	Nf2.L	FERM domain-containing protein. (583 aa)
	nfatc4-2	RHD domain-containing protein. (1081 aa)
	A0A1L8HYI9	Uncharacterized protein; Belongs to the semaphorin family. (855 aa)
	Hook3.L	Calponin-homology (CH) domain-containing protein. (718 aa)
	A0A1L8HW98	Sema domain-containing protein; Belongs to the semaphorin family. (917 aa)
	Rest.L	Uncharacterized protein. (1421 aa)
	rufy3	Uncharacterized protein. (732 aa)
	Rapgef2.L	Uncharacterized protein. (1647 aa)
	Pcm1.L	PCM1_C domain-containing protein. (2031 aa)
	syt4	Uncharacterized protein. (424 aa)
	sema6a	Sema domain-containing protein; Belongs to the semaphorin family. (1018 aa)
	Ulk1.S	Protein kinase domain-containing protein. (967 aa)
	rnf10	RING-type domain-containing protein. (756 aa)
	Rtn4r.S	Uncharacterized protein. (494 aa)
	Nf2.S	FERM domain-containing protein. (584 aa)
	nfatc4	RHD domain-containing protein. (1086 aa)
	A0A1L8HPH6	Uncharacterized protein; Belongs to the semaphorin family. (853 aa)
	A0A1L8HMZ5	Sema domain-containing protein; Belongs to the semaphorin family. (917 aa)
	Rest.S	Uncharacterized protein. (1337 aa)
	A0A1L8HMD0	Uncharacterized protein. (720 aa)
	A0A1L8HLK0	Uncharacterized protein. (1639 aa)
	spart	MIT domain-containing protein. (595 aa)
	A0A1L8HI96	DMAP-interaction domain-containing protein. (1579 aa)
	nf1	Uncharacterized protein. (2759 aa)
	A0A1L8HG68	FERM domain-containing protein. (638 aa)
	ulk2	Protein kinase domain-containing protein. (1073 aa)
	A0A1L8HA48	DMAP-interaction domain-containing protein. (1538 aa)
	rb1	Uncharacterized protein. (899 aa)
	Nf1.S	Uncharacterized protein. (2774 aa)
	A0A1L8H818	Protein kinase domain-containing protein. (1055 aa)
	A0A1L8H6C5	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (418 aa)
	A0A1L8H508	Uncharacterized protein. (135 aa)
	A0A1L8H4Q1	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (200 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	sema4c-2	Uncharacterized protein; Belongs to the semaphorin family. (834 aa)
	sema4b	Uncharacterized protein; Belongs to the semaphorin family. (835 aa)
	prtg-2	Uncharacterized protein. (1151 aa)
	lingo1-2	Ig-like domain-containing protein. (606 aa)
	Pax10b	Paired box 10b. (281 aa)
	A0A1L8GE00	Uncharacterized protein. (1294 aa)
	A0A1L8GG21	Uncharacterized protein. (1334 aa)
	kifap3	Uncharacterized protein. (793 aa)
	ifrd2	Uncharacterized protein. (435 aa)
	sema3b	Uncharacterized protein; Belongs to the semaphorin family. (773 aa)
	sema3f	Uncharacterized protein; Belongs to the semaphorin family. (780 aa)
	A0A1L8GI68	Uncharacterized protein. (337 aa)
	A0A1L8GI80	Uncharacterized protein. (1175 aa)
	F2.L	Uncharacterized protein; Belongs to the peptidase S1 family. (564 aa)
	pax6-2	Uncharacterized protein. (467 aa)
	A0A1L8GML0	Uncharacterized protein. (1260 aa)
	Kifap3.L	Uncharacterized protein. (794 aa)
	sema3f-2	Uncharacterized protein; Belongs to the semaphorin family. (780 aa)
	sema3b-2	Uncharacterized protein; Belongs to the semaphorin family. (773 aa)
	A0A1L8GQJ5	Uncharacterized protein. (161 aa)
	sema4c	Uncharacterized protein; Belongs to the semaphorin family. (833 aa)
	Sema4b.S	Sema domain-containing protein; Belongs to the semaphorin family. (835 aa)
	Sema6d.S	Sema domain-containing protein; Belongs to the semaphorin family. (1047 aa)
	prtg	Uncharacterized protein. (1155 aa)
	lingo1	Ig-like domain-containing protein. (606 aa)
	sema3a	Uncharacterized protein; Belongs to the semaphorin family. (771 aa)
	kiaa1324l	Uncharacterized protein. (996 aa)
	Sema3c.S	Uncharacterized protein; Belongs to the semaphorin family. (748 aa)
	sema3d	Uncharacterized protein; Belongs to the semaphorin family. (766 aa)
	sema3e	Sema domain-containing protein; Belongs to the semaphorin family. (769 aa)
	ifrd1	Uncharacterized protein. (426 aa)
	sema3e-2	Sema domain-containing protein; Belongs to the semaphorin family. (276 aa)
	sema3c	Uncharacterized protein; Belongs to the semaphorin family. (748 aa)
	Kiaa1324l.L	Uncharacterized protein. (995 aa)
	sema3d-2	Uncharacterized protein; Belongs to the semaphorin family. (776 aa)
	sema3a-2	Uncharacterized protein; Belongs to the semaphorin family. (774 aa)
	A0A1L8GZY9	Sema domain-containing protein; Belongs to the semaphorin family. (574 aa)
	A0A1L8EKN4	Uncharacterized protein. (522 aa)
	A0A1L8EKZ0	Uncharacterized protein. (226 aa)
	A0A1L8EL97	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (315 aa)
	A0A1L8EP74	Homeobox domain-containing protein. (251 aa)
	Map2.S	Microtubule-associated protein. (1811 aa)
	Nr1d1.L	Uncharacterized protein. (671 aa)
	tmem98	Uncharacterized protein. (226 aa)
	A0A1L8ESG7	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	A0A1L8EVC1	Sema domain-containing protein. (1089 aa)
	dlx2	Homeobox domain-containing protein. (285 aa)
	A0A1L8EWE8	Homeobox domain-containing protein. (251 aa)
	Map2.L	Microtubule-associated protein. (1769 aa)
	A0A1L8EZY9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	A0A1L8F1K1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	brinp1	MACPF domain-containing protein. (757 aa)
	sema6c	Sema domain-containing protein; Belongs to the semaphorin family. (1042 aa)
	sema4a	Sema domain-containing protein; Belongs to the semaphorin family. (742 aa)
	psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (433 aa)
	sema6c-2	Sema domain-containing protein; Belongs to the semaphorin family. (995 aa)
	Sema4a.L	Sema domain-containing protein; Belongs to the semaphorin family. (719 aa)
	nkx6-2	Homeobox domain-containing protein. (281 aa)
	Sema4g.S	Uncharacterized protein; Belongs to the semaphorin family. (797 aa)
	Slit1.S	Uncharacterized protein. (1529 aa)
	A0A1L8FFM1	Uncharacterized protein. (588 aa)
	ski	c-SKI_SMAD_bind domain-containing protein. (717 aa)
	Pax10a	Homeobox domain-containing protein. (281 aa)
	Sirt2.S	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (402 aa)
	A0A1L8FHW0	Uncharacterized protein. (480 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	A0A1L8FJ20	Homeobox domain-containing protein. (259 aa)
	sema4g	Uncharacterized protein; Belongs to the semaphorin family. (831 aa)
	A0A1L8FJF5	Uncharacterized protein. (1320 aa)
	pax6	Uncharacterized protein. (467 aa)
	ryk	Uncharacterized protein. (596 aa)
	nr2e1	Uncharacterized protein. (386 aa)
	dynlt1	Uncharacterized protein. (113 aa)
	A0A1L8G548	Uncharacterized protein. (465 aa)
	Nr2e1.S	Uncharacterized protein. (386 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	A0A1L8FQD6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
	Mag.L	Uncharacterized protein. (625 aa)
	ski-2	c-SKI_SMAD_bind domain-containing protein. (717 aa)
	thy1	Ig-like domain-containing protein. (165 aa)
	sorl1	Uncharacterized protein. (2199 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EL97	A0A1L8G548	A0A1L8EL97	A0A1L8G548	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.602
A0A1L8EL97	Q6DJF2_XENLA	A0A1L8EL97	Q6DJF2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.439
A0A1L8EL97	ctnnb1	A0A1L8EL97	Q63ZT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Beta-catenin protein.	0.471
A0A1L8EL97	ctnnb1-2	A0A1L8EL97	Q7ZX35	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Ctnnb1-prov protein.	0.471
A0A1L8EL97	ryk	A0A1L8EL97	A0A1L8GB75	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.602
A0A1L8EL97	wnt7b	A0A1L8EL97	O42258	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.439
A0A1L8EP74	dlx2	A0A1L8EP74	A0A1L8EW85	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.666
A0A1L8EP74	dlx2-2	A0A1L8EP74	Q6DD47	Homeobox domain-containing protein.	MGC80142 protein.	0.666
A0A1L8ESG7	A0A1L8G548	A0A1L8ESG7	A0A1L8G548	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.602
A0A1L8ESG7	Q6DJF2_XENLA	A0A1L8ESG7	Q6DJF2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.438
A0A1L8ESG7	ctnnb1	A0A1L8ESG7	Q63ZT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Beta-catenin protein.	0.471
A0A1L8ESG7	ctnnb1-2	A0A1L8ESG7	Q7ZX35	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Ctnnb1-prov protein.	0.471
A0A1L8ESG7	ryk	A0A1L8ESG7	A0A1L8GB75	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.602
A0A1L8ESG7	wnt7b	A0A1L8ESG7	O42258	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.438
A0A1L8EWE8	dlx2	A0A1L8EWE8	A0A1L8EW85	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.666
A0A1L8EWE8	dlx2-2	A0A1L8EWE8	Q6DD47	Homeobox domain-containing protein.	MGC80142 protein.	0.666
A0A1L8EZY9	Map2.L	A0A1L8EZY9	A0A1L8EWQ3	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Microtubule-associated protein.	0.400
A0A1L8EZY9	ctnnb1	A0A1L8EZY9	Q63ZT4	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Beta-catenin protein.	0.986
A0A1L8EZY9	ctnnb1-2	A0A1L8EZY9	Q7ZX35	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Ctnnb1-prov protein.	0.977
A0A1L8EZY9	psen1	A0A1L8EZY9	A0A1L8FAH5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.900